Volume 84, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



In the past decades, cases of canine ocular onchocercosis have been reported worldwide, particularly in the United States and Europe. , originally described from a wolf, has been implicated in some of these cases, and its zoonotic role has been hypothesized on the basis of the reexamination of two cases of human ocular onchocerciasis. In the present study, we describe, for the first time, the occurrence of in the subconjunctival region of the human eye in a patient from Turkey. The nematode was identified as based on its morphology and molecular phylogenetic analysis of partial 1 and 12S ribosomal DNA genes. The results suggest that should be considered in the differential diagnosis of other eye parasitic infections in humans. The role of dogs as natural hosts of and the vectors of this zoonotic parasite need to be investigated.


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  1. Orihel TC, Eberhard ML, , 1998. Zoonotic filariasis. Clin Microbiol Rev 11: 366381. [Google Scholar]
  2. Pisella PJ, Assaraf E, Rossaza C, Limon S, Baudouin C, Richard-Lenoble D, , 1999. Conjunctivitis and ocular parasitic diseases. J Fr Ophtalmol 22: 585588. [Google Scholar]
  3. Shen J, Gasser RB, Chu D, Wang Z, Yuan X, Cantacessi C, Otranto D, , 2006. Human thelaziosis—a neglected parasitic disease of the eye. J Parasitol 92: 872875.[Crossref] [Google Scholar]
  4. Anderson RC, , 2000. Nematode Parasites of Vertebrates—Their Development and Transmission. New York: CAB International, 417422.[Crossref] [Google Scholar]
  5. Basáñez MG, Pion SD, Churcher TS, Breitling LP, Little MP, Boussinesq M, , 2006. River blindness: a success story under threat? PLoS Med 3: e371.[Crossref] [Google Scholar]
  6. Richards FO, Boatin B, Sauerbrey M, Seketeli A, , 2001. Control of onchocerciasis today: status and challenges. Trends Parasitol 17: 558563.[Crossref] [Google Scholar]
  7. Sréter T, Széll Z, , 2008. Onchocercosis: a newly recognized disease in dogs. Vet Parasitol 151: 113.[Crossref] [Google Scholar]
  8. Uni S, Boda T, Daisaku K, Ikura Y, Maruyama H, Hasegawa H, Fukuda M, Takaoka H, Bain O, , 2010. Zoonotic filariasis caused by Onchocerca dewittei japonica in a resident of Hiroshima Prefecture, Honshu, Japan. Parasitol Int 59: 477480.[Crossref] [Google Scholar]
  9. Burr WE, Jr Brown MF, Eberhard ML, , 1998. Zoonotic Onchocerca (Nematoda:Filarioidea) in the cornea of a Colorado resident. Ophthalmology 105: 14941497.[Crossref] [Google Scholar]
  10. Koehsler M, Soleiman A, Aspöck H, Auer H, Walochnik J, , 2007. Onchocerca jakutensis filariasis in humans. Emerg Infect Dis 13: 17491752.[Crossref] [Google Scholar]
  11. Orihel TC, Ash LR, Holshuh HJ, Santenelli S, , 1991. Onchocerciasis in a California dog. Am J Trop Med Hyg 44: 513517. [Google Scholar]
  12. Eberhard ML, Ortega Y, Dial S, Schiller CA, Sears W, Greiner E, , 2000. Ocular Onchocerca infections in western United States. Vet Parasitol 90: 333338.[Crossref] [Google Scholar]
  13. Zarfoss MK, Dubielzig RR, Eberhard ML, Schmidt KS, , 2005. Canine ocular onchocerciasis in the United States: two new cases and a review of the literature. Vet Ophthalmol 8: 5157.[Crossref] [Google Scholar]
  14. Széll Z, Erdélyi I, Sréter T, Albert M, Varga I, , 2001. Canine ocular onchocercosis in Hungary. Vet Parasitol 97: 245251.[Crossref] [Google Scholar]
