1921
Volume 85, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

and cause common sexually transmitted infections in humans and cattle, respectively. Mouse models of trichomoniasis are important for pathogenic and therapeutic studies. Here, we compared murine genital infections with and . Persistent vaginal infection with was established with 100 parasites but infection required doses of 10, perhaps because of greater susceptibility to killing by mouse vaginal polymorphonuclear leukocytes. Infection with persisted longest after combined treatment of mice with estrogen and dexamethasone, whereas infection was only short-lived when mice were given estrogen or dexamethasone alone, co-infected with , and/or pretreated with antibiotics. Infection rates were similar with metronidazole-resistant (MR) and metronidazole-sensitive (MS) High dose but not low dose metronidazole treatment controlled infection with MS better than MR These murine models will be valuable for investigating the pathogenesis and treatment of trichomoniasis.

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  • Received : 02 Mar 2011
  • Accepted : 05 Jul 2011

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