1921
Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

and malaria are endemic to many parts of the world and humans can be co-infected with both species. Because each species has different biological and clinical characteristics, accurate differentiation of the infecting species is essential for effective treatment. Therefore, we produced three monoclonal antibodies that recognize the lactate dehydrogenase of , , or both to develop the first , , and mixed-species infections malaria antigen detection kit. The detection limits of this kit were 150 and 250 parasites/μL for and , respectively, and the kit was able to detect mixed-species infections. The sensitivity and specificity of this kit was assessed with 722 clinical specimens. Our results showed that its sensitivities for , , and mixed-species infection were 96.5%, 95.3%, and 85.7%, respectively. In addition, its specificity was high (99.4%).

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  • Received : 27 Apr 2011
  • Accepted : 12 Sep 2011

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