1921
Volume 85, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The presence of circulating immune complexes (CICs) is a characteristic feature of human lymphatic filariasis. However, the role of CICs in modulating granulocyte function and complement functional activity in filarial infection is unknown. The levels of CICs in association with complement activation in clinically asymptomatic, filarial-infected patients (INF); filarial-infected patients with overt lymphatic pathologic changes (CPDT); and uninfected controls (EN) were examined. Significantly increased levels of CICs and enhanced functional efficiency of the classical and mannose-binding lectin pathways of the complement system was observed in INF compared with CPDT and EN. Polyethylene glycol–precipitated CICs from INF and CPDT induced significantly increased granulocyte activation compared with those from EN, determined by the increased production of neutrophil granular proteins and a variety of pro-inflammatory cytokines. Thus, CIC-mediated enhanced granulocyte activation and modulation of complement function are important features of filarial infection and disease.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2011.11-0086
2011-07-01
2017-11-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/85/1/089.html?itemId=/content/journals/10.4269/ajtmh.2011.11-0086&mimeType=html&fmt=ahah

References

  1. Nutman TB, Kumaraswami V, , 2001. Regulation of the immune response in lymphatic filariasis: perspectives on acute and chronic infection with Wuchereria bancrofti in south India. Parasite Immunol 23: 389399.[Crossref]
  2. de Almeida AB, Freedman DO, , 1999. Epidemiology and immunopathology of bancroftian filariasis. Microbes Infect 1: 10151022.[Crossref]
  3. Dreyer G, Norões J, Figueredo-Silva J, Piessens WF, , 2000. Pathogenesis of lymphatic disease in bancroftian filariasis: a clinical perspective. Parasitol Today 16: 544548.[Crossref]
  4. Stanilova SA, Slavov ES, , 2001. Comparative study of circulating immune complexes quantity detection by three assays-CIF-ELISA, C1q-ELISA and anti-C3 ELISA. J Immunol Methods 253: 1321.[Crossref]
  5. Høiby N, Döring G, Schiøtz PO, , 1986. The role of immune complexes in the pathogenesis of bacterial infections. Annu Rev Microbiol 40: 2953.[Crossref]
  6. Mathsson L, Lampa J, Mullazehi M, Rönnelid J, , 2006. Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells. Arthritis Res Ther 8: R64.[Crossref]
  7. Mathsson L, Tejde A, Carlson K, Höglund M, Nilsson B, Nilsson-Ekdahl K, Rönnelid J, , 2005. Cryoglobulin-induced cytokine production via FcgammaRIIa: inverse effects of complement blockade on the production of TNF-alpha and IL-10. Implications for the growth of malignant B-cell clones. Br J Haematol 129: 830838.[Crossref]
  8. Rönnelid JA, Tejde L, Mathsson L, Nilsson-Ekdahl K, Nilsson B, , 2003. Immune complexes from SLE sera induce IL-10 production from normal peripheral blood mononuclear cells by an FcγRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE. Ann Rheum Dis 62: 3742.[Crossref]
  9. Schifferli JA, , 1985. Elimination of immune complexes: role of complement. Schweiz Med Wochenschr 115: 14221424.
  10. Ralph C, , 1981. Immune complexes in human diseases. Annu Rev Med 32: 1328.[Crossref]
  11. Dixit V, Gupta AK, Bisen PS, Prasad GB, Harinath BC, , 2007. Serum immune complexes as diagnostic and therapeutic markers in lymphatic filariasis. J Clin Lab Anal 21: 114118.[Crossref]
  12. Ramaprasad P, Prasad GB, Harinath BC, , 1988. Microfilaraemia, filarial antibody, antigen and immune complex levels in human filariasis before, during and after DEC therapy. A two-year follow-up. Acta Trop 45: 245255.
  13. Kar SK, Mania J, Kar PK, , 1993. Humoral immune response during filarial fever in bancroftian filariasis. Trans R Soc Trop Med Hyg 87: 230233.[Crossref]
  14. Nath G, Mohapatra TM, Sen PC, , 1991. Circulating immune complexes and complement in bancroftian filariasis. Indian J Pathol Microbiol 34: 9298.
  15. Rao UR, Chandrashekar R, Subrahmanyam D, , 1987. Complement activation by eggs and microfilariae of filarial parasites. Immunol Cell Biol 65: 365370.[Crossref]
  16. Rees-Roberts D, Mullen LM, Gounaris K, Selkirk ME, , 2010. Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes. Int J Parasitol 40: 527532.[Crossref]
  17. Arora V, Verma J, Dutta R, Marwah V, Kumar A, Das N, , 2004. Reduced complement receptor 1 (CR1, CD35) transcription in systemic lupus erythematosus. Mol Immunol 41: 449456.[Crossref]
  18. Böyum A, , 1968. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl 97: 7789.
  19. Sisley BM, Mackenzie CD, Steward MW, Williams JF, O'Day J, Luty AJ, Braga M, el Sheik H, , 1987. Associations between clinical disease, circulating antibodies and C1q-binding immune complexes in human onchocerciasis. Parasite Immunol 9: 447463.[Crossref]
