1921
Volume 84, Issue 2_Suppl
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A non-human primate model for the induction of protective immunity against the pre-erythrocytic stages of malaria using radiation-attenuated sporozoites may help to characterize protective immune mechanisms and identify novel malaria vaccine candidates. Immune responses and protective efficacy induced by vaccination with irradiated sporozoites were evaluated in malaria-naive monkeys. Three groups of six monkeys received two, five, or ten intravenous inoculations, respectively, of 100,000 irradiated sporozoites; control groups received either 10 doses of uninfected salivary gland extract or no inoculations. Immunization resulted in the production low levels of antibodies that specifically recognized sporozoites and the circumsporozoite protein. Additionally, immunization induced low levels of antigen-specific IFN-γ responses. Intravenous challenge with viable sporozoites resulted in partial protection in a dose-dependent manner. These findings suggest that the monkey model may be able to play a role in preclinical development of pre-erythrocytic stage vaccines.

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2017-09-23
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  • Received : 14 Dec 2009
  • Accepted : 15 Mar 2010

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