Volume 84, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of ) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.


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  • Received : 19 May 2010
  • Accepted : 25 Jan 2011
  • Published online : 05 Apr 2011

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