Volume 85, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Leishmaniases are a group of vector-borne diseases with different clinical manifestations caused by parasites transmitted by sand fly vectors. In Mexico, the sand fly is the only vector proven to transmit the parasite to humans, which causes leishmaniasis. Other vector species with potential medical importance have been obtained, but their geographic distributions and relation to transmission areas have never been assessed. We modeled the ecological niches of nine sand fly species and projected niches to estimate potential distributions by using known occurrences, environmental coverages, and the algorithms GARP and Maxent. All vector species were distributed in areas with known recurrent transmission, except for , which appeared to be related only to areas of occasional transmission in northern Mexico. The distribution of does not overlap with all reported cutaneous leishmaniasis cases, suggesting that and are likely also involved as primary vectors in those areas. Our study provides useful information of potential risk areas of leishmaniasis transmission in Mexico.


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  1. Mullner RM, Chung K, Croke KG, Mensah EK, , 2004. Geographic information systems in public health and medicine. J Med Syst 28: 215221.[Crossref] [Google Scholar]
  2. Peterson AT, Sánchez-Cordero V, Beard CB, Ramsey JM, , 2002. Ecologic niche modeling and potential reservoirs for Chagas disease, México. Emerg Infect Dis 8: 662667.[Crossref] [Google Scholar]
  3. Peterson AT, Shaw J, , 2003. Lutzomyia vectors for cutaneous leishmaniasis in southern Brazil: ecological niche models, predicted geographic distributions, and climate change effects. Int J Parasitol 33: 919931.[Crossref] [Google Scholar]
  4. Peterson AT, Scachetti R, Fonseca de Camargo V, , 2004. Using epidemiological survey data to infer geographic distributions of leishmaniasis vector species. Rev Soc Bras Med Trop 37: 1014.[Crossref] [Google Scholar]
  5. Peterson AT, Martínez-Campos C, Nakazawa Y, Martínez-Meyer E, , 2005. Time-specific ecological niche modeling predicts spatial dynamics of vector insects and human dengue cases. Trans R Soc Trop Med Hyg 99: 647655.[Crossref] [Google Scholar]
  6. Peterson AT, , 2008. Biogeography of diseases: a framework for analysis. Naturwissenschaften 95: 483491.[Crossref] [Google Scholar]
  7. Grinnell J, , 1917. Field tests of theories concerning distribution control. Am Nat 51: 115128.[Crossref] [Google Scholar]
  8. Velasco-Castrejón O, , 1987. Leishmaniasis in Mexico. Rev Latinoam Microbiol 29: 119126. [Google Scholar]
  9. Travi B, Montoya J, , 1994. CIDEIM. Manual de Entomología Médica para Investigadores de América Latina. Cali, Colombia: Fundación Centro Internacional de Entrenamiento e Investigaciones Médicas Fundación CIDEIM. [Google Scholar]
  10. Rebollar-Téllez E, Reyes-Villanueva F, Fernández-Salas I, Andrade-Narváez FJ, , 1996. Population dynamics and biting rhythm of the anthropophilic sandfly Lutzomyia cruciata in southeast México. Rev Inst Med Trop Sao Paulo 38: 2933.[Crossref] [Google Scholar]
  11. Monroy-Ostria A, Hernandez–Montes O, Barker DC, , 2000. Aetiology of visceral leishmaniasis in Mexico. Acta Trop 75: 155161.[Crossref] [Google Scholar]
