1921
Volume 83, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Microsporidiosis often occurs in immunocompromised persons but may also occur in those who are immunocompetent. Infection by Microsporidia involves a variety of organs and systems, most notably, intestine, lung, kidney, brain, sinuses, muscle, and eyes. and are associated with gastroenteritis, and and are associated with keratoconjunctivitis. We report a case of chronic microsporidiosis in a 28-year-old woman missionary from Mozambique who came to our diagnostic laboratory with nausea, lower abdominal pain, and frequent bowel movements. Over two years, the patient was clinically assessed and treated for malaria and giardiasis without laboratory diagnosis while in Mozambique. Identification of the causative agent of her condition was not attempted during the course of her illness in Mozambique. Furthermore, adverse effects of malaria and giardiasis medications may have exacerbated the chronic illness in this patient and mimicked chronic microsporidiosis.

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2010-11-05
2017-09-24
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References

  1. Lee SC, Corradi N, Byrnes EJ, Torres-Martinez S, Dietrich FS, Keeling PJ, Heitman J, , 2008. Microsporidia evolved from ancestral sexual fungi. Curr Biol 18: 16751679.[Crossref]
  2. Centers for Disease Control and Prevention, 2010. Parasites and Health. Microsporidiosis. Available at: http://www.dpd.cdc.gov/dpdx/html/microsporidiosis.htm. Accessed May 19, 2010.
  3. Flynn PM, Sarah S., Long SS, Pickering LK, Prober CG, , 2008. Microsporidia. , eds. Principles and Practice of Pediatric Infectious Diseases. Third edition. Philadelphia: Churchill Livingston/Elsevier, 1225312254.
  4. