1921
Volume 84, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The therapeutic efficacy and effects of artemether-lumefantrine (AL) and artesunate-amodiaquine co-formulated (AAcf) or co-packaged (AAcp) on malaria-associated anemia (MAA) were evaluated in 285 children < 12 years of age with uncomplicated malaria randomized to receive one of the three drug combinations. Fever and parasite clearance times were similar in all treatment groups. Mean drug-attributable fall in hematocrit (DAFH), defined as difference between hematocrit values pre- and 3 d post- initiation of treatment, was low (< 4.5%) and rates of recovery from MAA were similar with all treatments. Mean areas under curve (AUCs) of the plot of deficit in hematocrit levels from 30% versus time in anemic children were similar in all groups. All regimens were well tolerated. AL, AAcf and AAcp cleared fever and parasitemia rapidly and had similar rates of resolution of MAA after treatment in malarious Nigerian children.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2011.10-0582
2011-05-05
2017-11-17
Loading full text...

Full text loading...

/deliver/fulltext/14761645/84/5/813.html?itemId=/content/journals/10.4269/ajtmh.2011.10-0582&mimeType=html&fmt=ahah

References

  1. White NJ, , 2008. Qinghaosu (artemisinin): the price of success. Science 320: 330334.[Crossref]
  2. World Health Organization, 2001. Antimalarial drug combination therapy. Report of a WHO Technical Consultation. Geneva, Switzerland: World Health Organization.
  3. Omari AA, Gamble C, Garner P, , 2004. Artemether-lumefantrine for uncomplicated malaria: a systematic review. Trop Med Int Health 9: 192199.[Crossref]
  4. Kamya MR, Yeka A, Burkiwa H, Lugemwa M, Rwankimari JB, Staedke SG, Talisuna AO, Greenhouse B, Nosten F, Rosenthal PJ, Wabwire-Mangen F, Dorsey G, , 2007. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials 2: e20.[Crossref]
  5. Falade C, Makanga M, Premji Z, Ortmann CE, Stockmeyer M, de Palcios PI, , 2005. Efficacy and safety of artemether-lumefantrine (Coartem) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 99: 459467.[Crossref]
  6. Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WRJ, , 2002. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomized, multicentre trial. Lancet 359: 13651372.[Crossref]
  7. Sowunmi A, Balogun T, Gbotosho GO, Happi CT, Adedeji AA, Fehintola FA, , 2007. Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and sexual-stage parasites in falciparum malaria in children. Antimicrob Agents Chemother 51: 16941699.[Crossref]
  8. Ndiaye JL, Milijaona R, Sagara I, Brasseur P, Ndiaye I, Faye B, Randrianasolo L, Ratsimbasoa A, Forlemu D, Moor VA, Traore A, Dicko Y, Dara N, Lameyre V, Diallo M, Djimde A, Same-Ekobo A, Gaye O, , 2008. Randomized multicentre assessment of the efficacy and safety of artesunate-amodiaquine-a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. Malar J 8: 125.[Crossref]
  9. Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O' Neil M, Milhous W, Wirth DF, Oduola AMJ, , 2009. Selection of Plasmodium falciparum multi-drug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria. Antimicrob Agents Chemother 53: 888895.[Crossref]
  10. Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AMJ, , 2006. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. Am J Trop Med Hyg 75: 155161.
  11. Salako LA, Ajayi FO, Sowunmi A, Walker O, , 1990. Malaria in Nigeria: a revisit. Ann Trop Med Parasitol 84: 435445.[Crossref]
  12. Sowunmi A, Gbotosho GO, Happi CT, Adedeji AA, Fehintola FA, Folarin OA, Tambo E, Fateye BA, , 2007. Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria. Am J Trop Med Hyg 77: 235241.
  13. World Health Organization, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Suppl 1): 190.
