1921
Volume 84, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We investigated the type and strength of the immune response to schistosome antigens in a group of 20 Dutch travelers who had been infected with spp. during a group visit to Mali in 1991 and 8 non-infected controls. At the time, 9 had Katayama syndrome (KS), and 11 remained asymptomatic. All had been treated with praziquantel. Eight years later, serology remained positive in all 20 formerly infected travelers. The lymphocyte proliferative responses and cytokine responses (interleukin 13 [IL-13], IL-10, and interferon [IFN-γ] responses to soluble egg antigens and the IL-13, IL-10, and IL-5 response to adult worm antigen) were stronger in the travelers than in the controls and tended to be stronger in those with KS compared with those who had remained asymptomatic. In conclusion, infection induced a memory immune response, and people who experienced KS tended to have a stronger immune response to schistosome antigens than their asymptomatic counterparts.

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2011-01-05
2017-09-22
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References

  1. Souza SS, de Souza Neto JP, Andrade ZA, , 2009. Pulmonary changes during acute experimental murine manson schistosomiasis. Rev Soc Bras Med Trop 42: 58.[Crossref]
  2. Herbert DR, Orekov T, Perkins C, Finkelman FD, , 2008. IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis. J Immunol 181: 72147220.[Crossref]
  3. Grzych JM, Pearce E, Cheever A, Caulada ZA, Caspar P, Heiny S, Lewis F, Sher A, , 1991. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol 146: 13221327.
  4. Pearce EJ, , 2005. Priming of the immune response by schistosome eggs. Parasite Immunol 27: 265270.[Crossref]
  5. Fallon PG, Smith P, Dunne DW, , 1998. Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acute Schistosoma mansoni infection. Eur J Immunol 28: 14081416.[Crossref]
  6. Fallon PG, , 2000. Immunopathology of schistosomiasis: a cautionary tale of mice and men. Immunol Today 21: 2935.[Crossref]
  7. Wynn TA, Thompson RW, Cheever AW, Mentink-Kane MM, , 2004. Immunopathogenesis of schistosomiasis. Immunol Rev 201: 156167.[Crossref]
  8. Pearce EJ, MacDonald AS, , 2002. The immunobiology of schistosomiasis. Nat Rev Immunol 2: 499511.[Crossref]
  9. Eloi-Santos SM, Novato-Silva E, Maselli VM, Gazzinelli G, Colley DG, Correa-Oliveira R, , 1989. Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease. J Clin Invest 84: 10281031.[Crossref]
  10. Novato-Silva E, Gazzinelli G, Colley DG, , 1992. Immune responses during human schistosomiasis mansoni. XVIII. Immunologic status of pregnant women and their neonates. Scand J Immunol 35: 429437.[Crossref]
  11. Malhotra I, Ouma J, Wamachi A, Kioko J, Mungai P, Omollo A, Elson L, Koech D, Kazura JW, King CL, , 1997. In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults. J Clin Invest 99: 17591766.[Crossref]
  12. King CL, Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, Kazura JW, , 1998. B cell sensitization to helminthic infection develops in utero in humans. J Immunol 160: 35783584.
  13. Caldas IR, Campi-Azevedo AC, Oliveira LF, Silveira AM, Oliveira RC, Gazzinelli G, , 2008. Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infection. Acta Trop 108: 109117.[Crossref]
  14. de Jesus AR, Silva A, Santana LB, Magalhaes A, de Jesus AA, de Almeida RP, Rego MA, Burattini MN, Pearce EJ, Carvalho EM, , 2002. Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. J Infect Dis 185: 98105.[Crossref]
  15. Williams ME, Montenegro S, Domingues AL, Wynn TA, Teixeira K, Mahanty S, Coutinho A, Sher A, , 1994. Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. J Infect Dis 170: 946954.[Crossref]
  16. Morais CN, Souza JR, Melo WG, Aroucha ML, Miranda P, Domingues AL, Abath FG, Montenegro SM, , 2008. Cytokine profile associated with chronic and acute human schistosomiasis mansoni. Mem Inst Oswaldo Cruz 103: 561568.[Crossref]
  17. Visser LG, Polderman AM, Stuiver PC, , 1995. Outbreak of schistosomiasis among travelers returning from Mali, West Africa. Clin Infect Dis 20: 280285.[Crossref]
  18. Colebunders R, Verstraeten T, Van GA, Van den Ende J, De Roo A, Polderman A, Visser L, , 1995. Acute schistosomiasis in travelers returning from Mali. J Travel Med 2: 235238.[Crossref]
  19. Hiatt RA, Sotomayor ZR, Sanchez G, Zambrana M, Knight WB, , 1979. Factors in the pathogenesis of acute schistosomiasis mansoni. J Infect Dis 139: 659666.[Crossref]
  20. van Lieshout L, Polderman AM, Visser LG, Verwey JJ, Deelder AM, , 1997. Detection of the circulating antigens CAA and CCA in a group of Dutch travelers with acute schistosomiasis. Trop Med Int Health 2: 551557.[Crossref]
  21. Ross AG, Vickers D, Olds GR, Shah SM, McManus DP, , 2007. Katayama syndrome. Lancet Infect Dis 7: 218224.[Crossref]
  22. Visser PS, Pitchford RJ, , 1972. A simple apparatus for rapid recovery of helminth eggs from excreta with special reference to Schistosoma mansoni . S Afr Med J 46: 13441346.
  23. Nash TE, Ottesen EA, Cheever AW, , 1978. Antibody response to a polysaccharide antigen present in the schistosome gut. II. Modulation of antibody response. Am J Trop Med Hyg 27: 944950.
  24. Deelder AM, Kornelis D, , 1981. Immunodiagnosis of recently acquired Schistosoma mansoni infection. A comparison of various immunological techniques. Trop Geogr Med 33: 3641.
  25. Rabello AL, Garcia MM, Pinto da Silva RA, Rocha RS, Katz N, , 1997. Humoral immune responses in patients with acute Schistosoma mansoni infection who were followed up for two years after treatment. Clin Infect Dis 24: 304308.[Crossref]
  26. Whitty CJ, Mabey DC, Armstrong M, Wright SG, Chiodini PL, , 2000. Presentation and outcome of 1107 cases of schistosomiasis from Africa diagnosed in a non-endemic country. Trans R Soc Trop Med Hyg 94: 531534.[Crossref]
  27. Harris AR, Russell RJ, Charters AD, , 1984. A review of schistosomiasis in immigrants in Western Australia, demonstrating the unusual longevity of Schistosoma mansoni . Trans R Soc Trop Med Hyg 78: 385388.[Crossref]
  28. Van der Kleij D, Van Remoortere A, Schuitemaker JH, Kapsenberg ML, Deelder AM, Tielens AG, Hokke CH, Yazdanbakhsh M, , 2002. Triggering of innate immune responses by schistosome egg glycolipids and their carbohydrate epitope GalNAc beta 1-4(Fuc alpha 1-2Fuc alpha 1-3)GlcNAc. J Infect Dis 185: 531539.[Crossref]
  29. Lauzon NM, Mian F, MacKenzie R, Ashkar AA, , 2006. The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity. Cell Immunol 241: 102112.[Crossref]
  30. Dessein A, Kouriba B, Eboumbou C, Dessein H, Argiro L, Marquet S, Elwali NE, Rodrigues V, Li Y, Doumbo O, Chevillard C, , 2004. Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. Immunol Rev 201: 180190.[Crossref]
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  • Received : 06 May 2010
  • Accepted : 07 Oct 2010

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