1921
Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Influenza can be manifested as an acute febrile illness, with symptoms similar to many pathogens endemic to Cambodia. The objective of this study was to evaluate the Quickvue influenza A+B rapid test to identify the etiology of acute febrile illness in Cambodia. During December 2006–May 2008, patients enrolled in a study to identify the etiology of acute febrile illnesses were tested for influenza by real-time reverse transcriptase PCR (RT-PCR) and Quickvue influenza A+B rapid test. The prevalence of influenza was 19.7% by RT-PCR. Compared with RT-PCR, the sensitivity and specificity of the rapid test were 52.1% and 92.5%, respectively. The influenza rapid test identified the etiology in 10.2% of enrollees and ≥ 35% during peak times of influenza activity. This study suggests that rapid influenza tests may be useful during peak times of influenza activity in an area where several different etiologies can present as an acute febrile illness.

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/content/journals/10.4269/ajtmh.2011.11-0390
2011-12-01
2017-11-20
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References

  1. Simmerman JM, Chittaganpitch M, Erdman D, Sawatwong P, Uyeki TM, Dowell SF, , 2007. Field performance and new uses of rapid influenza testing in Thailand. Int J Infect Dis 11: 166171.[Crossref]
  2. Wunderli W, Thomas Y, Muller DA, Dick M, Kaiser L, , 2003. Rapid antigen testing for the surveillance of influenza epidemics. Clin Microbiol Infect 9: 295300.[Crossref]
  3. Rodriguez WJ, Schwartz RH, Thorne MM, , 2002. Evaluation of diagnostic tests for influenza in a pediatric practice. Pediatr Infect Dis J 21: 193196.[Crossref]
  4. Uyeki TM, , 2003. Influenza diagnosis and treatment in children: a review of studies on clinically useful tests and antiviral treatment for influenza. Pediatr Infect Dis J 22: 164177.
  5. Uyeki TM, Prasad R, Vukotich C, Stebbins S, Rinaldo CR, Ferng YH, Morse SS, Larson EL, Aiello AE, Davis B, Monto AS, , 2009. Low sensitivity of rapid diagnostic test for influenza. Clin Infect Dis 48: e89e92.[Crossref]
  6. Blair PJ, Wierzba TF, Touch S, Vonthanak S, Xu X, Garten RJ, Okomo-Adhiambo MA, Klimov AI, Kasper MR, Putnam SD, , 2010. Influenza epidemiology and characterization of influenza viruses in patients seeking treatment for acute fever in Cambodia. Epidemiol Infect 138: 199209.[Crossref]
  7. Agoritsas K, Mack K, Bonsu BK, Goodman D, Salamon D, Marcon MJ, , 2006. Evaluation of the Quidel QuickVue test for detection of influenza A and B viruses in the pediatric emergency medicine setting by use of three specimen collection methods. J Clin Microbiol 44: 26382641.[Crossref]
  8. Hurt AC, Alexander R, Hibbert J, Deed N, Barr IG, , 2007. Performance of six influenza rapid tests in detecting human influenza in clinical specimens. J Clin Virol 39: 132135.[Crossref]
  9. Mehlmann M, Bonner AB, Williams JV, Dankbar DM, Moore CL, Kuchta RD, Podsiad AB, Tamerius JD, Dawson ED, Rowlen KL, , 2007. Comparison of the MChip to viral culture, reverse transcription-PCR, and the QuickVue influenza A+B test for rapid diagnosis of influenza. J Clin Microbiol 45: 12341237.[Crossref]
  10. Bhavnani D, Phatinawin L, Chantra S, Olsen SJ, Simmerman JM, , 2007. The influence of rapid influenza diagnostic testing on antibiotic prescribing patterns in rural Thailand. Int J Infect Dis 11: 355359.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2011.11-0390
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  • Received : 20 Jun 2011
  • Accepted : 30 Aug 2011

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