1921
Volume 85, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. We performed a prospective age-stratified study in outpatient clinics investigating the prevalence of DF; 578 patients were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48–56%), DF was diagnosed in 8% (46/578, 95% CI = 6–10%), and 40% (95% CI = 36–44%) had neither diagnosis. Among the 317 malaria RDT-negative patients, 14% (45/317, 95% CI = 10–18%) had DF. The seroprevalence of dengue immunoglobulin G (IgG) was 83% (204/247, 95% CI = 78–87%), and no dengue hemorrhagic fever was seen. This study provides good evidence for the first time that DF is common in PNG and is responsible for 8% of fever episodes. The common occurrence of DF in a population with presumed previous exposure to dengue is an important observation.

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References

  1. Gubler D, Zaki S, 1998. Dengue and other viral hemorrhagic fevers. Nelson AM, Horsburgh CR, eds. Pathology of Emerging Infections. Washington, DC: ASM Press.
    [Google Scholar]
  2. World Health Organization, 2009. Dengue WHO: Guidelines for the Diagnosis, Treatment, Prevention, and Control. Geneva, Switzerland: World Health Organization.
    [Google Scholar]
  3. Deen JL, Harris E, Wills B, Balmaseda A, Hammond SN, Rocha C, Dung NM, Hung NT, Hien TT, Farrar JJ, 2006.The WHO dengue classification and case definitions: time for a reassessment. Lancet 368: 170173.[Crossref]
    [Google Scholar]
  4. Shibani B, Lucy CSL, Axel K, 2006. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health 11: 12381255.[Crossref]
    [Google Scholar]
  5. Raymond CSS, Eng Eong O, Hwee Bee W, Nicholas IP, 2005. An outbreak of primary dengue infection among migrant Chinese workers in Singapore characterized by prominent gastrointestinal symptoms and a high proportion of symptomatic cases. J Clin Virology 33: 336340.[Crossref]
    [Google Scholar]
  6. McBride WJ, Mullner H, LaBrooy JT, Wronski I, 1998. The 1993 dengue 2 epidemic in Charters Towers, North Queensland: clinical features and public health impact. Epidemiol Infect 121: 151156.[Crossref]
    [Google Scholar]
  7. Halstead S, 2003. Neutralization and antibody-dependent enhancement of dengue viruses. Adv Virus Res 60: 421467.[Crossref]
    [Google Scholar]
  8. Kuno G, 2009. Emergence of the severe syndrome and mortality associated with dengue and dengue-like illness: historical records (1890 to 1950) and their compatibility with current hypotheses on the shift of disease manifestation. Clin Microbiol Rev 22: 186201.[Crossref]
    [Google Scholar]
  9. Halstead S, Nimmannitya S, Yamarat C, Russell P, 1967. Hemorrhagic fever in Thailand; recent knowledge regarding etiology. Jpn J Med Sci Biol Dec(20 Suppl): 96103.
    [Google Scholar]
  10. Russell PK, Yuill TM, Nisalak A, Udomsakdi S, Gould DJ, Winter PE, 1968. An insular outbreak of dengue hemorrhagic fever: II. Virologic and serologic studies. Am J Trop Med Hyg 17: 600608.
    [Google Scholar]
  11. Morens D, 1994. Antibody-dependent enhancement of infection and the pathogenesis of viral disease. Clin Infect Dis 19: 500512.[Crossref]
    [Google Scholar]
  12. Stephens H, 2010. HLA and other gene associations with dengue disease severity. Curr Top Microbiol Immunol 338: 99114.
    [Google Scholar]
  13. Bouldouyre MA, Baumann F, Berlioz-Arthaud A, Chungue E, Lacassin F, 2006. Factors of severity at admission during an epidemic of dengue 1 in New Caledonia (South Pacific) in 2003. Scand J Infect Dis 38: 675681.[Crossref]
    [Google Scholar]
  14. Nuegoonpipat A, Berlioz-Arthaud A, Chow V, Endy T, Lowry K, Mai le Q, Ninh TU, Pyke A, Reid M, Reynes JM, Su Yun ST, Thu HM, Wong SS, Holmes EC, Aaskov J, 2004. Sustained transmission of dengue virus type 1 in the Pacific due to repeated introductions of different Asian strains. Virology 329: 505512.[Crossref]
    [Google Scholar]
  15. Rodhain F, Gaxotte P, Boutonnier A, 1980. Results of an entomological survey of mosquitoes (diptera:Culicidae) in Hermit Islands and Wuvulu Island (Papua, New Guinea). Bull Soc Pathol Exot 73: 214219.
    [Google Scholar]
  16. Wang E, Ni H, Xu R, Barrett AD, Watowich SJ, Gubler DJ, Weaver SC, 2000. Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J Virol 74: 32273234.[Crossref]
    [Google Scholar]
  17. Zigas VDR, 1973. An outbreak of dengue in the Rabaul community. P N G Med J 16: 4245.
    [Google Scholar]
  18. Gaxotte P, Rodhain F, Ardoin P, Hannoun C, 1975. A sero-epidemiologic survey on arbovirus in Wuvulu Island. Trop Geogr Med 27: 405408.