  14. Sowunmi A, Balogun ST, Gbotosho GO, Happi CT, , 2009. Effects of amoqiauine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children. Acta Trop 109: 5560.[Crossref]
  15. Sowunmi A, Gbotosho GO, Happi CT, Folarin O, Okuboyejo T, Micheal O, Fatunmbi B, , 2010. Use of area under the curve to evaluate the effects of antimalarial drugs on malaria-associated anemia after treatment. Am J Ther, July 30 [Epub ahead of print].
  16. Rowland M, Towzer TN, , 1980. Clinical Pharmacokinetics: Concepts and Applications. Philadelphia, PA: Lea & Febiger.
  17. World Health Organization, 1973. Chemotherapy of Malaria and Resistance to Antimalarials. Geneva: World Health Organization.
  18. World Health Organization, 2003. Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. Geneva, Switzerland: World Health Organization.
  19. Anonymous, 1994. Epi Info Version 6. A Word Processing Data Base and Statistics Program for Public Health on IBM-Compatible Microcomputers. Atlanta, GA: Centers for Disease Control and Prevention.
  20. Anonymous, 1999. SPSS for Windows Release 10.01 (Standard Version). Chicago, IL: SPSS Inc.
  21. Djimde AA, Doumbo OK, Traore O, Guindo AB, Kayentao K, Diourte Y, Niare-Dumbo S, Coulibaly D, Kone AK, Cissoko Y, Tekete M, Diallo DA, Wellems TE, Kwiatowski D, Plowe CV, , 2003. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am J Trop Med Hyg 69: 558563.
  22. Olliaro P, Mussano P, , 2003. Amodiaquine for treating malaria. Cochrane Database Syst Rev 2: CD000016.
  23. Price R, van Vugt M, Nosten F, Luxemburger C, Brockman A, Phaipun L, Chongsuphajaisiddhi T, White NJ, , 1998. Artesunate versus artemether for the treatment of recrudescent multi-drug resistant falciparum malaria. Am J Trop Med Hyg 59: 883888.
  24. Sowunmi A, Balogun ST, Gbotosho GO, Happi CT, , 2009. Plasmodium falciparum gametocyte sex ratios in symptomatic children treated with antimalarial drugs. Acta Trop 109: 108117.[Crossref]
  25. Sowunmi A, Nkogho OO, Okuboyejo TM, Gbotosho GO, Happi CT, Adewoye EO, , 2009. Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children. Malar J 8: 297.[Crossref]
  26. Ouédraogo AL, Bousema T, Schneider P, de Vlas SJ, Iboudo-Sanogo E, Cuzin-Ouattara N, Néblé I, Roeffen W, Verhave JP, Luty AJ, Sauerwein R, , 2009. Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmission. PLoS One 4: e8140.[Crossref]
  27. Bousema JT, Schneider P, Gougna LC, Drakeley CJ, Tostmann A, Houben R, Githure JI, Ord R, Sutherland CJ, Omar SA, Sauerwein RW, , 2006. Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum . J Infect Dis 193: 11511159.[Crossref]
  28. Price R, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen I, ter Kuile F, Chongsuphajaisiddhi T, White NJ, , 2001. Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg 65: 614622.
  29. Sowunmi A, Gbotosho GO, Happi CT, Fateye BA, , 2010. Factors contributing to anaemia after uncomplicated falciparum malaria in children. Acta Trop 113: 155161.[Crossref]
  30. Chotivanich K, Udomsangpetch R, Dondorp A, Williams T, Angus B, Simpson JA, Pukrittayakamee S, Looaresuwan S, Newbold CI, White NJ, , 2000. The mechanism of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. J Infect Dis 182: 629633.[Crossref]
  31. Newton PN, Chotivanich K, Cheirakul W, Ruangveerayuth R, Teerapong P, Silamut K, Looareesuwan S, White NJ, , 2001. A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and-negative erythrocytes. Blood 15: 450457.[Crossref]
  32. Sowunmi A, Walker O, Salako LA, , 1989. Pruritus and antimalarial drugs in Africans. Lancet 2: 213.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2011.10-0582
Loading
/content/journals/10.4269/ajtmh.2011.10-0582
Loading

Data & Media loading...

  • Received : 13 Oct 2010
  • Accepted : 15 Jan 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error