  12. Galati BE, , 1995. Phylogenetic systematics of phlebotominae (Diptera: Psychodidae) with emphasis on American groups. Bol Dir Malariol San Amb 35: 133142. [Google Scholar]
  13. Lewis DJ, Young DG, Fairchild GB, Minter DM, , 1977. Proposals for a stable classification of the phlebotomine sandflies (Diptera: Psychodidae). Syst Entomol 2: 319332.[Crossref] [Google Scholar]
  14. Killick-Kendrick R, , 1990. Phlebotomine vectors of the leishmaniases: a review. Med Vet Entomol 4: 124.[Crossref] [Google Scholar]
  15. Killick-Kendrick R, , 1999. The biology and control of phlebotomine sand flies. Clin Dermatol 17: 279289.[Crossref] [Google Scholar]
  16. Biagi FF, De Biagi AM, Beltrán F, , 1965. Phlebotomus flaviscutellatus, transmisor natural de Leishmania mexicana . Prensa Med Mex 30: 276272. [Google Scholar]
  17. Pech-May A, Escobedo-Ortegón FJ, Berzunza-Cruz M, Rebollar-Téllez EA, , 2010. Incrimination of four sandfly species previously unrecognized as vectors of Leishmania parasites in Mexico. Med Vet Entomol 24: 150161.[Crossref] [Google Scholar]
  18. Rebollar-Téllez E, Ramírez-Fraire A, Andrade-Narvaez FJ, , 1996. A two-year study on vectors of cutaneous leishmaniasis: evidence for sylvatic transmission in the state of Campeche, Mexico. Mem Inst Oswaldo Cruz 91: 555560.[Crossref] [Google Scholar]
  19. Disney RH, , 1968. Observations on a zoonosis: leishmaniasis in British Honduras. J Appl Ecol 5: 159.[Crossref] [Google Scholar]
  20. Williams P, , 1966. The biting rhythms of some anthropophilic phlebotomine sandflies in British Honduras. Ann Trop Med Parasitol 60: 357364.[Crossref] [Google Scholar]
  21. Williams P, , 1970. Phlebotomine sandflies and leishmaniasis in British Honduras (Belize). Trans R Soc Trop Med Hyg 64: 317364.[Crossref] [Google Scholar]
  22. Rebollar-Téllez E, Reyes-Villanueva F, Fernández-Salas I, Andrade-Narváez FJ, , 1996. Abundance and parity rate of Lutzomyia cruciata in an endemic focus of localized cutaneous leishmaniasis in southern Mexico. J Med Entomol 33: 683685.[Crossref] [Google Scholar]
  23. Rebollar-Téllez E, Manrique-Saide P, , 2001. New distributional record of Lutzomyia cruciata in the state of Yucatan, Mexico. Entomol News 112: 337339. [Google Scholar]
  24. Porter CH, Steurer FJ, Kreutzer RD, , 1987. Isolation of Leishmania mexicana mexicana from Lutzomyia ylephiletor in Guatemala. Trans R Soc Trop Med Hyg 81: 929930.[Crossref] [Google Scholar]
  25. Miranda A, Carrasco R, Paz H, Pascale JM, Samudio F, Saldaña A, Santamaría G, Mendoza Y, Calzada JE, , 2009. Molecular epidemiology of American tegumentary leishmaniasis in Panama. Am J Trop Med Hyg 81: 565571.[Crossref] [Google Scholar]
  26. Young DG, Duncan MA, , 1994. Guide to the Identification and Geographic Distribution of Lutzomyia Sand Flies in Mexico, The West Indies, Central and South America (Diptera: Psychodidae). Memoirs of the Entomological Institute, No. 54, Gainesville, FL: Associated Publishers. [Google Scholar]
  27. McHugh CP, Grogl M, Kreutzer RD, , 1993. Isolation of Leishmania mexicana (Kinetoplastida: Trypanosomatidae) from Lutzomyia anthophora (Diptera: Psychodidae) collected in Texas. J Med Entomol 30: 631633.[Crossref] [Google Scholar]
