Volume 86, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue fever is endemic to Trinidad and Tobago. A retrospective analysis of all adult admissions at a tertiary hospital in Trinidad treated for dengue during January 1–December 31, 2008 was performed. A total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show evidence of plasma leakage (12 of these cases did not show evidence of hemorrhage). There was a strong association between the lowest platelet value and hemoconcentration (χ = 13.16, < 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.


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  1. Guzman MG, Kouri G, , 2002. Dngue: an update. Lancet Infect Dis 2: : 3342.[Crossref] [Google Scholar]
  2. World Health Organization. Impact of Dengue. Available at: http://www.who.int/csr/disease/dengue/impact/en/index.html. Accessed November 19, 2009. [Google Scholar]
  3. Innis BL, Porterfield JS, , 1995. Dengue and dengue hemorrhagic fever. , ed. Kass Handbook of Infectious Diseases: Exotic Virus Infections. London: Chapman and Hall Medical, 103146. [Google Scholar]
  4. Harrington LC, Edman JD, Scott TW, , 2001. Who do female Aedes aegypti (Diptera: Culicidae) feed preferentially and frequently on human blood? J Med Entomol 38: : 411422.[Crossref] [Google Scholar]
  5. Teo D, Ng LC, Lam S, , 2009. Is dengue a threat to the blood supply? Transfus Med 19: 6677.[Crossref] [Google Scholar]
  6. Chadee DD, Martinez R, , 2000. Landing periodicity of Aedes aegypti with implications for dengue transmission in Trinidad, West Indies. J Vector Ecol 25: 158163. [Google Scholar]
  7. Halstead SB, , 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239: 476481.[Crossref] [Google Scholar]
  8. Sullivan NJ, , 2001. Antibody mediated enhancement of viral disease. Curr Top Microbiol Immunol 260: 145169. [Google Scholar]
  9. Saito M, Oishi K, Inoue S, Dimaano EM, Alera MT, Robles AM, Estrella BD, Jr Kumatori A, Moji K, Alonzo MT, Buerano CC, Matias RR, Morita K, Natividad FF, Nagatake T, , 2004. Association of increased platelet associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. Clin Exp Immunol 138: 299303.[Crossref] [Google Scholar]
  10. Avirutnan P, Zhang L, Punyadee N, Manuyakorn A, Puttikhunt C, Kasinrerk W, Malasit P, Atkinson JP, Diamond MS, , 2007. Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E. PLoS Pathog 3: e183.[Crossref] [Google Scholar]
  11. Teelucksingh S, Mangray AS, Barrow S, Jankey N, , 1997. Dengue hemorrhagic fever/dengue shock syndrome. An unwelcome arrival in Trinidad. West Indian Med J 46: 3842. [Google Scholar]
  12. Chadee DD, Shivnauth B, Rawlins SC, Chen AA, , 2007. Climate, mosquito indices and the epidemiology of dengue fever in Trinidad. Ann Trop Med Parasitol 101: 6977.[Crossref] [Google Scholar]
  13. Pan American Health Organization. Cases of Dengue in the Americas, 2007. Available at: http://www.paho.org/English/AD/DPC/CD/dengue-cases-2007.htm#c. Accessed April 2, 2010. [Google Scholar]
  14. Pan American Health Organization. Regional Update on Dengue. March 17, 2009. Available at: http://new.paho.org/. Accessed November 19, 2009. [Google Scholar]
  15. Ahluwalia G, Sharma SK, , 2004. Dengue: current trends and challenges—an Indian perspective. JAPI 52: 561563. [Google Scholar]
  16. Chairulfatah A, Setiabudi D, Agoes R, Colebunders R, , 2003. Thrombocytopenia and platelet transfusions in dengue hemorrhagic fever and dengue shock syndrome. Dengue Bull 27: 138143. [Google Scholar]
  17. Lye DC, Vernon JL, Sun Y, Sin Leo Y, , 2009. Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection. Clin Infect Dis 48: 12621265.[Crossref] [Google Scholar]
  18. Watts DM, Burke DS, Harrison BA, Whitmire RE, Nisalak A, , 1987. Effect of temperature on the vector efficiency of Aedes aegypti for dengue 2 virus. Am J Trop Med Hyg 36: 143152. [Google Scholar]
  19. Koopman JS, Prevots DR, Vaca Marin MA, Gomex Dantes H, Zarate Aquino ML, Longini IM, Jr Sepulveda Amor L, , 1991. Determinants and predictors of dengue infection in Mexico. Am J Epidemiol 133: 11681178.[Crossref] [Google Scholar]
  20. Hunsperger EA, Yoksan S, Buchy P, Nguyen VC, Sekaran SD, Enria DA, Pelegrino JL, Vázquez S, Artsob H, Drebot M, Gubler DJ, Halstead SB, Guzmán MG, Margolis HS, Nathanson CM, Rizzo Lic NR, Bessoff KE, Kliks S, Peeling RW, , 2009. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerg Infect Dis 15: 436440.[Crossref] [Google Scholar]
  21. World Health Organization. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. 2009. Available at: http://whqlibdoc.who.int/publications/2009/9789241547871_eng.pdf. Accessed August 12, 2010. [Google Scholar]
  22. Wichmann O, Gascon J, Schunk M, Puente S, Siikamaki H, Gjørup I, Lopez-Velez R, Clerinx J, Peyerl-Hoffmann G, Sundøy A, Genton B, Kern P, Calleri G, de Górgolas M, Mühlberger N, Jelinek T, ; European Network on Surveillance of Imported Infectious Diseases, 2007. Severe dengue virus infection in travelers: risk factors and laboratory indicators. J Infect Dis 195: 10891096.[Crossref] [Google Scholar]
  23. Vaugh DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Endy TP, Raengsakulrach B, Rothman AL, Ennis FA, Nisalak A, , 2000. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis 181: 29.[Crossref] [Google Scholar]
  24. Avirutnan P, Malasit P, Seliger B, Bhakdi S, Husmann M, , 1998. Dengue virus infection of human endothelial cells leads to chemokine production, complement activation and apoptosis. J Immunol 161: 63386346. [Google Scholar]
  25. Azeredo EL, Zagne SM, Santiago MA, Gouvea AS, Santana AA, Neves-Souza PC, Nogueira RM, Miagostovich MP, Kubelka CF, , 2001. Characterization of lymphocyte response and cytokine patterns with dengue fever. Imunobiology 204: 494507.[Crossref] [Google Scholar]
  26. Dzieczkowski JS, Anderson KC, Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, , 2001. Transfusion biology and therapy. , ed. Harrison’s Principles of Medicine, 15th edition. New York: McGraw-Hill, 733738. [Google Scholar]
  27. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisir E, , 1999. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 340: 409417.[Crossref] [Google Scholar]

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  • Received : 09 Apr 2010
  • Accepted : 27 Sep 2011
  • Published online : 01 Mar 2012

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