1921
Volume 85, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

In the face of recent increase of malaria in central China, we conducted a study to evaluate susceptibility of temperate-zone parasites to antimalarial drugs. During 2005–2006, drug susceptibility was measured for 42 clinical isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (ICs) and 95% confidence intervals (CIs) were 10.87 (4.50–26.26) ng/mL for chloroquine, 4.21 (1.88–9.42–8) ng/mL for mefloquine, 11.82 (6.20–22.56) ng/mL for quinine, 0.13 (0.09–0.20) ng/mL for artesunate, 18.32 (8.08–41.50) ng/mL for pyrimethamine, and 17.73 (10.29–30.57) ng/mL for piperaquine. The IC for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against malaria in central China. The results further indicated that temperate-zone isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand.

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  • Received : 01 Feb 2010
  • Accepted : 02 Apr 2011

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