  28. McHugh CP, Melby PC, LaFon S, , 1996. Leishmaniasis in Texas: epidemiological and clinical aspects of human cases. Am J Trop Med Hyg 55: 547555. [Google Scholar]
  29. Lawyer PG, Young DG, Butler JF, Akin DE, , 1987. Development of Leishmania mexicana in Lutzomyia diabolica and Lutzomyia shannoni (Diptera: Psychodidae). J Med Entomol 24: 347355.[Crossref] [Google Scholar]
  30. Endris RG, Young DG, Perkins PV, , 1987. Experimental transmission of Leishmania mexicana by a North American sand fly, Lutzomyia anthophora (Diptera: Psychodidae). J Med Entomol 24: 243247.[Crossref] [Google Scholar]
  31. Young DG, Perkins PV, , 1984. Phlebotomine sand flies of North America (Diptera: Psychodidae). Mosq News 44: 263304. [Google Scholar]
  32. Travi BL, Montoya J, Gallego J, Jaramillo C, Llano R, Velez ID, , 1996. Bionomics of Lutzomyia evansi (Diptera: Psychodidae) vector of visceral leishmaniasis in northern Colombia. J Med Entomol 33: 278285.[Crossref] [Google Scholar]
  33. Lainson R, Ward RD, Shaw JJ, , 1977. Experimental transmission of Leishmania chagasi, causative agent of neotropical visceral leishmaniasis, by the sandfly Lutzomyia longipalpis . Nature 266: 628630.[Crossref] [Google Scholar]
  34. Young DG, , 1979. A Review of the Bloodsucking Psychodid Flies of Colombia (Diptera: Phlebotominae and Sycoracinae). Institute of Food and Agricultural Sciences Technical Bulletin 806. Gainesville, FL: University of Florida. [Google Scholar]
  35. Montoya-Lerma J, Ferro C, Amat-G G, Andrade-C G, Fernández F, , 1999. Flebótomos (Diptera: Psychodidae) de Colombia. , eds. Insectos de Colombia. Volume II. Academia Colombiana de Ciencias Exactas, Fisicas y Naturales. Colección Jorge Alvarez Lleras No 13. Santa Fe de Bogotá, Mexico: Editora Guadalupe, 210245. [Google Scholar]
  36. Maingon RD, Ward RD, Hamilton JG, Bauzer LG, Peixoto AA, , 2007. The Lutzomyia longipalpis species complex: does population sub-structure matter to Leishmania transmission? Trends Parasitol 24: 1217.[Crossref] [Google Scholar]
  37. Travi BL, Vélez ID, Brutus L, Segura I, Jaramillo C, Montoya J, , 1990. Lutzomyia evansi, an alternate vector of Leishmania chagasi in a Colombian focus of visceral leishmaniasis. Trans R Soc Trop Med Hyg 84: 676677.[Crossref] [Google Scholar]
  38. Zeledón R, Murillo J, Gutiérrez H, , 1984. Observaciones sobre la ecología de Lutzomyia longipalpis (Lutz & Neiva, 1912) y posibilidades de existencia de leishmaniasis visceral en Costa Rica. Mem Inst Oswaldo Cruz 79: 455459.[Crossref] [Google Scholar]
  39. Montoya-Lerma J, Cadena H, Oviedo M, Ready PD, Barazarte R, Travi BL, Lane RP, , 2003. Comparative vectorial efficiency of Lutzomyia evansi and Lu. longipalpis for transmitting Leishmania chagasi . Acta Trop 85: 1929.[Crossref] [Google Scholar]
  40. Ibáñez-Bernal S, Rodríguez-Domínguez G, Gómez-Dantes CH, Ricardez-Esquinca JR, , 2004. First record of Lutzomyia evansi (Nuñez-Tovar 1924) in Mexico (Diptera: Psychodidae, Phlebotominae). Mem Inst Oswaldo Cruz 99: 127129.[Crossref] [Google Scholar]
  41. Seidelin H, , 1912. Leishmaniasis and babesiasis in Yucatán. Ann Trop Med Parasitol 6: 295299.[Crossref] [Google Scholar]
