1921
Volume 85, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We studied the prevalence of anemia during pregnancy and its relationship with low birth weight (LBW; birth weight < 2,500 g) in Benin. We analyzed 1,508 observations from a randomized controlled trial conducted from 2005 to 2008 showing equivalence on the risk of LBW between two drugs for Intermittent Preventive Treatment of malaria during pregnancy (IPTp). Despite IPTp, helminth prophylaxis, and iron and folic acid supplementations, the proportions of women with severe anemia (hemoglobin [Hb] concentration < 80 g/L) and anemia (Hb < 110 g/L) were high throughout pregnancy: 3.9% and 64.7% during the second and 3.7% and 64.1% during the third trimester, but 2.5% and 39.6% at the onset of labor, respectively. Compared with women without anemia (Hb ≥ 110 g/L) during the third trimester, women with severe anemia (Hb < 80 g/L) were at higher risk of LBW after adjustment for potential confounding factors (prevalence ratio [PR] = 2.8; 95% confidence interval [1.4–5.6]).

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2011-09-01
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References

  1. WHO, 1998. Global Database on Child Growth and Malnutrition. Geneva: WHO.
  2. van den Broek N, , 1998. Anaemia in pregnancy in developing countries. Br J Obstet Gynaecol 105: 385390.[Crossref]
  3. Klebanoff MA, Shiono PH, Berendes HW, Rhoads GG, , 1989. Facts and artifacts about anemia and preterm delivery. JAMA 262: 511515.[Crossref]
  4. Berkowitz GS, Papiernik E, , 1993. Epidemiology of preterm birth. Epidemiol Rev 15: 414443.[Crossref]
  5. Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E, , 2000. Anemia during pregnancy and birth outcome: a meta-analysis. Am J Perinatol 17: 137146.[Crossref]
  6. McCormick MC, , 1985. The contribution of low birth-weight to infant-mortality and childhood morbidity. N Engl J Med 312: 8290.[Crossref]
  7. Stanley FJ, Watson L, , 1992. Trends in perinatal mortality and cerebral palsy in Western Australia, 1967 to 1985. BMJ 304: 16581663.[Crossref]
  8. UNICEF, 2004. Low Birthweight: Country, Regional and Global Estimates. New York: UNICEF.
  9. DeMaeyer E, Adiels-Tegman M, , 1985. The prevalence of anaemia in the world. World Health Stat Q 38: 302316.
  10. van den Broek N, , 2003. Anaemia and micronutrient deficiencies. Br Med Bull 67: 149160.[Crossref]
  11. Briand V, Bottero J, Noel H, Masse V, Cordel H, Guerra J, Kossou H, Fayomi B, Ayemonna P, Fievet N, Massoughodji A, Cot M, , 2009. Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. J Infect Dis 200: 9911001.[Crossref]
  12. Ballard JL, Khoury JC, Wedig K, Wang L, Eilerswalsman BL, Lipp R, , 1991. New Ballard Score, expanded to include extremely premature-infants. J Pediatr 119: 417423.[Crossref]
  13. Spiegelman DHE, , 2005. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 162: 199200.[Crossref]
  14. Greenland S, Pearl J, Robins JM, , 1999. Causal diagrams for epidemiologic research. Epidemiology 10: 3748.[Crossref]
  15. Beaton GH, , 2000. Iron needs during pregnancy: do we need to rethink our targets? Am J Clin Nutr 72: 265S271S.
  16. Stephansson O, Dickman PW, Johansson A, Cnattingius S, , 2000. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA 284: 26112617.[Crossref]
  17. Xiong X, Buekens R, Fraser WD, Guo Z, , 2003. Anemia during pregnancy in a Chinese population. Int J Gynaecol Obstet 83: 159164.[Crossref]
  18. Chesley LC, , 1972. Plasma and red cell volumes during pregnancy. Am J Obstet Gynecol 112: 440.[Crossref]
  19. Hytten F, , 1985. Blood volume changes in normal pregnancy. Clin Haematol 14: 601612.
  20. Wingate MS, Alexander GR, Buekens P, Vahratian A, , 2007. Comparison of gestational age classifications: date of last menstrual period vs. clinical estimate. Ann Epidemiol 17: 425430.[Crossref]
  21. Yang H, Kramer MS, Platt RW, Blonel B, Bréart G, Morin I, Wilkins R, Usher R, , 2002. How does early ultrasound scan estimation of gestational age lead to higher rates of preterm birth? Am J Obstet Gynecol 186: 433437.[Crossref]
