1921
Volume 83, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The 200-kD merozoite surface protein of (PvMSP-1) is one of the leading vaccine candidates against malaria. However, the gene encoding PvMSP-1 () is highly polymorphic and is a major obstacle to effective vaccine development. To further understand polymorphism in , we obtained 30 full-length sequences from southeastern Turkey. Comparative analysis of sequences from Turkey and other areas showed substantially limited polymorphism. Substitutions were found at 280 and 162 amino acid sites in samples from other regions and those from Turkey, respectively. Eight substitutions were unique to Turkey. In one of them, D/E at position 1706 in the C-terminal 19-kD region, the K/E change at 1709 was the only polymorphism previously known. Limited diversity was also observed in microsatellites. Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.

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2010-12-06
2017-09-25
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References

  1. Collier R, , 2010. WHO reports progress in malaria control. Can Med Assoc J 182: E105E106.[Crossref]
  2. Mendis K, Sina BJ, Marchesini P, Carter R, , 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64: 97106.
  3. Baird JK, , 2007. Neglect of Plasmodium vivax malaria. Trends Parasitol 23: 533539.[Crossref]
  4. Herrera S, Corradin G, Arevalo-Herrera M, , 2007. An update on the search for a Plasmodium vivax vaccine. Trends Parasitol 23: 122128.[Crossref]
  5. Holder AA, Guevara Patino JA, Uthaipibull C, Syed SE, Ling IT, Scott-Finnigan T, Blackman MJ, , 1999. Merozoite surface protein 1, immune evasion, and vaccines against asexual blood stage malaria. Parassitologia 41: 409414.
  6. Tanabe K, Escalante A, Sakihama N, Honda M, Arisue N, Horii T, Culleton R, Hayakawa T, Hashimoto T, Longacre S, Pathirana S, Handunnetti S, Kishino H, , 2007. Recent independent evolution of msp1 polymorphism in Plasmodium vivax and related simian malaria parasites. Mol Biochem Parasitol 156: 7479.[Crossref]
  7. Combe A, Giovannini D, Carvalho TG, Spath S, Boisson B, Loussert C, Thiberge S, Lacroix C, Gueirard P, Menard R, , 2009. Clonal conditional mutagenesis in malaria parasites. Cell Host Microbe 5: 386396.[Crossref]
  8. Blackman MJ, Holder AA, , 1992. Secondary processing of the Plasmodium falciparum merozoite surface protein-1 (MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1. Mol Biochem Parasitol 50: 307315.[Crossref]
  9. Malkin E, Dubovsky F, Moree M, , 2006. Progress towards the development of malaria vaccines. Trends Parasitol 22: 292295.[Crossref]
  10. Tanabe K, Mackay M, Goman M, Scaife JG, , 1987. Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum . J Mol Biol 195: 273287.[Crossref]
  11. Tanabe K, Sakihama N, Walliker D, Babiker H, Abdel-Muhsin AM, Bakote'e B, Ohmae H, Arisue N, Horii T, Rooth I, Farnert A, Bjorkman A, Ranford-Cartwright L, , 2007. Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1. Gene 397: 153160.[Crossref]
  12. Sawai H, Otani H, Arisue N, Palacpac N, de Oliveira Martins L, Pathirana S, Handunnetti S, Kawai S, Kishino H, Horii T, Tanabe K, , 2010. Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites. BMC Evol Biol 10: 52.[Crossref]
  13. Putaporntip C, Jongwutiwes S, Sakihama N, Ferreira MU, Kho WG, Kaneko A, Kanbara H, Hattori T, Tanabe K, , 2002. Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus. Proc Natl Acad Sci U S A 99: 1634816353.[Crossref]
  14. Pasay MC, Cheng Q, Rzepczyk C, Saul A, , 1995. Dimorphism of the C terminus of the Plasmodium vivax merozoite surface protein 1. Mol Biochem Parasitol 70: 217219.[Crossref]