  42. Beltrán E, Bustamante ME, , 1942. Datos epidemiológicos acerca de la úlcera de los chicleros (Leishmania americana) en México. Rev Inst Salubr Enferm Trop 3: 128. [Google Scholar]
  43. Beltrán E, , 1944. Cutaneous leishmaniasis in Mexico. Sci Mon 59: 108119. [Google Scholar]
  44. Rebollar-Téllez EA, Tun-Ku E, Manrique-Saide PC, Andrade-Narvaez FJ, , 2005. Relative abundances of sand fly species (Diptera: Phlebotominae) in two villages in the same area of Campeche, in southern Mexico. Ann Trop Med Parasitol 99: 193201.[Crossref] [Google Scholar]
  45. Rowton E, de Mata M, Rizzo N, Navin T, Porter C, , 1991. Vectors of Leishmania braziliensis in the Petén, Guatemala. Parasitologia 33: 501504. [Google Scholar]
  46. Feliciangeli MD, Reyes RM, Limongi JE, , 1988. Natural infection of Lutzomyia ovallesi (Diptera: Psychodidae) with parasites of the Leishmania braziliensis complex in a restricted focus of cutaneous leishmaniasis in northern Venezuela. Mem Inst Oswaldo Cruz 83: 393394.[Crossref] [Google Scholar]
  47. Bonfante-Garrido R, Spinetti H, Cupillo E, Momen H, Grimaldi G, , 1991. Lutzomyia ovallesi (Diptera: Psychodidae) as a vector of cutaneous leishmaniasis in Venezuela. Parasitologia 33: 99104. [Google Scholar]
  48. Christensen HA, Fairchild GB, Herrer A, Johnson CM, Young DG, de Vázquez AM, , 1983. The ecology of cutaneous leishmaniasis in the Republic of Panama. J Med Entomol 20: 463484.[Crossref] [Google Scholar]
  49. Ibáñez-Bernal S, , 1999. Phlebotominae (Diptera: Psychodidae) de México. I. Brumptomyia França y Parrot; Lutzomyia França, las especies de L. (Lutzomyia) Fança y del grupo Verrucarum . Folia Entomol Mex 107: 61118. [Google Scholar]
  50. Ibáñez-Bernal S, , 2001. Phlebotominae (Diptera: Psychodidae) de México. II. Las especies de Lutzomyia (Coromyia) Barretto, del grupo Delpozoi y de Lutzomyia (Dampfomyia) Addis. Folia Entomol Mex 40: 1746. [Google Scholar]
  51. Ibáñez-Bernal S, , 2002. Phlebotominae (Diptera: Psychodidae) de México. III. Las especies de Lutzomyia (Psathyromyia) Barretto, del grupo Aragoi, de L. (Trichopygomyia) Barreto, del grupo Dreisbachi y de L. (Nyssomyia) Barretto. Folia Entomol Mex 41: 149183. [Google Scholar]
  52. Ibáñez-Bernal S, , 2003. Phlebotominae (Diptera: Psychodidae) de México. IV. Las especies de Lutzomyia (Psychodopygus) Mangabeira, L. (Micropygomyia) Barretto, Lutzomyia del grupo Oswaldoi, L. (Helcocyrthomyia) Barretto, y especies del género sin agrupar. Folia Entomol Mex 42: 109152. [Google Scholar]
  53. Van Wynsberghe NR, Canto-Lara SB, Sosa-Bibiano EI, Rivero-Cárdenas NA, Andrade-Narváez FJ, , 2009. Comparison of small mammal prevalence of Leishmania (Leishmania) mexicana in five foci of cutaneous leishmaniasis in the state of Campeche, Mexico. Rev Inst Med Trop Sao Paulo 51: 8794.[Crossref] [Google Scholar]
  54. Godinez-Alvarez A, Ibáñez-Bernal S, , 2010. Catálogo de Psychodidae (Diptera) de la colección de artrópodos con importancia médica del InDRE, Secretaria de Salud, Mexico. Acta Zool Mex 26: 99121. [Google Scholar]
  55. Comisión Nacional para el Conocimiento y Uso de la Biodiversidad, 2004. Cabeceras Municipales, 2000. Extraído de Principales Resultados por Localidad. XII Censo de Población y Vivienda 2000 del Instituto Nacional de Estadística Geografía e Informática (INEGI). Mexico City: Comisión Nacional para el Conocimiento y Uso de la Biodiversidad. [Google Scholar]
