1921
Volume 86, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

This study reviewed all patients diagnosed with imported cutaneous leishmaniasis (CL) at the Hospital for Tropical Diseases in London, United Kingdom, over an 11-year period. Diagnostic and epidemiologic information was collected prospectively for all patients with imported CL to this hospital during 1998–2009. A total of 223 patients were given a diagnosis of CL. Ninety patients were diagnosed with Old World CL, which was caused most commonly by complex (n = 20). A total of 71% were tourists to the Mediterranean region, 36% were migrants or visiting friends and relatives, and 17% were soldiers. One hundred thirty-three patients were given a diagnosis of New World CL. The subgenus caused 97 of these cases; 44% of these were in backpackers and 29% were in soldiers. Polymerase chain reaction was more sensitive and faster for detecting DNA (86% for Old World CL and 96% for New World CL) than culture. This is the largest study of imported leishmaniasis, and demonstrates that tourists to the Mediterranean and backpackers in Central and South America are at risk for this disease.

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2017-11-23
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References

  1. Desjeux P, , 2004. Leishmaniasis. Nat Rev Microbiol 2: 692.[Crossref]
  2. Bailey M, Lockwood DN, , 2007. Cutaneous leishmaniasis. Clin Dermatol 25: 203211.[Crossref]
  3. Campino L, Pratlong F, Abranches P, Rioux JA, Santos-Gomes G, Alves-Pires C, Cortes S, Ramada J, Cristovão JM, Afonso MO, Dedet JP, , 2006. Leishmaniasis in Portugal: enzyme polymorphism of Leishmania infantum based on the identification of 213 strains. Trop Med Int Health 11: 17081714.[Crossref]
  4. Antoniou M, Haralambous C, Mazeris A, Pratlong F, Dedet JP, Soteriadou K, , 2009. Leishmania donovani leishmaniasis in Cyprus. Lancet Infect Dis 9: 7677.[Crossref]
  5. Akkafa F, Dilmec F, Alpua Z, , 2008. Identification of Leishmania parasites in clinical samples obtained from cutaneous leishmaniasis patients using PCR-RFLP technique in endemic region, Sanliurfa Province, in Turkey. Parasitol Res 103: 583586.[Crossref]
  6. Al-Hucheimi SN, Sultan BA, Al-Dhalimi MA, , 2009. A comparative study of the diagnosis of Old World cutaneous leishmaniasis in Iraq by polymerase chain reaction and microbiologic and histopathologic methods. Int J Dermatol 48: 404408.[Crossref]
  7. Bhutto AM, Soomro FR, Baloch JH, Matsumoto J, Uezato H, Hashiguchi Y, Katakura K, , 2009. Cutaneous leishmaniasis caused by Leishmania (L.) major infection in Sindh province, Pakistan. Acta Trop 111: 295298.[Crossref]
  8. Katakura K, , 2009. Molecular epidemiology of leishmaniasis in Asia (focus on cutaneous infections). Curr Opin Infect Dis 22: 126130.[Crossref]
  9. Gadisa E, Genetu A, Kuru T, Jirata D, Dagne K, Aseffa A, Gedamu L, , 2007. Leishmania (Kinetoplastida): species typing with isoenzyme and PCR-RFLP from cutaneous leishmaniasis patients in Ethiopia. Exp Parasitol 115: 339343.[Crossref]
  10. Rhajaoui M, Nasereddin A, Fellah H, Azmi K, Amarir F, Al-Jawabreh A, Ereqat S, Planer J, Abdeen Z, , 2007. New clinico-epidemiologic profile of cutaneous leishmaniasis, Morocco. Emerg Infect Dis 13: 13581360.[Crossref]
  11. Benmously-Mlika R, Fenniche S, Kerkeni N, Aoun K, Khedim A, Mokhtar I, , 2008. Primary Leishmania infantum MON-80 endonasal leishmaniasis in Tunisia [in French]. Ann Dermatol Venereol 135: 389392.[Crossref]
  12. Gontijo B, de Carvalho ML, , 2003. American cutaneous leishmaniasis [in Portuguese]. Rev Soc Bras Med Trop 36: 7180.[Crossref]
  13. Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S, , 2007. Cutaneous leishmaniasis. Lancet Infect Dis 7: 581596.[Crossref]
  14. Reithinger R, Dujardin JC, , 2007. Molecular diagnosis of leishmaniasis: current status and future applications. J Clin Microbiol 45: 2125.[Crossref]
  15. Noyes HA, Reyburn H, Bailey JW, Smith D, , 1998. A nested-PCR-based schizodeme method for identifying Leishmania kinetoplast minicircle classes directly from clinical samples and its application to the study of the epidemiology of Leishmania tropica in Pakistan. J Clin Microbiol 36: 28772881.
  16. de Bruijn MH, Barker DC, , 1992. Diagnosis of New World leishmaniasis: specific detection of species of the Leishmania braziliensis complex by amplification of kinetoplast DNA. Acta Trop 52: 4558.[Crossref]
  17. Scarisbrick JJ, Chiodini PL, Watson J, Moody A, Armstrong M, Lockwood D, Bryceson A, Vega-López F, , 2006. Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis. Travel Med Infect Dis 4: 1421.[Crossref]
  18. Faber WR, Becht M, van Ginkel CJ, van der Kaay HJ, Vermeer BJ, Kager PA, , 1991. Cutaneous leishmaniasis in 49 patients in The Netherlands [in Dutch]. Ned Tijdschr Geneeskd 135: 229233.
  19. Zeegelaar JE, Steketee WH, van Thiel PP, Wetsteyn JC, Kager PA, Faber WR, , 2005. Changing pattern of imported cutaneous leishmaniasis in the Netherlands. Clin Exp Dermatol 30: 15.[Crossref]
  20. Lawn SD, Whetham J, Chiodini PL, Kanagalingam J, Watson J, Behrens RH, Lockwood DN, , 2004. New world mucosal and cutaneous leishmaniasis: an emerging health problem among British travellers. QJM 97: 781788.[Crossref]
  21. Faber WR, Oskam L, van Gool T, Kroon NC, Knegt-Junk KJ, Hofwegen H, van der Wal AC, Kager PA, , 2003. Value of diagnostic techniques for cutaneous leishmaniasis. J Am Acad Dermatol 49: 7074.[Crossref]
  22. Seaton RA, Morrison J, Man I, Watson J, Nathwani D, , 1999. Out-patient parenteral antimicrobial therapy: a viable option for the management of cutaneous leishmaniasis. QJM 92: 659667.[Crossref]
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  • Received : 07 Oct 2010
  • Accepted : 17 Aug 2011

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