  15. del Portillo HA, Longacre S, Khouri E, David PH, , 1991. Primary structure of the merozoite surface antigen 1 of Plasmodium vivax reveals sequences conserved between different Plasmodium species. Proc Natl Acad Sci U S A 88: 40304034.[Crossref]
  16. Bastos MS, da Silva-Nunes M, Malafronte RS, Hoffmann EH, Wunderlich G, Moraes SL, Ferreira MU, , 2007. Antigenic polymorphism and naturally acquired antibodies to Plasmodium vivax merozoite surface protein 1 in rural Amazonians. Clin Vaccine Immunol 14: 12491259.[Crossref]
  17. Choi YK, Choi KM, Park MH, Lee EG, Kim YJ, Lee BC, Cho SH, Rhie HG, Lee HS, Yu JR, Lee JS, Kim TS, Kim JY, , 2010. Rapid dissemination of newly introduced Plasmodium vivax genotypes in South Korea. Am J Trop Med Hyg 82: 426432.[Crossref]
  18. Cui L, Escalante AA, Imwong M, Snounou G, , 2003. The genetic diversity of Plasmodium vivax populations. Trends Parasitol 19: 220226.[Crossref]
  19. Leclerc MC, Menegon M, Cligny A, Noyer JL, Mammadov S, Aliyev N, Gasimov E, Majori G, Severini C, , 2004. Genetic diversity of Plasmodium vivax isolates from Azerbaijan. Malar J 3: 40.[Crossref]
  20. Severini C, Menegon M, Di Luca M, Abdullaev I, Majori G, Razakov SA, Gradoni L, , 2004. Risk of Plasmodium vivax malaria reintroduction in Uzbekistan: genetic characterization of parasites and status of potential malaria vectors in the Surkhandarya region. Trans R Soc Trop Med Hyg 98: 585592.[Crossref]
  21. Zakeri S, Dinparast Djadid N, Zeinali S, , 2003. Sequence heterogeneity of the merozoite surface protein-1 gene (MSP-1) of Plasmodium vivax wild isolates in southeastern Iran. Acta Trop 88: 9197.[Crossref]
  22. Zakeri S, Mehrizi AA, Mamaghani S, Noorizadeh S, Snounou G, Djadid ND, , 2006. Population structure analysis of Plasmodium vivax in areas of Iran with different malaria endemicity. Am J Trop Med Hyg 74: 394400.
  23. Zakeri S, Safi N, Afsharpad M, Butt W, Ghasemi F, Mehrizi AA, Atta H, Zamani G, Djadid ND, , 2010. Genetic structure of Plasmodium vivax isolates from two malaria endemic areas in Afghanistan. Acta Trop 113: 1219.[Crossref]
  24. Zeyrek FY, Babaoglu A, Demirel S, Erdogan DD, Ak M, Korkmaz M, Coban C, , 2008. Analysis of naturally acquired antibody responses to the 19-kD C-terminal region of merozoite surface protein-1 of Plasmodium vivax from individuals in Sanliurfa, Turkey. Am J Trop Med Hyg 78: 729732.
  25. Zeyrek FY, Kurcer MA, Zeyrek D, Simsek Z, , 2006. Parasite density and serum cytokine levels in Plasmodium vivax malaria in Turkey. Parasite Immunol 28: 201207.[Crossref]
  26. Sakihama N, Mitamura T, Kaneko A, Horii T, Tanabe K, , 2001. Long PCR amplification of Plasmodium falciparum DNA extracted from filter paper blots. Exp Parasitol 97: 5054.[Crossref]
  27. Karunaweera ND, Ferreira MU, Munasinghe A, Barnwell JW, Collins WE, King CL, Kawamoto F, Hartl DL, Wirth DF, , 2008. Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax . Gene 410: 105112.[Crossref]
  28. Imwong M, Nair S, Pukrittayakamee S, Sudimack D, Williams JT, Mayxay M, Newton PN, Kim JR, Nandy A, Osorio L, Carlton JM, White NJ, Day NP, Anderson TJ, , 2007. Contrasting genetic structure in Plasmodium vivax populations from Asia and South America. Int J Parasitol 37: 10131022.[Crossref]
  29. Thakur A, Alam MT, Sharma YD, , 2008. Genetic diversity in the C-terminal 42 kDa region of merozoite surface protein-1 of Plasmodium vivax (PvMSP-1(42)) among Indian isolates. Acta Trop 108: 5863.[Crossref]
  30. Zakeri S, Raeisi A, Afsharpad M, Kakar Q, Ghasemi F, Atta H, Zamani G, Memon MS, Salehi M, Djadid ND, , 2010. Molecular characterization of Plasmodium vivax clinical isolates in Pakistan and Iran using pvmsp-1, pvmsp-3alpha and pvcsp genes as molecular markers. Parasitol Int 59: 1521.[Crossref]
