Volume 85, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The parasite frequently causes genital lesions in women and could increase the risk of human immunodeficiency virus (HIV) transmission. This study quantifies the HIV target cells in schistosome-infected female genital mucosa. Cervicovaginal biopsies with and without schistosomiasis were immunostained for quantification of CD4 T lymphocytes (CD3, CD8), macrophages (CD68), and dendritic Langerhans cells (S100 protein). We found significantly higher densities of genital mucosal CD4 T lymphocytes and macrophages surrounding schistosome ova compared with cervicovaginal mucosa without ova ( = 0.034 and = 0.018, respectively). We found no increased density of Langerhans cells ( = 0.25). This study indicates that may significantly increase the density of HIV target cells (CD4 T lymphocytes and macrophages) in the female genitals, creating a beneficial setting for HIV transmission. Further studies are needed to confirm these findings and to evaluate the effect of anti-schistosomal treatment on female genital schistosomiasis.


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  • Received : 07 Mar 2011
  • Accepted : 16 Jul 2011
  • Published online : 01 Dec 2011

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