Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We describe a case of a woman who developed a peripheral polyneuropathy shortly after completing 4 weekly doses of mefloquine hydrochloride (250 mg) malaria prophylaxis. Although mefloquine-related central nervous system neuropathy is well described in the literature, peripheral polyneuropathy similar to this case has been documented only once before, to our knowledge.


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  1. Toovey S, , 2009. Mefloquine neurotoxicity: a literature review. Travel Med Infect Dis 7: 26.[Crossref]
  2. Jha S, Kumar R, Kumar R, , 2006. Mefloquine toxicity presenting with polyneuropathy: a report of two cases in India. Trans R Soc Trop Med Hyg 100: 594596.[Crossref]
  3. Watt-Smith S, Mehta K, Scully C, , 2001. Mefloquine-induced trigeminal sensory neuropathy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92: 163165.[Crossref]
  4. Olson PE, Kennedy CA, Morte PD, , 1992. Paresthesias and mefloquine prophylaxis. Ann Intern Med 117: 10581059.[Crossref]
  • Received : 27 Jun 2011
  • Accepted : 30 Aug 2011

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