Volume 85, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We reviewed the records of 446 patients who were treated surgically for cystic echinococcosis (CE) to identify risk factors for anaphylactic shock. Of 446 patients, 10 had final diagnoses of anaphylactic shock induced by CE; none died. The incidence of anaphylactic shock was significantly higher in younger age groups ( < 0.001) and in patients with pulmonary cysts. Anaphylactic shock induced by CE appears to differ from type I immediate hypersensitivity shock, which suggests that in CE, shock may be caused by a combination of immediate hypersensitivity and endotoxic shock. This possibility suggests that additional precautions should be taken during surgery. These precautions include reducing intracystic pressure, which would prevent possible leaked liquid from reaching other organs by surrounding the cyst with sterile gauze and decrease the chance of spreading the echinococcus; preventing antigen from contacting other tissues where it might trigger anaphylaxis; and resecting the cyst completely when feasible.


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  1. WHO/OIE Eckert J, Gemmell MA, Meslin FX, Pawlowski ZS, , 2001. Manual on Echinococcosis in Humans and Animals. , eds. Paris: Office International des Epizooties.
  2. Vuitton DA, , 2004. Echinococcosis and allergy. Clin Rev Allergy Immunol 26: 93104.[Crossref]
  3. Dunn PF, , ed, 2007. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 7th Edition. Philadelphia: Lippincott Williams and Wilkins, 1.
  4. Sampson HA, Muñoz-Furlong A, Bock SA, Schmitt C, Bass R, Chowdhury BA, Decker WW, Furlong TJ, Galli SJ, Golden DB, Gruchalla RS, Harlor AD, Jr Hepner DL, Howarth M, Kaplan AP, Levy JH, Lewis LM, Lieberman PL, Metcalfe DD, Murphy R, Pollart SM, Pumphrey RS, Rosenwasser LJ, Simons FE, Wood JP, Camargo CA, Jr, 2005. Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol 115: 584591.[Crossref]
  5. Feng X, Wen H, Zhang Z, Chen X, Ma X, Zhang J, Qi X, Bradshaw H, Vuitton D, Craig PS, , 2010. Dot immunogold filtration assay (DIGFA) with multiple native antigens for rapid serodiagnosis of human cystic and alveolar echinococcosis. Acta Trop 113: 114120.[Crossref]
  6. Brunetti E, Kern P, Vuitton DA, , Writing Panel for the WHO-IWGE, 2010. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 114: 116.[Crossref]
  7. Sullivan TJ, Lichtenstein LM, Fauci AS, , 1988. Systemic anaphylaxis. , eds. Current Therapy in Allergy, Immunology, and Rheumatology. Third edition. Toronto, Canada: B. C. Decker, 9198.
  8. Alves B, Sheikh A, , 2001. Age specific aetiology of anaphylaxis. Arch Dis Child 85: 348.[Crossref]
  9. Sheikh A, Alves B, , 2001. Age, sex, geographical and socio-economic variations in admissions for anaphylaxis: analysis of four years of English hospital data. Clin Exp Allergy 31: 15711576.[Crossref]
  10. Brown SG, , 2004. Clinical features and severity grading of anaphylaxis. J Allergy Clin Immunol 114: 371376.[Crossref]
  11. Felix SB, Baumann G, Berdel WE, , 1990. Systemic anaphylaxis: separation of cardiac reactions from respiratory and peripheral vascular events. Res Exp Med (Berl) 190: 239252.[Crossref]
  12. Riganò R, Profumo E, Bruschi F, Carulli G, Azzarà A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A, , 2001. Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses. Infect Immun 69: 288296.[Crossref]
  13. Miyajima I, Dombrowicz D, Martin TR, Ravetch JV, Kinet JP, Galli SJ, , 1997. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest 99: 901914.[Crossref]
  14. Yamashita N, Tajima M, Nakano J, Arioka H, Arai H, Miyasaka T, Kubota S, Kawashima R, Ohta K, , 2000. Induction of apoptosis in bronchial eosinophils: beneficial or harmful? Int Arch Allergy Immunol 122 (Suppl 1): 4043.[Crossref]

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  • Received : 11 Aug 2010
  • Accepted : 01 Jun 2011

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