Volume 84, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The efficiency of malaria prevention during pregnancy was compared between three studies in Benin for malaria infection of the placenta (MIP) and low birth weight (LBW). The first was carried out when chloroquine prophylaxis was still recommended, the second was an intermittent preventive treatment in pregnancy (IPTp) clinical trial comparing sulfadoxine pyrimetamine (SP) versus mefloquine, and the third was an observational study after SP-IPTp national implementation. We showed an association between the use of IPTp and the reduction of LBW (10% with national IPTp and 8.7% in IPTp trial versus 15.7% in pre-trial study). The effect on MIP was better in the trial (2.9% versus 11.2% and 16.7% for national IPTp and pre-trial studies, respectively). In spite of a good overall compliance with the national IPTp (with 84% of women taking at least one dose of SP), there are still failures in adherence to the directly observed therapy (DOT) scheme and needs for better training of health staff.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the Africa Region. Geneva, Switzerland: World Health Organization. [Google Scholar]
  2. Steketee RW, Nahlen BL, Parise ME, Menendez C, , 2001. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg 64: 2835. [Google Scholar]
  3. Steketee RW, Wirima JJ, Hightower AW, Slutsker L, Heymann DL, Breman JG, , 1996. The effect of malaria and malaria prevention in pregnancy on offspring birthweight, prematurity, and intrauterine growth retardation in rural Malawi. Am J Trop Med Hyg 55: 3341. [Google Scholar]
  4. McCormick MC, , 1985. The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 312: 8290.[Crossref] [Google Scholar]
  5. Denoeud L, Fievet N, Aubouy A, Ayemonna P, Kiniffo R, Massougbodji A, Cot M, , 2007. Is chloroquine chemoprophylaxis still effective to prevent low birth weight? Results of a study in Benin. Malar J 6: 27.[Crossref] [Google Scholar]
  6. Briand V, Cottrell G, Massougbodji A, Cot M, , 2007. Intermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas. Malar J 6: 160.[Crossref] [Google Scholar]
  7. Briand V, Denoeud L, Massougbodji A, Cot M, , 2008. Efficacy of intermittent preventive treatment versus chloroquine prophylaxis to prevent malaria during pregnancy in Benin. J Infect Dis 198: 594601.[Crossref] [Google Scholar]
  8. Le Port A, Cottrell G, Dechavanne C, Pierrat C, Bouraima A, Massougbodgi A, Chandre F, Martin-Prevel Y, Migot-Nabias F, Cot M, Garcia A, , 2010. First malaria infections among infants in Benin: biological, environmental and genetic determinants. Description of the study site, general methodology and study population. (submitted). [Google Scholar]
  9. Briand V, Bottero J, Noel H, Masse V, Cordel H, Guerra J, Kossou H, Fayomi B, Ayemonna P, Fievet N, Massougbodji A, Cot M, , 2009. Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. J Infect Dis 200: 9911001.[Crossref] [Google Scholar]
  10. Institut National de la Statistique et de l'Analyse Économique (INSAE), 2007. Demographic and Health Survey (DHS) Benin, 2006. Final Report. Available at: http://www.measuredhs.com/pubs/pub_details.cfm?ID=733. Accessed October 15, 2010. [Google Scholar]
  11. Aubouy A, Fievet N, Bertin G, Sagbo JC, Kossou H, Kinde-Gazard D, Kiniffo R, Massougbodji A, Deloron P, , 2007. Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin. Trop Med Int Health 12: 886894.[Crossref] [Google Scholar]
  12. Ramharter M, Schuster K, Bouyou-Akotet MK, Adegnika AA, Schmits K, Mombo-Ngoma G, Agnandji ST, Nemeth J, Afene SN, Issifou S, Onnas IN, Kombila M, Kremsner PG, , 2007. Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon. Am J Trop Med Hyg 77: 418422. [Google Scholar]
  13. Roll Back Malaria, 2000. The African Summit on Roll Back Malaria. Abudja, Nigeria: World Health Organization. [Google Scholar]
  14. Hill J, Kazembe P, , 2006. Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges. Trop Med Int Health 11: 409418.[Crossref] [Google Scholar]
  15. Crawley J, Hill J, Yartey J, Robalo M, Serufilira A, Ba-Nguz A, Roman E, Palmer A, Asamoa K, Steketee R, , 2007. From evidence to action? Challenges to policy change and programme delivery for malaria in pregnancy. Lancet Infect Dis 7: 145155.[Crossref] [Google Scholar]
  16. Mbonye AK, Schultz Hansen K, Bygbjerg IC, Magnussen P, , 2008. Effect of a community-based delivery of intermittent preventive treatment of malaria in pregnancy on treatment seeking for malaria at health units in Uganda. Public Health 122: 516525.[Crossref] [Google Scholar]
  17. Brabin L, Stokes E, Dumbaya I, Owens S, , 2009. Rural Gambian women's reliance on health workers to deliver sulphadoxine-pyrimethamine as recommended intermittent preventive treatment for malaria in pregnancy. Malar J 8: 25.[Crossref] [Google Scholar]
  18. Mubyazi GM, Bloch P, Magnussen P, Olsen OE, Byskov J, Hansen KS, Bygbjerg IC, , 2010. Women's experiences and views about costs of seeking malaria chemoprevention and other antenatal services: a qualitative study from two districts in rural Tanzania. Malar J 9: 54.[Crossref] [Google Scholar]
  19. Sirima SB, Cotte AH, Konate A, Moran AC, Asamoa K, Bougouma EC, Diarra A, Ouedraogo A, Parise ME, Newman RD, , 2006. Malaria prevention during pregnancy: assessing the disease burden one year after implementing a program of intermittent preventive treatment in Koupela District, Burkina Faso. Am J Trop Med Hyg 75: 205211. [Google Scholar]
  20. Akinleye SO, Falade CO, Ajayi IO, , 2009. Knowledge and utilization of intermittent preventive treatment for malaria among pregnant women attending antenatal clinics in primary health care centers in rural southwest, Nigeria: a cross-sectional study. BMC Pregnancy Childbirth 9: 28.[Crossref] [Google Scholar]
  21. Brabin BJ, Warsame M, Uddenfeldt-Wort U, Dellicour S, Hill J, Gies S, , 2008. Monitoring and evaluation of malaria in pregnancy—developing a rational basis for control. Malar J 7 (Suppl 1): S6.[Crossref] [Google Scholar]
  22. ter Kuile FO, van Eijk AM, Filler SJ, , 2007. Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. JAMA 297: 26032616.[Crossref] [Google Scholar]
  23. World Health Organization, 2002. Monitoring Antimalarial Drug Resistance. Report of WHO consultation. Geneva, Switzerland: World Health Organization. [Google Scholar]
  24. Roll Back Malaria, , 2005. Global Strategic Plan 2005–2015. Geneva, Switzerland: World Health Organization. [Google Scholar]

Data & Media loading...

  • Received : 03 Jun 2010
  • Accepted : 10 Sep 2010
  • Published online : 04 Feb 2011

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error