  56. Stockwell DR, Peters D, , 1999. The GARP modeling system: problems and solutions to automated spatial prediction. Int J Geogr Inf Sci 13: 143158.[Crossref] [Google Scholar]
  57. Phillips SJ, Anderson RP, Schapire RE, , 2006. Maximum entropy modeling of species geographic distributions. Ecol Modell 190: 231259.[Crossref] [Google Scholar]
  58. Elith J, Graham CH, Anderson RP, Dudik M, Ferrier S, Guisan A, Hijmans RJ, Huettman F, Leathwick JR, Lehmann A, Li J, Lohmann LG, Loiselle BA, Manion G, Moritz C, Nakamura M, Nakazawa Y, Overton JM, Peterson AT, Phillips SJ, Richardson K, Scachetti-Pereira R, Schapire RE, Soberón J, Williams SE, Wisz MS, Zimmermann NE, , 2006. Novel methods to improve prediction of species' distributions from occurrence data. Ecography 29: 129151.[Crossref] [Google Scholar]
  59. Peterson AT, Papes M, Eaton M, , 2007. Transferability and model evaluation in ecological niche modeling: comparison of GARP and Maxent. Ecography 30: 550560.[Crossref] [Google Scholar]
  60. Graham CH, Elith J, Hijmans R, Guisan A, Peterson AT, Loiselle BA, , NCEAS Species Distribution Modeling Group, 2007. The influence of spatial errors in species occurrence data used in distribution models. J Appl Ecol 45: 239247.[Crossref] [Google Scholar]
  61. Araujo MB, New M, , 2007. Ensemble forecasting of species distributions. Trends Ecol Evol 22: 4247.[Crossref] [Google Scholar]
  62. Anderson RP, Lew D, Peterson AT, , 2003. Evaluating predictive models of species' distributions: criteria for selecting optimal models. Ecol Modell 162: 211232.[Crossref] [Google Scholar]
  63. Raxworthy CJ, Martinez-Meyer E, Horning N, Nussbaum RA, Schneider GE, Ortega-Huerta MA, Peterson AT, , 2003. Predicting distributions of known and unknown reptile species in Madagascar. Nature 426: 837841.[Crossref] [Google Scholar]
  64. Hijmans RJ, Cameron SE, Parra JL, Jones PG, Jarvis A, , 2005. Very high resolution interpolated climate surfaces for global land areas. Int J Climatol 25: 19651978.[Crossref] [Google Scholar]
  65. Hijmans RJ, Cameron S, Parra J, , 2005. WorldClim, Versión 1.3. Available at: http://biogeo.berkeley.edu/worldclim/worldclim.htm. [Google Scholar]
  66. U.S. Geological Survey, 2001. HYDRO 1k Elevation Derivative Database. Washington, DC: U.S. Geological Survey. Available at: http://edcdaac.usgs.gov/gtopo30/hydro/. [Google Scholar]
  67. Olson DM, Dinerstein E, Wikramanayake ED, Burgess ND, Powell GV, Underwood EC, D'Amico JA, Itoua I, Strand HE, Morrison JC, Loucks CJ, Allnutt TF, Ricketts TH, Kura Y, Lamoreux JF, Wettengel WW, Hedao P, Kassem KR, , 2001. Terrestrial ecoregions of the world: a new map of life on earth. Biocience 51: 933938.[Crossref] [Google Scholar]
  68. World Health Organization, 1990. Control of the leishmaniases. Report of a WHO expert committee. World Health Organ Tech Rep Ser 793: 1158. [Google Scholar]
  69. Sánchez-García L, Berzunza-Cruz M, Becker-Fauser I, Rebollar-Téllez EA, , 2010. Sand flies naturally infected by Leishmania mexicana in the peri-urban area of Chetumal city, Quintana Roo, México. Trans R Soc Trop Med Hyg 104: 406411.[Crossref] [Google Scholar]
