1921
Volume 84, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

meningitis was first reported in Cuba in 1981, and it was recently reported in South America. The aim of this paper is to evaluate the intrathecal immunoglobulin synthesis patterns from Cuba's and Ecuador's patients with angiostrongyliasis; 8 Ecuadorian patients from two different outbreaks and 28 Cuban patients were studied. Simultaneous blood and cerebrospinal fluid simples were taken. Immunoglobulin (Ig) A, IgM, IgG, and albumin were quantified by radial immunodiffusion. Corresponding Reibergrams were applied. A three-Ig pattern was the most frequent in the two groups, but IgM was presented in all Ecuadorian young mature patients; however, in the Cuban children, only 12 of 28 patients had intrathecal IgM, but about 90% had an IgA and IgG synthesis at time of later puncture. This indicates that, with a larger amount of parasites ingested, clinical symptoms are more severe, and a higher frequency of intrathecal IgM synthesis could be observed. This is discussed as a similarity with the intrathecal IgM synthesis in African trypanosomiasis.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2011.10-0500
2011-03-04
2019-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/84/3/406.html?itemId=/content/journals/10.4269/ajtmh.2011.10-0500&mimeType=html&fmt=ahah

References

  1. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiú-fanego R, , 2009. Activación y biosíntesis intratecal de C3c en niños con meningoencefalitis eosinofílica por Angiostrongylus cantonensis . Rev Neurol 48: 632635. [Google Scholar]
  2. Qiao PW, De HL, Xing QZ, Xiao GC, Zhao RL, , 2008. Human angiostrongyliasis. Lancet Infect Dis 8: 621630.[Crossref] [Google Scholar]
  3. Dorta-Contreras AJ, , 2001. Meningoencefalitis eosinofílica en Cuba. Rev Neurol 32: 9991000. [Google Scholar]
  4. Raccurt C, Balaise J, Durette DMC, , 2003. Présence d'Angiostrongylus cantonensis en Haïti. Trop Med Int Health 8: 423426.[Crossref] [Google Scholar]
  5. Anderson E, Gubler DJ, Sorensen K, Beddard J, Ash LR, , 1986. First report of Angiostrongylus cantonensis in Puerto Rico. Am J Trop Med Hyg 35: 319322. [Google Scholar]
  6. Lindo JF, Waugh C, Hall J, Cunningham MC, Ashley D, Eberhard ML, , 2002. Enzootic Angiostrongylus cantonensis in rat and snails after an outbreak of human eosinophilic meningitis, Jamaica. Emerg Infect Dis 8: 324326.[Crossref] [Google Scholar]
  7. Vargas M, Gómez PJD, Malek EA, , 1992. First record of A. cantonensis (Chen, 1935). Nematode: metastrongyloidae in the Dominican Republic. Trop Med Parasitol 43: 253255. [Google Scholar]
  8. Chikweto A, Bhaiyat MI, Macpherson CNL, DeAllie C, Pinckney RD, Richards C, Sharma RN, , 2009. Existence of Angiostrongylus cantonensis in rats (Rattus norvegicus) in Grenada, West Indies. Vet Parasitol 162: 160162.[Crossref] [Google Scholar]
  9. Campbell BG, Little MD, , 1998. The finding of Angiostrongylus cantonensis in rats in New Orleans. Am J Trop Med Hyg 38: 568573. [Google Scholar]
  10. Hochberg NS, Park SY, Blackburn BG, Sejvar JJ, Gaynor K, Cheng H, , 2007. Distribution of eosinophilic meningitis cases attributable to Angiostrongylus cantonensis, Hawaii. Emerg Infect Dis 13: 16751680.[Crossref] [Google Scholar]
  11. Pincay T, García L, Narváez E, Decker O, Martini L, Moreira JM, , 2009. Angiostrongiliasis due to Parastrongylus (Angiostrongylus) cantonensis in Ecuador. First report in South America. Trop Med Int Health 14 (Suppl 2): 37. [Google Scholar]
  12. Aguiar PH, Morera P, Pascual J, , 1981. First record of Angiostrongylus cantonensis in Cuba. Am J Trop Med Hyg 30: 963965. [Google Scholar]
  13. Pincay T, García L, Narváez E, Decker O, Martini L, Moreira JM, , 2009. Angiostrongiliasis por Parastrongylus (Angiostrongylus) cantonensis en Ecuador. Bol Epidemiol (Ecuador) 52: 2532. [Google Scholar]
  14. Graeff TC, , 2007. Expansion of Achatina fulica in Brazil and potential increased risk for angiostrongyliasis. Trans R Soc Trop Med Hyg 8: 743744.[Crossref] [Google Scholar]
  15. Reiber H, , 1994. Flow rate of cerebrospinal fluid (CSF): a concept common to normal blood–CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 122: 189203.[Crossref] [Google Scholar]
