Volume 84, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Nitroimidazole antibiotics are the mainstay of treatment of invasive amebiasis; however, few comparative studies of applicable antibiotics are available. Evidence of sporadic clinical failure and rare reports of metronidazole resistance have led to the investigation of novel antiamebic therapeutics. The goal of this study was to examine drug efficacy in both and models of intestinal amebiasis. We studied six current and three novel drugs. Many drugs, including metronidazole, nitazoxanide, and nitazoxanide derivatives, were shown to be potently inhibitory . However, metronidazole remained the most effective , both in preventative and curative regimens, underscoring the value of animal models in evaluating future therapies.


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  • Received : 13 Oct 2010
  • Accepted : 05 Nov 2010

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