Volume 84, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



, a paralog of the candidate vaccine antigen merozoite surface protein 1, possesses a signal peptide at its N-terminus and two epidermal growth factor–like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The gene locus may have originated by a duplication of the gene locus in a common ancestor of the analyzed species and lost from , , and during their evolutionary history. Full-length sequences of the gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1–A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.


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  • Received : 30 Jul 2010
  • Accepted : 07 Oct 2010
  • Published online : 04 Feb 2011

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