  16. Reiber H, , 1994. The hyperbolic function: a mathematical solution of the protein flux/CSF flow model for blood–CSF barrier function. J Neurol Sci 126: 243245.[Crossref] [Google Scholar]
  17. Reiber H, , 1998. Cerebrospinal fluid—physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases. Mult Scler 4: 99107.[Crossref] [Google Scholar]
  18. Reiber H, Peter JB, , 2001. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 184: 101122.[Crossref] [Google Scholar]
  19. Dorta Contreras AJ, Reiber H, , 1998. Intrathecal synthesis of immunoglobulins in eosinophilic meningoencephalitis due to Angiostrongylus cantonensis . Clin Diagn Lab Immunol 5: 452455. [Google Scholar]
  20. Lejon V, Reiber H, Legros D, Djé N, Magnus E, Woulters I, Sindic CJM, Büscher P, , 2003. Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis. J Infect Dis 187: 14751483.[Crossref] [Google Scholar]
  21. Dorta-Contreras AJ, , 2001. Reibergrama como herramienta epidemiológica: nuevo enfoque. Rev Neurol 33: 3640. [Google Scholar]
  22. Dorta-Contreras AJ, , 2006. Pattern of intrathecal immunoglobulin synthesis in pediatric patients with infectious meningoencephalitis. Biotecnol Apl 4: 382386. [Google Scholar]
  23. Dorta Contreras AJ, Agüero Valdés E, Escobar Pérez X, Noris García E, Ferrá Valdés M, , 1999. Respuesta inmune humoral intratecal en pacientes pediátricos con meningoencefalitis por Coxsackie B 5. Rev Neurol 28: 739741. [Google Scholar]
  24. Dorta-Contreras AJ, , 2001. Ausencia de anticuerpos anticisticercos en líquido cefalorraquídeo de pacientes pediátricos cubanos con convulsiones. Rev Neurol 32: 597600. [Google Scholar]
  25. Reiber H, , 2003. Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics. Restor Neurol Neurosci 21: 7996. [Google Scholar]
  26. Dorta-Contreras AJ, Reiber H, , 2004. Teoría de la difusión molecular/flujo del líquido cefalorraquídeo. Rev Neurol 39: 564569. [Google Scholar]
  27. Dorta-Contreras AJ, Núñez-Fernández FA, Pérez MO, Lastre GM, Magraner-Tarrau ME, Bu-Coifiú-Fanego R, Noris-García E, Padilla-Docal B, , 2007. Peculiaridades de la meningoencefalitis por Angiostrongylus cantonensis en América. Rev Neurol 12: 755763. [Google Scholar]
  28. Dorta-Contreras AJ, Noris-García E, Padilla-Docal B, Rodríguez-Rey A, González-Hernández M, Magraner-Tarrau ME, Bu-Coifiu-Fanego R, Reiber H, Interián-Morales MT, Sánchez-Zulueta E, Martínez-Delgado JF, Plana-Bouly R, Aguiar-Prieto PH, Núñez-Fernández FA, Pérez-Martín O, Lastre-González M, Alfonso-Manzanet E, , 2006. Aportes cubanos al estudio del Angiostrongylus cantonensis. Ciudad de la Habana, Cuba: Academia, 176. [Google Scholar]
  29. Bisser S, Lejon V, Proux PH, Bouteille B, Stanghellini A, Jauberteau MO, Buscher P, Dumas M, , 2002. Blood–cerebrospinal fluid barrier and intrathecal immunoglobulin compared to field diagnosis of control nervous system involvement in sleeping sickness. J Neurol Sci 193: 127135.[Crossref] [Google Scholar]
  30. Cortioux B, Bisser S, , 2009. Patrones de la neuroinflamación en la tripanosomiasis Africana. Neuroinmunología Clínica. Havana, Cuba: Editorial Academia, 93104. [Google Scholar]
  31. Lejon V, Jo R, Francois X, N'siesi DM, Hoogstoel A, Bisser S, Reiber H, Boelaert M, Buscher P, , 2007. Treatment failure related to intrathecal immunoglobulin M (IgM) synthesis, cerebrospinal fluid IgM, and interleukin-10 in patients with hemolymphatic-stage sleeping sickness. Clin Vaccine Immunol 14: 732737.[Crossref] [Google Scholar]
  32. Lambert PH, Berney M, Kazyumba G, , 1981. Immune complexes in serum and in cerebrospinal fluid in African trypanosomiasis. J Clin Invest 67: 7785.[Crossref] [Google Scholar]
  33. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiú-Fanego R, Rodríguez-Rey A, Gutiérrez-Hernández JC, de Paula-Almeida OS, , 2010. Reibergram of intrathecal synthesis of C4 in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis . Am J Trop Med Hyg 6: 10941098.[Crossref] [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2011.10-0500
Loading
/content/journals/10.4269/ajtmh.2011.10-0500
Loading

Data & Media loading...

  • Received : 08 Sep 2010
  • Accepted : 01 Dec 2010
  • Published online : 04 Mar 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error