1921
Volume 85, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We conducted a nested case-control study of placental malaria (PM) and mother-to-child transmission (MTCT) of human immunodeficiency virus-1 (HIV-1) within a prospective cohort of 627 mother-infant pairs followed from October 1989 until April 1994 in rural Rwanda. Sixty stored placentas were examined for PM and other placental pathology, comparing 20 HIV-infected mother-infant (perinatal transmitter) pairs, 20 HIV-uninfected pairs, and 20 HIV-infected mothers who did not transmit to their infant perinatally. Of 60 placentas examined, 45% showed evidence of PM. Placental malaria was associated with increased risk of MTCT of HIV-1 (adjusted odds ratio [aOR] = 6.3; 95% confidence interval [CI] = 1.4–29.1), especially among primigravidae (aOR = 12.0; 95% CI = 1.0–150; < 0.05). Before antiretroviral therapy or prophylaxis, PM was associated with early infant HIV infection among rural Rwandan women living in a hyper-endemic malaria region. Primigravidae, among whom malaria tends to be most severe, may be at higher risk.

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References

  1. UNAIDS, 2009. AIDS Epidemic Update 2009. Geneva: UNAIDS.
    [Google Scholar]
  2. WHO, 2008. World Malaria Report 2008. Geneva: World Health Organization.
    [Google Scholar]
  3. Abu-Raddad LJ, Patnaik P, Kublin JG, 2006. Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science 314: 16031606.[Crossref]
    [Google Scholar]
  4. ter Kuile FO, Parise ME, Verhoeff FH, Udhayakumar V, Newman RD, van Eijk AM, Rogerson SJ, Steketee RW, 2004. The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-Saharan Africa. Am J Trop Med Hyg 71: 4154.
    [Google Scholar]
  5. Guyatt HL, Snow RW, 2001. The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa. Am J Trop Med Hyg 64: 3644.
    [Google Scholar]
  6. Steketee RW, Wirima JJ, Bloland PB, Chilima B, Mermin JH, Chitsulo L, Breman JG, 1996. Impairment of a pregnant woman's acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1. Am J Trop Med Hyg 55: 4249.
    [Google Scholar]
  7. Chandramohan D, Greenwood BM, 1998. Is there an interaction between human immunodeficiency virus and Plasmodium falciparum? Int J Epidemiol 27: 296301.[Crossref]
    [Google Scholar]
  8. Kublin JG, Patnaik P, Jere CS, Miller WC, Hoffman IF, Chimbiya N, Pendame R, Taylor TE, Molyneux ME, 2005. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet 365: 233240.
    [Google Scholar]
  9. French N, Gilks CF, 2000. Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 18 March 1999. Fresh from the field: some controversies in tropical medicine and hygiene. HIV and malaria, do they interact? Trans R Soc Trop Med Hyg 94: 233237.[Crossref]
    [Google Scholar]
  10. Msamanga GI, Taha TE, Young AM, Brown ER, Hoffman IF, Read JS, Mudenda V, Goldenberg RL, Sharma U, Sinkala M, Fawzi WW, 2009. Placental malaria and mother-to-child transmission of human immunodeficiency virus-1. Am J Trop Med Hyg 80: 508515.
    [Google Scholar]
  11. Mwapasa V, Rogerson SJ, Molyneux ME, Abrams ET, Kamwendo DD, Lema VM, Tadesse E, Chaluluka E, Wilson PE, Meshnick SR, 2004. The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women. AIDS 18: 10511059.[Crossref]
    [Google Scholar]
  12. John GC, Nduati RW, Mbori-Ngacha DA, Richardson BA, Panteleeff D, Mwatha A, Overbaugh J, Bwayo J, Ndinya-Achola JO, Kreiss JK, 2001. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections. J Infect Dis 183: 206212.[Crossref]
    [Google Scholar]
  13. Inion I, Mwanyumba F, Gaillard P, Chohan V, Verhofstede C, Claeys P, Mandaliya K, Van Marck E, Temmerman M, 2003. Placental malaria and perinatal transmission of human immunodeficiency virus type 1. J Infect Dis 188: 16751678.[Crossref]
    [Google Scholar]
  14. Brahmbhatt H, Sullivan D, Kigozi G, Askin F, Wabwire-Mangenm F, Serwadda D, Sewankambo N, Wawer M, Gray R, 2008. Association of HIV and malaria with mother-to-child transmission, birth outcomes, and child mortality. J Acquir Immune Defic Syndr 47: 472476.[Crossref]
    [Google Scholar]
  15. Ayisi JG, van Eijk AM, Newman RD, ter Kuile FO, Shi YP, Yang C, Kolczak MS, Otieno JA, Misore AO, Kager PA, Lal RB, Steketee RW, Nahlen BL, 2004. Maternal malaria and perinatal HIV transmission, western Kenya. Emerg Infect Dis 10: 643652.[Crossref]
    [Google Scholar]
