Volume 85, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



is a significant cause of diarrheal disease in children in developing countries. The sporozoite antigen Muc4 is important for infection of host cells, and could be a candidate vaccine antigen. However, this antigen is polymorphic between and . We investigated antibody responses to Muc4 and Muc4 antigen in children in Bangladesh infected with . Antibody responses were compared between children with cryptosporidial diarrhea (cases) and uninfected children with diarrhea (controls). There was a significant IgM response to Muc4 from both species in cases compared with controls, which increased over time, and was higher in children with persistent diarrhea. Despite sequence polymorphisms, antibody responses to Muc4 and . Muc4 were significantly correlated. These results suggest that the human antibody response to Muc4 is cross-reactive between species, but in young children does not mature to an IgG response within the period observed in this study.


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  • Received : 28 Apr 2011
  • Accepted : 06 Jun 2011
  • Published online : 01 Sep 2011

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