    [Google Scholar]
  19. Kiedrzynski T, Souarès Y et al., , 1995. Dengue in the Pacific: an updated story. Pacific Health Dialog 5: 129136.
    [Google Scholar]
  20. Hanna JNRS, Richards AR, Taylor CT, Pyke AT, Montgomery BL, Piispanen JP, Morgan AK, Humphreys JL, 2006. Multiple outbreaks of dengue serotype 2 in north Queensland. Aust N Z J Public Health 30: 220225.[Crossref]
    [Google Scholar]
  21. Richards AL, Bagus R, Baso SM, Follows GA, Tan R, Graham RR, Sandjaja B, Corwin AL, Punjabi N, 1997. The first reported outbreak of dengue hemorrhagic fever in Irian Jaya, Indonesia. Am J Trop Med Hyg 57: 4955.
    [Google Scholar]
  22. Cuzzubbo AJ, Vaughn DW, Nisalak A, Solomon T, Kalayanarooj S, Aaskov J, Dung NM, Devine PL, 2000. Comparison of PanBio dengue duo IgM and IgG capture ELISA and venture technologies dengue IgM and IgG dot blot. J Clin Virol 16: 135144.[Crossref]
    [Google Scholar]
  23. Porter KR, Widjaja S, Lohita HD, Hadiwijaya SH, Maroef CN, Suharyono W, Tan R, 1999. Evaluation of a commercially available immunoglobulin M capture enzyme-linked immunosorbent assay kit for diagnosing acute dengue infections. Clin Diagn Lab Immunol 6: 741744.
    [Google Scholar]
  24. Vaughn DW, Nisalak A, Kalayanarooj S, Solomon T, Dung NM, Cuzzubbo A, Devine PL, 1998. Evaluation of a rapid immunochromatographic test for diagnosis of dengue virus infection. J Clin Microbiol 36: 234238.
    [Google Scholar]
  25. Watanaveeradej V, Endy TP, Samakoses R, Kerdpanich A, Simasathien S, Polprasert N, Aree C, Vaughn DW, Ho C, Nisalak A, 2003. Transplacentally tranferred maternal-infant antibodies to dengue virus. Am J Trop Med Hyg 69: 123128.
    [Google Scholar]
  26. Chau TN, Hieu NT, Anders KL, Wolbers M, Lien le B, Hieu LT, Hien TT, Hung NT, Farrar J, Whitehead S, Simmons CP, 2009. Dengue virus infections and maternal antibody decay in a prospective birth cohort study of Vietnamese infants. J Infect Dis 200: 18931900.[Crossref]
    [Google Scholar]
  27. Vallée J, Dubot-Pérès A, Ounaphom P, Sayavong C, Bryant J, Gonzalez J, 2009. Spatial distribution and risk factors of dengue and Japanese encephalitis virus infection in urban settings: the case of Vientiane, Lao PDR. Trop Med Int Health 14: 11341142.[Crossref]
    [Google Scholar]
  28. Darcy A, Clothier H, Phillips D, Bakote'e B, Stewart T, 2001. Solomon Islands dengue seroprevalence study–previous circulation of dengue confirmed. P N G Med J 44: 4347.
    [Google Scholar]
  29. Pengsaa K, Limkittikul K, Luxemburger C, Yoksan S, Chambonneau L, Ariyasriwatana C, Lapphra K, Chanthavanich P, Lang J, Sabchareon A, 2008. Age-specific prevalence of dengue antibodies in Bangkok infants and children. Pediatr Infect Dis J 27: 461463.[Crossref]
    [Google Scholar]
  30. Hanson J, Taylor C, Richards A, Smith I, Boutlis C, 2004. Japanese encephalitis acquired near Port Moresby: implications for residents and travellers to Papua New Guinea. Med J Aust 181: 282283.
    [Google Scholar]
  31. Johansen CA, van den Hurk AF, Ritchie SA, Zborowski P, Nisbet DJ, Paru R, Bockarie MJ, Macdonald J, Drew AC, Khromykh TI, Mackenzie JS, 2000. Isolation of Japanese encephalitis virus from mosquitoes (Diptera: Culicidae) collected in the Western Province of Papua New Guinea, 1997–1998. Am J Trop Med Hyg 62: 631638.
    [Google Scholar]
  32. James A, 2008. Potts ALR. Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations. Trop Med Int Health 13: 13281340.[Crossref]
    [Google Scholar]
  33. Schexneider KI, Reedy EA, 2005. Thrombocytopenia in dengue fever. Curr Hematol Rep 4: 145148.[Crossref]
    [Google Scholar]
  34. Tanner L, Schreiber M, Low JG, Ong A, Tolfvenstam T, Lai YL, Ng LC, Leo YS, Thi Puong L, Vasudevan SG, Simmons CP, Hibberd ML, Ooi EE, 2008. Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness. PLoS Negl Trop Dis 2: e196.[Crossref]
    [Google Scholar]
  35. Gregory CJ, Santiago LM, Arguello DF, Hunsperger E, Tomashek KM, 2010. Clinical and laboratory features that differentiate dengue from other febrile illnesses in an endemic area—Puerto Rico, 2007–2008. Am J Trop Med Hyg 82: 922929.[Crossref]
    [Google Scholar]
  36. Halstead SB, Streit TG, Lafontant JG, Putvatana R, Russell K, Sun W, Kanesa-Thasan N, Hayes CG, Watts DM, 2001. Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission. Am J Trop Med Hyg 65: 180183.
    [Google Scholar]
  37. Halstead SB, 2008. Dengue. London: Imperial College Press.[Crossref]
    [Google Scholar]
  38. Rodhain F, Gaxotte P, 1977. An entomological survey on the mosquitoes of Wuvulu Island, Papua-New Guinea. Southeast Asian J Trop Med Public Health 8: 7779.
    [Google Scholar]
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  • Received : 30 Aug 2010
  • Accepted : 27 Mar 2011
  • Published online : 01 Jul 2011
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