1921
Volume 83, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Bacterial meningitis is an important cause of morbidity and mortality in children living in low-resource settings. Pediatric bacterial meningitis cases < 5 years of age were identified through a regional hospital surveillance system for 3 years after introduction of routine immunization with type b (Hib) conjugate vaccine in Senegal in July 2005. Cases from the national pediatric hospital were also tracked from 2002 to 2008. The regional surveillance system recorded 1,711 suspected pediatric bacterial meningitis cases. Of 214 laboratory-confirmed cases, 108 (50%) were caused by , 42 (20%) to Hib, and 13 (6%) to . There was a 98% reduction in the number of hospitalized Hib meningitis cases from Dakar Region in 2008 compared with 2002. The surveillance system provides important information to the Ministry of Health as they consider self-funding Hib vaccine and introducing pneumococcal vaccine.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.10-0346
2010-12-06
2017-09-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/83/6/1330.html?itemId=/content/journals/10.4269/ajtmh.2010.10-0346&mimeType=html&fmt=ahah

References

  1. Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA, Maitland K, English M, Marsh K, Scott JA, , 2005. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med 352: 3947.[Crossref]
  2. Mulholland EK, Adegbola RA, , 2005. Bacterial infections–a major cause of death among children in Africa. N Engl J Med 352: 7577.[Crossref]
  3. World Health Organization, 1999. Bacterial etiology of serious infections in young infants in developing countries: results of a multicenter study. The WHO Young Infants Study Group. Pediatr Infect Dis J 18 (Suppl): S17S22.
  4. World Health Organization, 2009. The pediatric bacterial meningitis surveillance network in WHO's African region, 2001–2008. WER 84: 173184.
  5. Ministere de L'Economie et Des Finances Senegal, 2008. Estimations de la Population du Senegal: 0–5 Ans, 15–49 Ans et 60 Ans et Plus de 2002 a 2009. Dakar, Senegal: Bureau Etat Civil et Projections Démographiques.
  6. World Health Organization, 1996. Generic Protocol for Population-Based Surveillance of Haemophilus influenzae type b. WHO/VRD/GEN/95.05. Geneva: WHO Global Programme for Vaccines and Immunization.
  7. Otten MW, Soriano-Gabarró M, Shaba K, Kay B, Mhlanga B, Wenger J, , 2001. Hib-Paediatric Bacterial Meningitis (Hib-PBM) Surveillance Network: Surveillance Manual, Field Test Version, July 2001. Harare, Zimbabwe: World Health Organization Regional Office for Africa.
  8. Popovic T, Ajello G, Facklam R, , 1999. Laboratory Manual for the Diagnosis of Meningitis Caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. WHO/CDS/CSR/EDC/99.7. Geneva: World Health Organization, Communicable Disease Surveillance and Response.
  9. United Nations Children's Fund, 2008. Product menu for vaccines supplied by UNICEF for the Global Alliance for Vaccines and Immunizations (GAVI). Available at: http://www.unicef.org/supply/files/Product_Menu_23_Sept_2008.pdf. Accessed May 21, 2010.
  10. Breugelmans G, , 2008. Senegal Hib Vaccine Impact Assessment Mission Report. Paris: Agence de Médecine Préventive.
  11. Peltola H, , 2000. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin Microbiol Rev 13: 302317.[Crossref]
  12. Gessner BD, , 2009. Haemophilus influenzae type b vaccine impact in resource-poor settings in Asia and Africa. Expert Rev Vaccines 8: 91102.[Crossref]
  13. Munson RS, Kabeer MH, Lenoir AA, Granoff DM, , 1989. Epidemiology and prospects for prevention of disease due to Haemophilus influenzae in developing countries. Rev Infect Dis 11: S588S597.[Crossref]
  14. Slack MPE, , 2009. Senegal Mission Report. London: Haemophilus Reference Unit, Respiratory and Systemic Infection laboratory, Health Protection Agency Centre for Infections.
  15. Adegbola RA, Secka O, Lahai G, Lloyd-Evans N, Njie A, Usen S, Oluwalana C, Obaro S, Weber M, Corrah T, Mulholland K, McAdam K, Greenwood B, Milligan PJM, , 2005. Elimination of Haemophilus influenzae type b (Hib) disease from The Gambia after the introduction of routine immunisation with a Hib conjugate vaccine: a prospective study. Lancet 366: 144150.[Crossref]
  16. Cowgill KD, Ndiritu M, Nyiro J, Slack MP, Chiphatsi S, Ismail A, Kamau T, Mwangi I, English M, Newton CR, Feikin DR, Scott JA, , 2006. Effectiveness of Haemophilus influenzae type b conjugate vaccine introduction into routine childhood immunization in Kenya. JAMA 296: 671678.[Crossref]
  17. Muganga N, Uwimana J, Fidele N, Gahimbare L, Gessner BD, Mueller JE, Mhlanga BR, Katsande R, Herbinger KH, Rugambwa C, , 2007. Haemophilus influenzae type b conjugate vaccine impact against purulent meningitis in Rwanda. Vaccine 25: 70017005.[Crossref]
  18. Sow SO, Tapia MD, Diallo S, Keita MM, Sylla M, Onwuchekwa U, Pasetti MF, Kotloff KL, Levine MM, , 2009. Haemophilus influenzae Type b conjugate vaccine introduction in Mali: impact on disease burden and serologic correlate of protection. Am J Trop Med Hyg 80: 10331038.
  19. von Gottberg A, de Gouveia L, Madhi SA, du Plessis M, Quan V, Soma K, Huebner R, Flannery B, Schuchat A, Klugman KP, , and the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA), 2006. Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa. Bull World Health Organ 84:811818.[Crossref]
  20. Ribeiro GS, Reis JN, Cordeiro SM, Lima JB, Gouveia EL, Petersen M, Salgado K, Silva HR, Zanella RC, Almeida SC, Brandileone MC, Reis MG, Ko AI, , 2003. Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. J Infect Dis 187: 109116.[Crossref]
  21. Takala AK, Santosham M, Almeido-Hill J, Wolff M, Newcomer W, Reid R, Kayhty H, Esko E, Makela PH, , 1993. Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children. Pediatr Infect Dis J 12: 593599.[Crossref]
  22. Takala AK, Eskola J, Leinonen M, Kayhty H, Nissinen A, Pekkanen E, Makela PH, , 1991. Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with a Hib conjugate vaccine. J Infect Dis 164: 982986.[Crossref]
  23. Adegbola RA, Mulholland EK, Secka O, Jaffar S, Geenwood BM, , 1998. Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H. influenzae type b among Gambian children. J Infect Dis 177:17581761.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.10-0346
Loading
/content/journals/10.4269/ajtmh.2010.10-0346
Loading

Data & Media loading...

  • Received : 18 Jun 2010
  • Accepted : 28 Sep 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error