Volume 84, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Phase variation is a property unique of some serovar Typhi strains from Indonesia. Typhi isolates from Indonesia have been described that in addition to the phase 1 Hd flagellin gene contain a second flagellin gene named z66. Typhi isolates from Indonesia with a mutant Hd gene named Hj have also been described. Here, we have identified another flagellin gene of Typhi, named Ind, showing a closest homology with the flagellin gene of . The Ind gene was detected in 21.8% of the Typhi isolates from the East Indonesian archipelago, all of which contained the Hd gene. The Hj gene was not detected. The z66 gene was present in 15.4% of the isolates. The presence of these “foreign” flagellin genes could be associated with an increased risk for developing severe disease.


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  • Received : 22 Oct 2010
  • Accepted : 01 Dec 2010
  • Published online : 04 Mar 2011

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