1921
Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy of a doxycyline hyclate rodent bait to prophylactically protect and cure small-mammal reservoirs and reduce infection rates in questing ticks for and . The doxycycline-laden bait was formulated at a concentration of 500 mg/kg and delivered during the immature tick feeding season in rodent-targeted bait boxes. The percentage of infected small mammals recovered from treated areas after 2 years of treatment was reduced by 86.9% for and 74% for . Infection rates in questing nymphal ticks for both and were reduced by 94.3% and 92%, respectively. Results from this study indicate that doxycycline-impregnated bait is an effective means of reducing infection rates for and in both rodent reservoirs and questing ticks.

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2011-12-01
2017-12-14
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References

  1. Piesman J, Eisen L, , 2008. Prevention of tick-borne diseases. Annu Rev Entomol 53: 323343.[Crossref]
  2. Stafford KC III, Kitron U, Gray J, Kahl O, Lane RS, Stanek G, , 2002. Environmental management for Lyme borreliosis control. , eds. Lyme Borreliosis Biology, Epidemiology and Control. New York, NY: CABI Publishing, 301334.[Crossref]
  3. Hayes EB, Piesman J, , 2003. How can we prevent Lyme disease? N Engl J Med 348: 24242430.[Crossref]
  4. Hayes EB, Maupin GO, Mount GA, Piesman J, , 1999. Assessing the prevention effectiveness of local Lyme disease control. J Public Health Manag Pract 5: 8492.[Crossref]
  5. Schulze TL, Jordan RA, Krivenko AJ, , 2005. Effects of barrier application of granular deltamethrin on subadult Ixodes scapularis (Acari: Ixodidae) and nontarget forest floor arthropods. J Econ Entomol 98: 976981.[Crossref]
  6. Schulze TL, Jordan RA, Schulze CJ, Healy SP, , 2008. Suppression of Ixodes scapularis (Acari: Ixodidae) following annual habitat-targeted acaricide applications against fall populations of adults. J Am Mosq Control Assoc 24: 566570.[Crossref]
  7. Ginsberg HS, , 1994. Lyme disease and conservation. Conserv Biol 8: 343353.[Crossref]
  8. Schulze TL, Jordan RA, Hung RW, Krivenko AJ, Jr Schulze JJ, Jordan TM, , 2001. Effects of an application of granular carbaryl on non-target forest floor arthropods. J Econ Entomol 94: 123128.[Crossref]
  9. Piesman J, , 2006. Strategies for reducing the risk of Lyme borreliosis in North America. Int J Med Microbiol 296 (Suppl 40): 1722.[Crossref]
  10. Gould LH, Nelson RS, Griffith KS, Hayes EB, Piesman J, Mead PS, Cartter ML, , 2008. Knowledge, attitudes, and behaviors regarding Lyme disease prevention among Connecticut residents, 1999–2004. Vector Borne Zoonotic Dis 8: 769776.[Crossref]
  11. Dolan MC, Maupin GO, Schneider BS, Denatale C, Hamon H, Cole C, Zeidner NS, Stafford KC III, , 2004. Control of immature Ixodes scapularis (Acari: Ixodidae) on rodent reservoirs of Borrelia burgdorferi in a residential community of southeastern Connecticut. J Med Entomol 41: 10431054.[Crossref]
  12. Schulze TL, Jordan RA, Schulze CJ, Healy SP, Jahn MB, Piesman J, , 2007. Integrated use of 4-Poster passive topical treatment devices for deer, targeted acaricide applications, and Maxforce TMS bait boxes to rapidly suppress populations of Ixodes scapularis (Acari: Ixodidae) in a residential landscape. J Med Entomol 44: 830839.[Crossref]
  13. Fish D, Childs JE, , 2009. Community-based prevention of Lyme disease and other tick-borne diseases through topical application of acaricide to white-tailed deer: background and rationale. Vector Borne Zoonotic Dis 9: 357364.[Crossref]
  14. Dolan MC, Zeidner NS, Gabitzsch ES, Dietrich G, Borchert JN, Poche RM, Piesman J, , 2008. A doxycycline hyclate rodent bait formulation for prophylaxis and cure of tick-transmitted Borrelia burgdorferi . Am J Trop Med Hyg 78: 803805.
  15. Zeidner NS, Brandt KS, Dady E, Dolan MC, Happ C, Piesman J, , 2004. Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis. Antimicrob Agents Chemother 48: 26972699.[Crossref]
  16. Zeidner NS, Massung R, Dolan MC, Dadey E, Gabitzsch E, Dietrich G, Levin M, , 2008. A sustained release formulation of doxycycline hyclate (AtridoxTM) prevents simultaneous transmission of Anaplasma phagocytophilum and Borrelia burgdorferi transmitted by tick bite. J Med Microbiol 57: 463468.[Crossref]
  17. Schulze TL, Jordan RA, Hung RW, Taylor RC, Markowski D, Chomsky MS, , 2001. Efficacy of granular deltamethrin against Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs. J Med Entomol 38: 344346.[Crossref]
