1921
Volume 84, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We used a species-specific approach to treat 10 patients with cutaneous leishmaniasis diagnosed using polymerase chain reaction. Non-antimony treatments (oral miltefosine, ketoconazole, and liposomal amphotericin B) were chosen as an alternative to pentavalent antimony drugs based on likely or proven drug efficacy against the infecting species. was diagnosed in three patients and treated successfully with oral ketoconazole. Miltefosine treatment cured two patients with . A wide variety of responded to liposomal amphotericin B administered for 5–7 days. Three patients with , one patient with , and two patients with were treated successfully. One person with healed slowly because of a resistant bacterial superinfection, and a second patient with relapsed and was retreated with miltefosine. These drugs were reasonably well-tolerated. In this limited case series, alternative non-antimony–based regimens were convenient, safe, and effective.

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  • Received : 04 Aug 2010
  • Accepted : 27 Oct 2010

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