  16. Chao A, Bulterys M, Musanganire F, Habimana P, Nawrocki P, Taylor E, Dushimimana A, Saah A, 1994. Risk factors associated with prevalent HIV-1 infection among pregnant women in Rwanda. National University of Rwanda-Johns Hopkins University AIDS Research Team. Int J Epidemiol 23: 371380.[Crossref]
    [Google Scholar]
  17. Bulterys M, Chao A, Munyemana S, Kurawige JB, Nawrocki P, Habimana P, Kageruka M, Mukantabana S, Mbarutso E, Dushimimana A, Saah A, 1994. Maternal human immunodeficiency virus 1 infection and intrauterine growth: a prospective cohort study in Butare, Rwanda. Pediatr Infect Dis J 13: 94100.[Crossref]
    [Google Scholar]
  18. Weng S, Bulterys M, Chao A, Stidley CA, Dushimimana A, Mbarutso E, Saah A, 1998. Perinatal human immunodeficiency virus-1 transmission and intrauterine growth: a cohort study in Butare, Rwanda. Pediatrics 102: e24.[Crossref]
    [Google Scholar]
  19. Bulterys M, Chao A, Dushimimana A, Habimana P, Nawrocki P, Kurawige JB, Musanganire F, Saah A, 1993. Multiple sexual partners and mother-to-child transmission of HIV-1. AIDS 7: 16391645.[Crossref]
    [Google Scholar]
  20. Bulterys M, Farzadegan H, Nawrocki P, Dushimimana A, Chao A, Saah A, 1991. Detection of HIV-1 in breast milk by polymerase chain reaction: a cohort study. 6th International Conference on AIDS in Africa. Dakar, Senegal.
    [Google Scholar]
  21. Lee N, Baker J, Andrews KT, Gatton ML, Bell D, Cheng Q, McCarthy J, 2006. Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: implications for rapid diagnostic tests for malaria. J Clin Microbiol 44: 27732778.[Crossref]
    [Google Scholar]
  22. Mason DY, Sammons R, 1978. Alkaline phosphatase and peroxidase for double immunoenzymatic labeling of cellular constituents. J Clin Pathol 31: 454460.[Crossref]
    [Google Scholar]
  23. Ismail MR, Ordi J, Menendez C, Ventura PJ, Aponte JJ, Kahigwa E, Hirt R, Cardesa A, Alonso PL, 2000. Placental pathology in malaria: a histological, immunohistochemical, and quantitative study. Hum Pathol 31: 8593.[Crossref]
    [Google Scholar]
  24. Temmerman M, Nagelkerke N, Bwayo J, Chomba EN, Ndinya-Achola J, Piot P, 1995. HIV-1 and immunological changes during pregnancy: a comparison between HIV-1-seropositive and HIV-1-seronegative women in Nairobi, Kenya. AIDS 9: 10571060.[Crossref]
    [Google Scholar]
  25. Miotti PG, Liomba G, Dallabetta GA, Hoover DR, Chiphangwi JD, Saah AJ, 1992. T lymphocyte subsets during and after pregnancy: analysis in human immunodeficiency virus type 1-infected and -uninfected Malawian mothers. J Infect Dis 165: 11161119.[Crossref]
    [Google Scholar]
  26. Rogerson SJ, Mkundika P, Kanjala MK, 2003. Diagnosis of Plasmodium falciparum malaria at delivery: comparison of blood film preparation methods and of blood films with histology. J Clin Microbiol 41: 13701374.[Crossref]
    [Google Scholar]
  27. Ayouba A, Nerrienet E, Menu E, Lobé MM, Thonnon J, Leke RJ, Barré-Sinoussi F, Martin P, Cunin P, Yaounde MTCT Group, 2003. Mother-to-child transmission of human immunodeficiency virus type 1 in relation to the season in Yaounde, Cameroon. Am J Trop Med Hyg 69: 447449.
    [Google Scholar]
  28. Tkachuk AN, Moormann AM, Poore JA, Rochford RA, Chensue SW, Mwapasa V, Meshnick SR, 2001. Malaria enhances expression of CC chemokine receptor 5 on placental macrophages. J Infect Dis 183: 967972.[Crossref]
    [Google Scholar]
  29. Mwanyumba F, Gaillard P, Inion I, Verhofstede C, Claeys P, Chohan V, Vansteelandt S, Mandaliya K, Praet M, Temmerman M, 2002. Placental inflammation and perinatal transmission of HIV-1. J Acquir Immune Defic Syndr 29: 262269.[Crossref]
    [Google Scholar]
  30. Mofenson LM, 2010. Prevention in neglected subpopulations: prevention of mother-to-child transmission of HIV infection. Clin Infect Dis 50: S130S148.[Crossref]
    [Google Scholar]
  31. WHO/UNICEF, 2009. Children and AIDS: Fourth Stocktaking Report 2009. Geneva: World Health Organization.
    [Google Scholar]
  32. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI, 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434: 214217.[Crossref]
    [Google Scholar]
  33. Bulterys PL, Mharakurwa S, Thuma PE, 2009. Cattle, other domestic animal ownership, and distance between dwelling structures are associated with reduced risk of recurrent Plasmodium falciparum infection in southern Zambia. Trop Med Int Health 14: 522528.[Crossref]
    [Google Scholar]
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  • Received : 17 Oct 2010
  • Accepted : 22 Mar 2011
  • Published online : 01 Aug 2011

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