  20. Verroust PJ, Adam C, Smith MD, Richard-Lenoble D, Kourilsky O, Morel-Maroger LJ, , 1979. Circulating immune complexes and C3d in human parasitosis. Kidney Int 16: 914.[Crossref]
  21. Das MK, Subramanyam VR, Ravindran B, Pattnaik NM, , 1987. A study of the antigen, antibody and immunecomplex levels in Wuchereria bancrofti filariasis with reference to clinical status. J Trop Med Hyg 90: 135141.
  22. Carter T, Sumiya M, Reilly K, Ahmed R, Sobieszczuk P, Summerfield JA, Lawrence RA, , 2007. Mannose-binding lectin A-deficient mice have abrogated antigen-specific IgM responses and increased susceptibility to a nematode infection. J Immunol 178: 51165123.[Crossref]
  23. Choi EH, Zimmerman PA, Foster CB, Zhu S, Kumaraswami V, Nutman TB, Shanoch SJ, , 2001. Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India. Genes Immun 2: 248253.[Crossref]
  24. Meyrowitsch DW, Simonsen PE, Garred P, Dalgaard M, Magesa SM, Alifrangis M, , 2010. Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in North-Eastern Tanzania. Am J Trop Med Hyg 82: 115120.[Crossref]
  25. Colten HR, Alper CA, Rosen FS, , 1981. Genetics and biosynthesis of complement proteins. N Engl J Med 304: 653.[Crossref]
  26. Cochrane CG, , 1971. Mechanisms involved in the deposition of immune complexes in tissues. J Exp Med 134: 7589.[Crossref]
  27. King CH, Spagnuolo PJ, Greene PM, , 1983. Chemotaxis of human granulocytes toward microfilariae of Onchocerca volvulus . Parasite Immunol 5: 217224.[Crossref]
  28. Paganelli R, Ngu JL, Levinsky RJ, , 1980. Circulating immune complexes in onchocerciasis. Clin Exp Immunol 39: 570575.
  29. Dooley JL, Abdel-Latif D, St Laurent CD, Puttagunta L, Befus D, Lacy P, , 2009. Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury. Am J Physiol Lung Cell Mol Physiol 297: L1091L1102.[Crossref]
  30. Hurd ER, Hashimoto Y, , 1981. Human neutrophil swelling induced by immune complexes and aggregated IgG. Inflammation 5: 213222.[Crossref]
  31. Jarvis JN, Xu C, Wang W, Petty HR, Gonzalez M, Morssy N, Waxman F, Quintero del Rio A, , 1999. Immune complex size and complement regulate cytokine production by peripheral blood mononuclear cells. Clin Immunol 93: 274282.[Crossref]
  32. Babu S, Bhat SQ, Pavan Kumar N, Lipira AB, Kumar S, Karthik C, Kumaraswami V, Nutman TB, , 2009. Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells. PLoS Negl Trop Dis 3: e420.[Crossref]
  33. Babu S, Nutman TB, , 2003. Proinflammatory cytokines dominate the early immune response to filarial parasites. J Immunol 171: 67236732.[Crossref]
  34. Satapathy AK, Sartono E, Sahoo PK, Dentener MA, Michael E, Yazdanbakhsh M, Ravindran B, , 2006. Human bancroftian filariasis: immunological markers of morbidity and infection. Microbes Infect 8: 24142423.[Crossref]
  35. Babu S, Ganley LM, Klei TR, Shultz LD, Rajan TV, , 2000. Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi . Infect Immun 68: 30343035.[Crossref]
  36. Osawa H, Yamabe H, Kaizuka M, Nakamura N, Shirato K, , 2002. Platelet-derived growth factor stimulates matrix metalloproteinase-2 secretion in cultured human mesangial cells. Clin Exp Nephrol 6: 202206.[Crossref]
  37. Soehnlein O, Zernecke A, Eriksson EE, Rothfuchs AG, Pham CT, Herwald H, Bidzhekov K, Rottenberg ME, Webwe C, Lindbom L, , 2008. Neutrophil secretion products pave the way for inflammatory monocytes. Blood 112: 14611471.[Crossref]
  38. Semnani RT, Keiser PB, Coulibaly YI, Keita F, Diallo AA, Doumbo OK, Traore SF, Kubofcik J, Klion AD, Nutman TB, , 2006. Filaria-induced monocyte dysfunction and its reversal following treatment. Infect Immun 74: 44094417.[Crossref]
  39. Haapasalo K, Meri T, Jokiranta TS, , 2009. Loa loa microfilariae evade complement attack in vivo by acquiring regulatory proteins from host plasma. Infect Immun 77: 38863893.[Crossref]
  40. Freedman DO, de Almeido Filho PJ, Besh S, Maia e Silva MC, Braga C, Maciel A, Furtado AF, , 1995. Abnormal lymphatic function in presymptomatic bancroftian filariasis. J Infect Dis 171: 9971001.[Crossref]
  41. Freedman DO, de Almeida Filho PJ, Besh S, Maia e Silva MC, Braga C, Maciel A, , 1994. Lymphoscintigraphic analysis of lymphatic abnormalities in symptomatic and asymptomatic human filariasis. J Infect Dis 170: 927933.[Crossref]
  42. Shenoy RK, Suma TK, Kumaraswami V, Rahmah N, Dhananjayan G, Padma S, Abhilash G, Ramesh C, , 2007. Preliminary findings from a cross-sectional study on lymphatic filariasis in children, in an area of India endemic for Brugia malayi infection. Ann Trop Med Parasitol 101: 205213.[Crossref]
  43. Fox LM, Wilson SF, Addiss DG, Louis-Charles J, Beau de Rochars MV, Lammie PJ, , 2005. Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions. Am J Trop Med Hyg 73: 759765.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2011.11-0086
Loading
/content/journals/10.4269/ajtmh.2011.11-0086
Loading

Data & Media loading...

  • Received : 09 Feb 2011
  • Accepted : 13 Apr 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error