  70. Minter L, Kovacic B, Claborn DM, Lawyer P, Florin D, Brown GC, , 2009. New state records for Lutzomyia shannoni and Lutzomyia vexator . J Med Entomol 46: 965968.[Crossref] [Google Scholar]
  71. McHugh CP, Grogl M, Kerr SF, , 1990. Isolation of Leishmania mexicana from Neotoma micropus collected in Texas. J Parasitol 76: 741742.[Crossref] [Google Scholar]
  72. Kerr SF, McHugh CP, Merkelz R, , 1999. A focus of Leishmania mexicana near Tucson, Arizona. Am J Trop Med Hyg 61: 378379. [Google Scholar]
  73. Chablé-Santos JB, Van Wynsberghe NR, Canto-Lara SB, Andrade-Narvaez FJ, , 1995. Isolation of Leishmania (L.) mexicana from wild rodents and their possible role in the transmission of localized cutaneous leishmaniasis in the state of Campeche, Mexico. Am J Trop Med Hyg 53: 141145. [Google Scholar]
  74. Van Wynsberghe NR, Canto-Lara SB, Damián-Centeno AG, Itzá-Ortiz MF, Andrade-Narváez FJ, , 2000. Retention of Leishmania (Leishmania) mexicana in naturally infected rodents from the state of Campeche, Mexico. Mem Inst Oswaldo Cruz 95: 595600.[Crossref] [Google Scholar]
  75. Sánchez-Tejeda G, Rodríguez N, Parra CI, Hernández-Montes O, Barker DC, Monroy-Ostria A, , 2001. Cutaneous leishmaniasis caused by members of Leishmania braziliensis complex in the state of Nayarit, Mexico. Mem Inst Oswaldo Cruz 96: 1519.[Crossref] [Google Scholar]
  76. Rebollar-Téllez EA, Orilla-Moguel H, Dzul-Manzanilla F, Che-Mendoza A, Manrique-Saide P, Zapata-Peniche A, , 2006. An update on the phlebotomid sandfly fauna from Yucatan, Mexico. Entomol News 117: 2124.[Crossref] [Google Scholar]
  77. Berzunza-Cruz M, Bricaire G, Zuloaga Romero S, Pérez-Becker R, Saavedra-Lira E, Pérez-Montfort R, Crippa-Rossi M, Velasco-Castrejón O, Becker I, , 2000. Leishmania mexicana mexicana: genetic heterogeneity of Mexican isolates revealed by restriction length polymorphism analysis of kinetoplast DNA. Exp Parasitol 95: 277284.[Crossref] [Google Scholar]
  78. Pérez-Vega J, López-Moreno C, López-Valenzuela J, Rendón-Maldonado J, López-Moreno H, , 2009. Cutaneous leishmaniasis caused by Leishmania mexicana in Durango, Mexico: first clinical case report. Gac Med Mex 145: 433435. [Google Scholar]
  79. González C, Wang O, Strutz SE, González-Salazar C, Sánchez-Cordero V, Sarkar S, , 2010. Climate change and risk of leishmaniasis in North America: predictions from ecological niche models of vector and reservoir species. PLoS Negl Trop Dis 4: e585.[Crossref] [Google Scholar]
  80. Andrade Barata R, França-Silva JC, Mayrink W, Costa da Silva J, Prata A, Seixas Lorosa E, Araújo Fiúza J, Macedo Gonçalves C, de Paula MK, Santos Dias E, , 2005. Aspectos da ecologia e do comportamento de flebotomíneos em área endêmica de leishmaniose visceral, Minas Gerais. Rev Soc Bras Med Trop 38: 421425.[Crossref] [Google Scholar]
  81. Salomón OD, Quintana MG, Bruno MR, Quiriconi RV, Cabral V, , 2009. Visceral leishmaniasis in border areas: clustered distribution of phlebotomine sand flies in Clorinda, Argentina. Mem Inst Oswaldo Cruz 104: 801804.[Crossref] [Google Scholar]

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  • Received : 12 Aug 2010
  • Accepted : 28 Feb 2011
  • Published online : 01 Nov 2011

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