1921
Volume 83, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We evaluated the influence of mutations and copy number on artemether and lumefantrine sensitivity in 101 laboratory and adapted Thai isolates of . Approximately one-fourth of these isolates exhibited reduced lumefantrine susceptibility. We found that both mutations and amplification of the gene influenced artemether and lumefantrine sensitivity. Using multivariate analysis, 184F or 1042N alleles and a copy number of ≥ 4 were identified as the independent markers for decreased lumefantrine susceptibility. Separate analysis also indicated that parasites from different geographical areas were influenced by different genetic markers.

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2010-11-05
2017-09-19
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  • Received : 15 Jun 2010
  • Accepted : 04 Aug 2010

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