1921
Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Ferroquine (FQ), a chloroquine (CQ) analog, is being developed to treat persons with malaria. In 146 field isolates from western Kenya, we measured 50% inhibitory concentrations (IC; nM) of CQ and FQ by a SYBR Green I assay. Reference clones included W2 (CQ resistant) and D6 (CQ sensitive). Mutation analysis was done for CQ-resistance transporter gene ( K76T). Median IC values for FQ were lower than CQ for field isolates and the W2 clone (both < 0.05). The mutation (76T), which was detected in > 80% of isolates, conferred higher CQ IC values ( < 0.05) and modestly lower FQ IC values ( < 0.05), versus wild type (K76). FQ is more potent than CQ against CQ-resistant field isolates and the W2 clone, and is less affected by 76T. These findings support the notion that FQ could be useful in treating persons with malaria.

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2011-12-01
2017-11-22
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  • Received : 24 Apr 2011
  • Accepted : 12 Sep 2011

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