Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Because 8-aminoquinolines affect critical survival stages of parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use. Primaquine was approved more than 50 years ago after extensive clinical testing. Review of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism suggests that manipulation of these factors might dissociate 8-aminoquinoline efficacy from toxicity and lead to an improved therapeutic index.


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  • Received : 01 Aug 2011
  • Accepted : 13 Sep 2011
  • Published online : 01 Dec 2011

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