  15. Komnenou A, Eberhard ML, Kaldrymidou E, Tsalie E, Dessiris A, , 2002. Subconjunctival filariasis due to Onchocerca sp. in dogs: report of 23 cases in Greece. Vet Ophthalmol 5: 119126.[Crossref] [Google Scholar]
  16. Hermosilla A, Hetzel U, Bausch M, Grübl J, Bauer C, , 2005. First autochthonous case of canine ocular onchocercosis in Germany. Vet Rec 154: 450452.[Crossref] [Google Scholar]
  17. Sréter-Lancz Z, Széll Z, Sréter T, , 2007. Molecular genetic comparison of Onchocerca sp. infecting dogs in Europe with other spirurid nematodes including Onchocerca lienalis . Vet Parasitol 148: 365370.[Crossref] [Google Scholar]
  18. Faísca P, Morales-Hojas R, Alves M, Gomes J, Botelho M, Melo M, Xufre A, , 2010. A case of canine ocular onchocercosis in Portugal. Vet Ophthalmol 13: 117121.[Crossref] [Google Scholar]
  19. Sréter T, Széll Z, Egyed Z, Varga I, , 2002. Subconjunctival zoonotic onchocercosis in man: aberrant infection with Onchocerca lupi? Ann Trop Med Parasitol 96: 497502.[Crossref] [Google Scholar]
  20. Pampiglione S, Vakalis N, Lyssimachou A, Kouppari G, Orihel TC, , 2001. Subconjunctival zoonotic Onchocerca in an Albanian man. Ann Trop Med Parasitol 95: 827832.[Crossref] [Google Scholar]
  21. Demiaszkiewicz AW, Matsaberidze GV, Kvavadze ES, , 1991. The female of Onchocerca lupi Rodonaja, 1967 under a scanning electron microscope. Acta Parasitol 36: 183186. [Google Scholar]
  22. Egyed Z, Sréter T, Széll Z, Beszteri B, Oravecz O, Màrialigeti K, Varga I, , 2001. Morphologic and genetic characterization of Onchocerca lupi infecting dogs. Vet Parasitol 102: 309319.[Crossref] [Google Scholar]
  23. Casiraghi M, Bain O, Guerrero R, Martin C, Pocacqua V, Gardner SL, Franceschi A, Bandi C, , 2004. Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution. Int J Parasitol 34: 191203.[Crossref] [Google Scholar]
  24. Casiraghi M, Bazzocchi C, Mortarino M, Ottina E, Genchi C, , 2006. A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris). Vet Parasitol 141: 368372.[Crossref] [Google Scholar]
  25. Tamura K, Dudley J, Nei M, Kumar S, , 2007. Mega4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol Biol Evol 24: 15961599.[Crossref] [Google Scholar]
  26. Eberhard ML, Dickerson JW, Tsang VC, Walker EM, Ottesen EA, Chandrashekar R, Weil GJ, Trips M, Strobert E, Constantinidis I, , 1995. Onchocerca volvulus: parasitologic and serologic responses in experimentally infected chimpanzees and mangabey monkeys. Exp Parasitol 80: 454462.[Crossref] [Google Scholar]
  27. Otranto D, Traversa D, , 2005. Thelazia eyeworm: an original endo- and ecto-parasitic nematode. Trends Parasitol 21: 14.[Crossref] [Google Scholar]
  28. Özkara S, Isiksel S, Kilic G, , 2003. A rare case of filarial infection in Turkey: Onchocerca volvulus infection. Turk J Infect 17: 107109. [Google Scholar]
  29. Uni S, Bain O, Agatsuma T, Harada M, Torii H, Fukuda M, Takaoka H, , 2007. Onchocerca eberhardi n. sp. (Nematoda: Filarioidea) from sika deer in Japan; relationships between species parasitic in cervids and bovids in the Holarctic region. Parasite 14: 199211.[Crossref] [Google Scholar]

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  • Received : 19 Aug 2010
  • Accepted : 13 Oct 2010
  • Published online : 05 Jan 2011

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