  18. Schulze TL, Jordan RA, Schulze CJ, , 2005. Host associations of Ixodes scapularis (Acari: Ixodidae) in residential and natural settings in a Lyme disease-endemic area in New Jersey. J Med Entomol 42: 966973.[Crossref]
  19. Schulze TL, Bowen GS, Lakat MF, Parkin WE, Shisler JK, , 1986. Seasonal abundance and host utilization of Ixodes dammini (Acari: Ixodidae) and other ixodid ticks from an endemic Lyme disease focus in New Jersey, USA. J Med Entomol 23: 105109.[Crossref]
  20. Sinsky RJ, Piesman J, , 1989. Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents. J Clin Microbiol 27: 17231727.
  21. Piesman J, Mather TN, Donahue JG, Levine J, Campbell JD, Karakashian SJ, Spielman A, , 1986. Comparative prevalence of Babesia microti and Borrelia burgdorferi in four populations of Ixodes dammini in eastern Massachusetts. Acta Trop 43: 263270.
  22. Ginsberg HS, Ewing CP, , 1989. Comparison of flagging, walking, trapping, and collecting ticks from hosts as sampling methods for northern deer ticks, Ixodes dammini, and lone star ticks, Amblyomma americanum (Acari: Ixodidae). Exp Appl Acarol 7: 313322.[Crossref]
  23. Schulze TL, Jordan RA, Hung RW, , 1997. Biases associated with several sampling methods used to estimate the abundance of Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae). J Med Entomol 34: 615623.[Crossref]
  24. Schulze TL, Jordan RA, Hung RW, , 2001. Effects of selected meteorological factors on diurnal questing of adult Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae). J Med Entomol 38: 318324.[Crossref]
  25. Schulze TL, Jordan RA, , 2003. Meteorologically mediated diurnal questing of Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs. J Med Entomol 40: 395402.[Crossref]
  26. Zeidner NS, Schneider BS, Dolan MC, Piesman J, , 2001. An analysis of spirochete load, strain, and pathology in a model of tick-transmitted Lyme borreliosis. Vector Borne Zoonotic Dis 1: 3544.[Crossref]
  27. Houck JA, Hojgaard A, Piesman J, Kuchta RD, , 2011. Low-density microarrays for the detection of Borrelia burgdorferi s.s. (the Lyme disease spirochete) in nymphal Ixodes scapularis . Ticks Tick Borne Dis 2: 2736.[Crossref]
  28. Zeinder NS, Burkot TR, Massung R, Nicholson WL, Dolan MC, Rutherford JS, Biggerstaff BJ, Maupin GO, , 2000. Transmission of the agent of HGE by Ixodes spinipalpis ticks: evidence of an enzootic cycle of co-infection with Borrelia burgdorferi in Northern Colorado. J Infect Dis 182: 616619.[Crossref]
  29. Massung RF, Slater KG, , 2003. Comparison of PCR assays for detection of the agent of human granulocytic ehrlichiosis, Anaplasma phagocytophilum . J Clin Microbiol 41: 717722.[Crossref]
  30. Johnson SE, Klein GC, Schmid GP, Feeley JC, , 1984. Susceptibility of the Lyme disease spirochete to seven antimicrobial agents. Yale J Biol Med 57: 549553.
  31. Mount GA, , 1981. Amblyomma americanum: area control of overwintered nymphs and adults in Oklahoma with acaricides. J Econ Entomol 74: 2426.[Crossref]
  32. Witmer G, Kogan M, Jepson P, , 2007. The ecology of vertebrate pests and integrated pest management (IPM). , eds. Perspectives in Ecological Theory and Integrated Pest Management. Cambridge, United Kingdom: Cambridge University Press, 393410.[Crossref]
  33. Borchert JN, Enscore RE, Eisen RJ, Atiku LA, Owor N, Acayo S, Babi N, Montenieri JA, Gage KL, , 2010. Evaluation of rodent bait containing imidacloprid for the control of fleas on commensal rodents in a plague-endemic region of northwest Uganda. J Med Entomol 47: 842850.[Crossref]
  34. Jones CG, Ostfeld RS, Richard MP, Schauber EM, Wolff JO, , 1998. Chain reactions linking acorns to gypsy moth outbreaks and Lyme disease risk. Science 13: 10231026.[Crossref]
  35. Ostfeld RS, Canham CD, Oggenfuss K, Winchcombe RJ, Keesing F, , 2006. Climate, deer, rodents, and acorns as determinants of variation in Lyme-disease risk. PLoS Biol 4: e182.[Crossref]
  36. Adelson ME, Rao R-VS, Tilton RC, Cabets K, Eskow E, Fein L, Occi JL, Mordechai E, , 2002. Prevalence of Borrelia burgdorferi, Bartonella spp., Babesia microti, and Anaplasma phagocytophilum in Ixodes scapularis ticks collected in northern New Jersey. J Clin Microbiol 42: 27992801.[Crossref]
  37. Stafford KC III, Massung RF, Mangarelli LA, Ijdo JW, Anderson JF, , 1999. Infection with agents of human granulocytic ehrlichiosis, Lyme disease, and babesiosis in wild white-footed mice in Connecticut. J Clin Microbiol 37: 28872892.
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  • Received : 06 May 2011
  • Accepted : 30 Aug 2011

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