Volume 85, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A recent study by our group reported the isolation and partial serological and molecular characterization of four serogroup Ballum strains. Here, we reproduced experimental leptospirosis in golden Syrian hamsters () and carried out standardization of lethal dose 50% (LD50) of one of these strains (4E). Clinical disease features and histopathologic analyses of tissue lesions were also observed. As results, strain 4E induced lethality in the hamster model with inocula lower than 10 leptospires, and histopathological examination of animals showed typical lesions found in severe leptospirosis. Gross pathological findings were peculiar; animals that died early had more chance of presenting severe jaundice and less chance of presenting pulmonary hemorrhages ( < 0.01). serogroup Ballum has had a considerable growth in human leptospirosis cases in recent years. This strain has now been thoroughly characterized and can be used in more studies, especially evaluations of vaccine candidates.


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  • Received : 06 Jan 2011
  • Accepted : 25 Apr 2011

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