  31. Moon SU, Lee HW, Kim JY, Na BK, Cho SH, Lin K, Sohn WM, Kim TS, , 2009. High frequency of genetic diversity of Plasmodium vivax field isolates in Myanmar. Acta Trop 109: 3036.[Crossref]
  32. Palacpac NM, Leung BW, Arisue N, Tanabe K, Sattabongkot J, Tsuboi T, Torii M, Udomsangpetch R, Horii T, , 2006. Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections. Mol Biochem Parasitol 150: 353358.[Crossref]
  33. Zhang SY, Xu LS, Lu HM, Zhang YZ, Gao Q, Li LS, , 2004. Genotype detection of the merozoite surface protein alleles of Plasmodium vivax [in Chinese]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 22: 8689.
  34. Thompson JD, Higgins DG, Gibson TJ, , 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 46734680.[Crossref]
  35. Tamura K, Dudley J, Nei M, Kumar S, , 2007. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 15961599.[Crossref]
  36. Watterson GA, , 1975. On the number of segregating sites in genetical models without recombination. Theor Popul Biol 7: 256276.[Crossref]
  37. Tajima F, , 1989. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123: 585595.
  38. Fu YX, Li WH, , 1993. Statistical tests of neutrality of mutations. Genetics 133: 693709.
  39. Rozas J, Sanchez-DelBarrio JC, Messeguer X, Rozas R, , 2003. DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19: 24962497.[Crossref]
  40. Nei M, Gojobori T, , 1986. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3: 418426.
  41. McDonald JH, Kreitman M, , 1991. Adaptive protein evolution at the Adh locus in Drosophila . Nature 351: 652654.[Crossref]
  42. Nachman MW, Brown WM, Stoneking M, Aquadro CF, , 1996. Nonneutral mitochondrial DNA variation in humans and chimpanzees. Genetics 142: 953963.
  43. Van den Eede P, Erhart A, Van der Auwera G, Van Overmeir C, Thang ND, Hung le X, Anne J, D'Alessandro U, , 2010. High complexity of Plasmodium vivax infections in symptomatic patients from a rural community in central Vietnam detected by microsatellite genotyping. Am J Trop Med Hyg 82: 223227.[Crossref]
  44. Ferreira MU, Karunaweera ND, da Silva-Nunes M, da Silva NS, Wirth DF, Hartl DL, , 2007. Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis 195: 12181226.[Crossref]
  45. Babon JJ, Morgan WD, Kelly G, Eccleston JF, Feeney J, Holder AA, , 2007. Structural studies on Plasmodium vivax merozoite surface protein-1. Mol Biochem Parasitol 153: 3140.[Crossref]
  46. Farnert A, , 2008. Plasmodium falciparum population dynamics: only snapshots in time? Trends Parasitol 24: 340344.[Crossref]
  47. Doolan DL, Dobano C, Baird JK, , 2009. Acquired immunity to malaria. Clin Microbiol Rev 22: 1336.[Crossref]
  48. Cheesman S, Raza A, Carter R, , 2006. Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice. Infect Immun 74: 29963001.[Crossref]
  49. Martinelli A, Hunt P, Fawcett R, Cravo PV, Walliker D, Carter R, , 2005. An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi . Malar J 4: 11.[Crossref]
  50. Pattaradilokrat S, Cheesman SJ, Carter R, , 2007. Linkage group selection: towards identifying genes controlling strain specific protective immunity in malaria. PLoS ONE 2: e857.[Crossref]
  51. Wickramarachchi T, Illeperuma RJ, Perera L, Bandara S, Holm I, Longacre S, Handunnetti SM, Udagama-Randeniya PV, , 2007. Comparison of naturally acquired antibody responses against the C-terminal processing products of Plasmodium vivax merozoite surface protein-1 under low transmission and unstable malaria conditions in Sri Lanka. Int J Parasitol 37: 199208.[Crossref]
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Supplementary Data

Supplementary Figures and Table

  • Received : 22 Jun 2010
  • Accepted : 05 Sep 2010

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