1921
Volume 83, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Melioidosis is a frequently lethal tropical infection caused by the environmental saprophyte . Although transcutaneous inoculation and inhalation are considered the primary routes of infection, suggestive clinical evidence implicates ingestion as a possible alternative route. We show that in BALB/c and C57BL/6 mice, direct gastric inoculation of high doses of causes systemic infection that may be lethal or cause chronic disseminated infection. Mice may shed bacteria in the stool for weeks after infection, and high titers of -specific IgG are detectable. This report of enteric murine melioidosis supports further consideration of this route of infection.

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  • Received : 28 May 2010
  • Accepted : 16 Aug 2010

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