1921
Volume 84, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We report the first case of visceral leishmaniasis (VL) from the non-endemic western hilly region of Nepal. The patient presented with a history of high-grade fever, abdominal distension, anemia, and weight loss. The case was confirmed as VL by microscopical detection of the species amastigote in bone marrow aspiration and by a positive result for the rK39 test. The patient was treated with 0.5–1.0 mg/kg of Amphotericin B for 14 days (total of 405 mg), and amastigotes were negative on discharge. Five months later, this patient again developed fever, abdominal distension, and anemia. Clinical and hematological examinations suggested a relapse of VL. The patient was treated with 1 mg/kg of Amphotericin B for 18 days (total of 515 mg) and was clinically improved on discharge.

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2011-01-05
2017-11-24
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References

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  7. Verma SK, Ahmed S, Shirazi N, Kusum A, Kaushik RM, Barthwal SP, , 2007. Sodium stibogluconate-sensitive visceral leishmaniasis in the non-endemic hilly region of Uttarkhand, India. Trans R Soc Trop Med Hyg 101: 730732.[Crossref]
  8. Mahajan SK, Machhan P, Kanga A, Thakur S, Sharma A, Prasher BS, Pal LS, , 2004. Kala-azar at high altitude. J Commun Dis 36: 117120.
  9. Pandey BD, Pandey K, Kaneko O, Yanagi T, Hirayama K, , 2009. Relapse of visceral leishmaniasis after miltefosine treatment in a Nepalese patient. Am J Trop Med Hyg 80: 580582.
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  • Received : 21 May 2010
  • Accepted : 05 Sep 2010

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