  22. Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD, , 2007. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7: 93104.[Crossref]
  23. Menendez C, Bardaji A, Sigauque B, Romagosa C, Sanza S, Serra-Casas E, Macete E, Berenguera A, David C, Dobaño C, Naniche D, Mayor A, Ordi J, Mandomando I, Aponte JJ, Mabunda S, Alonso PL, , 2008. A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic. PLoS ONE 3: e1934.[Crossref]
  24. Windham GC, Hopkins B, Fenster L, Swan SH, , 2000. Prenatal active or passive tobacco smoke exposure and the risk of preterm delivery or low birth weight. Epidemiology 11: 427433.[Crossref]
  25. Goldenberg RL, Culhane JF, Iams JD, Romero R, , 2008. Preterm birth 1: epidemiology and causes of preterm birth. Lancet 371: 7584.[Crossref]
  26. Berkowitz GS, Papiernik E, , 1993. Epidemiology of preterm birth. Epidemiol Rev 15: 414443.[Crossref]
  27. Kalilani LM, Chaponda M, Rogerson SJ, Meshnick SR, , 2010. The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia. Trans R Soc Trop Med Hyg 104: 416422.[Crossref]
  28. Achidi EA, Kuoh AJ, Minang JT, Ngum B, Achimbom BM, Motaze SC, Ahmadou MJ, Troye-Blomberg M, , 2005. Malaria infection in pregnancy and its effects on haemoglobin levels in women from a malaria endemic area of Fako Division, South West Province, Cameroon. J Obstet Gynaecol 25: 235240.[Crossref]
  29. Marchant T, Schellenberg J, Edgar T, Ronsmans C, Nathan R, Abdulla S, Mukasa O, Urassa H, Lengeler C, , 2002. Anaemia during pregnancy in southern Tanzania. Ann Trop Med Parasitol 96: 477487.[Crossref]
  30. van Eijk AM, Ayisi JG, Slutsker L, Ter Kuile FO, Rosen DH, Otieno JA, Shi YP, Kager PA, Steketee RW, , 2007. Effect of haematinic supplementation and malaria prevention on maternal anaemia and malaria in western Kenya. Trop Med Int Health 12: 342352.[Crossref]
  31. Watson-Jones D, Weiss HA, Changalucha JM, Todd J, Gumodoka B, Bulmer J, Balira R, Ross D, Mageye K, Hayes R, Mabey D, , 2007. Adverse birth outcomes in United Republic of Tanzania—impact and prevention of maternal risk factors. Bull World Health Organ 85: 918.[Crossref]
  32. Geelhoed D, Agadzi F, Visser L, Ablordeppey E, Asare K, O'Rourke P, Van Leeuwen JS, Van Roosmalen J, , 2006. Severe anemia in pregnancy in rural Ghana: a case-control study of causes and management. Acta Obstet Gynecol Scand 85: 11651171.[Crossref]
  33. Goodlin RC, Dobry CA, Anderson JC, Woods RE, Quaife M, , 1983. Clinical signs of normal plasma-volume expansion during pregnancy. Am J Obstet Gynecol 145: 10011009.[Crossref]
  34. Zhou LM, Yang WW, Hua JZ, Deng CQ, Tao X, Stoltzfus RJ, , 1998. Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. Am J Epidemiol 148: 9981006.[Crossref]
  35. Steer P, Alam MA, Wadsworth J, Welch A, , 1995. Relation between maternal hemoglobin concentration and birth weight in different ethnic groups. BMJ 310: 489491.[Crossref]
  36. Bhargava M, Kumar R, Iyer PU, Ramji S, Kapani V, Bhargava SK, , 1989. Effect of maternal anemia and iron depletion on fetal iron stores, birth weight and gestation. Acta Paediatr Scand 78: 321322.[Crossref]
  37. Bondevik GT, Lie RT, Ulstein M, Kvale G, , 2001. Maternal hematological status and risk of low birth weight and preterm delivery in Nepal. Acta Obstet Gynecol Scand 80: 402408.[Crossref]
  38. Villar J, Belizan JM, , 1982. The timing factor in the pathophysiology of the intrauterine growth retardation syndrome. Obstet Gynecol Surv 37: 499506.[Crossref]
  39. Wilcox A, , 2001. On the importance-and the unimportance-of birthweight. Int J Epidemiol 30: 12331241.[Crossref]
  40. Shulman CE, Marshall T, Dorman EK, Bulmer JN, Cutts F, Peshu N, Marsh K, , 2001. Malaria in pregnancy: adverse effects on haemoglobin levels and birthweight in primigravidae and multigravidae. Trop Med Int Health 6: 770778.[Crossref]
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  • Received : 21 Oct 2010
  • Accepted : 11 Jun 2011

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