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Volume 85, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

During May 4, 2007–February 29, 2008, the United States resettled 6,159 refugees from Tanzania. Refugees received pre-departure antimalarial treatment with sulfadoxine-pyrimethamine (SP), partially supervised (three/six doses) artemether-lumefantrine (AL), or fully supervised AL. Thirty-nine malaria cases were detected. Disease incidence was 15.5/1,000 in the SP group and 3.2/1,000 in the partially supervised AL group (relative change = –79%, 95% confidence interval = –56% to –90%). Incidence was 1.3/1,000 refugees in the fully supervised AL group (relative change = –92% compared with SP group; 95% confidence interval = –66% to –98%). Among 39 cases, 28 (72%) were in refugees < 15 years of age. Time between arrival and symptom onset (median = 14 days, range = 3–46 days) did not differ by group. Thirty-two (82%) persons were hospitalized, 4 (10%) had severe manifestations, and 9 (27%) had parasitemias > 5% (range = < 0.1–18%). Pre-departure presumptive treatment with an effective drug is associated with decreased disease among refugees.

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2011-10-01
2017-09-25
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References

  1. US Department of Homeland Security, 2009. 2009 Yearbook of Immigration Statistics. Available at: http://www.dhs.gov/files/statistics/publications/yearbook.shtm. Accessed March 1, 2011.
  2. Boggild AK, Parise ME, Lewis LS, Kain KC, , 2007. Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II). Am J Trop Med Hyg 76: 208223.
  3. Green MD, Nettey H, Villalva Rojas O, Pamanivong C, Khounsaknalath L, Grande Ortiz M, Newton PN, Fernandez FM, Vongsack L, Manolin O, , 2007. Use of refractometry and colorimetry as field methods to rapidly assess antimalarial drug quality. J Pharm Biomed Anal 43: 105110.[Crossref]
  4. Eriksen J, Mwankusye S, Mduma S, Veiga MI, Kitua A, Tomson G, Petzold MG, Swedberg G, Gustafsson LL, Warsame M, , 2008. Antimalarial resistance and DHFR/DHPS genotypes of Plasmodium falciparum three years after introduction of sulfadoxine-pyrimethamine and amodiaquine in rural Tanzania. Trans R Soc Trop Med Hyg 102: 137142.[Crossref]
  5. Mugittu K, Abdulla S, Falk N, Masanja H, Felger I, Mshinda H, Beck HP, Genton B, , 2005. Efficacy of sulfadoxine-pyrimethamine in Tanzania after two years as first-line drug for uncomplicated malaria: assessment protocol and implication for treatment policy strategies. Malar J 4: 55.[Crossref]
  6. World Health Organization, 2010. WHO List of Prequalified Medicinal Products. Available at: http://apps.who.int/prequal/. Accessed March 1, 2011.
  7. Makanga M, Premji Z, Falade C, Karbwang J, Mueller EA, Andriano K, Hunt P, De Palacios PI, , 2006. Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: a pooled analysis of individual patient data. Am J Trop Med Hyg 74: 991998.
  8. Piola P, Fogg C, Bajunirwe F, Biraro S, Grandesso F, Ruzagira E, Babigumira J, Kigozi I, Kiguli J, Kyomuhendo J, Ferradini L, Taylor W, Checchi F, Guthmann JP, , 2005. Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial. Lancet 365: 14671473.[Crossref]
  9. Novartis, 2004. Monograph: Coartem. Third edition. Available at: http://www.smi-voyage-sante.com/docs/KitsPaluComposants/Coartem_monographie.pdf. Accessed March 1, 2011.
  10. White NJ, van Vugt M, Ezzet F, , 1999. Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine. Clin Pharmacokinet 37: 105125.[Crossref]
  11. Ahmed R, Bowen J, O'Donnell W, , 2004. Cultural competence and language interpreter services in Minnesota: results of a needs assessment survey administered to physician members of the Minnesota Medical Association. Minn Med 87: 4042.
  12. Derose KP, Escarce JJ, Lurie N, , 2007. Immigrants and health care: sources of vulnerability. Health Aff (Millwood) 26: 12581268.[Crossref]
  13. Garrett CR, Treichel CJ, Ohmans P, , 1998. Barriers to health care for immigrants and nonimmigrants: a comparative study. Minn Med 81: 5255.
  14. Weiss R, , 2005. Improving care for immigrants. Health Prog 86: 1112.
  15. Newman RD, Parise ME, Barber AM, Steketee RW, , 2004. Malaria-related deaths among U.S. travelers, 1963–2001. Ann Intern Med 141: 547555.[Crossref]
  16. Collinet-Adler S, Stauffer WM, Boulware DR, Larsen KL, Rogers TB, Williams DN, , 2007. Financial implications of refugee malaria: the impact of pre-departure presumptive treatment with anti-malarial drugs. Am J Trop Med Hyg 77: 458463.
  17. Martens P, Hall L, , 2000. Malaria on the move: human population movement and malaria transmission. Emerg Infect Dis 6: 103109.[Crossref]
  18. Zucker JR, , 1996. Changing patterns of autochthonous malaria transmission in the United States: a review of recent outbreaks. Emerg Infect Dis 2: 3743.[Crossref]
  19. Darsie RF, Ward RA, , 2005. Identification and Geographical Distribution of the Mosquitoes of North America, North of Mexico. Gainesville, FL: University Press of Florida.
  20. Filler SJ, MacArthur JR, Parise M, Wirtz R, Eliades MJ, Dasilva A, Steketee R, , 2006. Locally acquired mosquito-transmitted malaria: a guide for investigations in the United States. MMWR Recomm Rep 55: 19.
  21. Maroushek SR, Aguilar EF, Stauffer W, Abd-Alla MD, , 2005. Malaria among refugee children at arrival in the United States. Pediatr Infect Dis J 24: 450452.[Crossref]
  22. Ndao M, Bandyayera E, Kokoskin E, Gyorkos TW, MacLean JD, Ward BJ, , 2004. Comparison of blood smear, antigen detection, and nested-PCR methods for screening refugees from regions where malaria is endemic after a malaria outbreak in Quebec, Canada. J Clin Microbiol 42: 26942700.[Crossref]
  23. Stauffer WM, Newberry AM, Cartwright CP, Rosenblatt JE, Hanson KL, Sloan L, Tsukayama DT, Taylor C, Juni BA, , 2006. Evaluation of malaria screening in newly arrived refugees to the United States by microscopy and rapid antigen capture enzyme assay. Pediatr Infect Dis J 25: 948950.[Crossref]
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  • Received : 05 Mar 2011
  • Accepted : 17 May 2011

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