Volume 85, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The aim of this study is to investigate the changes in clinical pattern and therapeutic measures in leptospirosis-associated acute kidney injury; a retrospective study with 318 patients in Brazil. Patients were divided according to the time of admission: 1985–1996 (group I) and 1997–2010 (group II). Patients were younger in group I (36 ± 13 versus 41 ± 16 years, = 0.005) and the numbers of oliguria increased (21% versus 41% in group II, = 0.014). Higher frequency of lung manifestations was observed in group II ( < 0.0001). Although increased severity, there was a significant reduction in mortality (20% in group I versus 12% in group II, = 0.03). Mortality was associated with advanced age, low diastolic blood pressure, oliguria, arrhythmia, and peritoneal dialysis, besides a trend to better mortality with penicillin administration. Leptospirosis is occurring in an older population, with a higher number of oliguria and lung manifestations. However, mortality is decreasing and can be the result of changes in treatment.


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  • Received : 07 Feb 2011
  • Accepted : 16 Jun 2011
  • Published online : 01 Sep 2011

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