1921
Volume 85, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Post kala-azar dermal leishmaniasis (PKDL) and mucosal leishmaniasis (ML) are serious clinical forms of leishmaniasis caused by parasites in Sudan. Although pentavalent antimonys are used as the first line of treatment of all clinical forms of leishmaniasis, persistent PKDL and ML patients are treated with liposomal amphotericin B (Ambisome) as a second-line drug. In this work, we report the development of allergic reactions by a PKDL and a ML Sudanese patient to Ambisome. The findings warrant future close supervision of patients to be treated with the drug.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2011.10-0511
2011-10-01
2017-09-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/85/4/644.html?itemId=/content/journals/10.4269/ajtmh.2011.10-0511&mimeType=html&fmt=ahah

References

  1. Elhassan AM, Zijlstra EE, , 2001. Leishmaniasis in Sudan: mucosal leishmaniasis. Trans R Soc Trop Med Hyg 95 (Suppl 1): S19S26.[Crossref]
  2. Zijlstra EE, el-Hassan AM, , 2001. Leishmaniasis in Sudan. Post kala-azar dermal leishmaniasis. Trans R Soc Trop Med Hyg 95 (Suppl 1): S59S76.[Crossref]
  3. Berman J, , 2003. Current treatment approaches to leishmaniasis. Curr Opin Infect Dis 16: 397401.[Crossref]
  4. Malani PN, Depestel DD, Riddell J, Bickley S, Klein LR, Kauffman CA, , 2005. Experience with community-based amphotericin B infusion therapy. Pharmacotherapy 25: 690697.[Crossref]
  5. Collazos J, Marteniz E, Mayo J, Ibbara S, , 2001. Pulmonary reactions during treatment with amphotericin B: review of published cases and guidelines for management. Clin Infect Dis 33: E75E82.[Crossref]
  6. Moen MD, Lyseng-Williamson KA, Scott LJ, , 2009. Liposomal amphotericin B: a review of its use as empirical therapy in febrile neutropenia and in the treatment of invasive fungal infections. Drugs 69: 361392.[Crossref]
  7. Bates CM, Carey PB, Hind CR, , 1995. Anaphylaxis due to liposomal amphotericin (AmBisome). Genitourin Med 71: 414.
  8. Laing RB, Milne LJ, Leen CL, Malcolm GP, Steers AJ, , 1994. Anaphylactic reactions to liposomal amphotericin. Lancet 344: 682.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2011.10-0511
Loading
/content/journals/10.4269/ajtmh.2011.10-0511
Loading

Data & Media loading...

  • Received : 10 Sep 2010
  • Accepted : 08 Jun 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error