Volume 84, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



African tick-bite fever is an emerging infectious disease caused by the spotted fever group , and is transmitted by ticks of the genus To determine the seroprevalence of exposure to and risk factors associated with infection, we conducted a cross-sectional study of persons in seven rural villages in distinct ecological habitats of Cameroon. We examined 903 plasma samples by using an indirect immunofluorescence assay for antibodies to and analyzed demographic and occupational data collected from questionnaires. Of the 903 persons tested, 243 (26.9%) had IgG/IgM/IgA reactive with . Persons from four of the seven village sites were significantly more likely to be seropositive ( < 0.05), and lowland forest sites tended to have higher seroprevalences. These results suggest that African tick-bite fever is common in adults in rural areas of Cameroon and that ecological factors may play a role in the acquisition of infection.


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  • Received : 31 Mar 2010
  • Accepted : 14 Oct 2010
  • Published online : 05 Apr 2011

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