Volume 83, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The 200-kD merozoite surface protein of (PvMSP-1) is one of the leading vaccine candidates against malaria. However, the gene encoding PvMSP-1 () is highly polymorphic and is a major obstacle to effective vaccine development. To further understand polymorphism in , we obtained 30 full-length sequences from southeastern Turkey. Comparative analysis of sequences from Turkey and other areas showed substantially limited polymorphism. Substitutions were found at 280 and 162 amino acid sites in samples from other regions and those from Turkey, respectively. Eight substitutions were unique to Turkey. In one of them, D/E at position 1706 in the C-terminal 19-kD region, the K/E change at 1709 was the only polymorphism previously known. Limited diversity was also observed in microsatellites. Data suggest a recent population bottleneck in Turkey that may have obscured a signature for balancing selection in the C-terminal 42-kD region, which was otherwise detectable in other areas.


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Supplementary Figures and Table

  • Received : 22 Jun 2010
  • Accepted : 05 Sep 2010
  • Published online : 06 Dec 2010

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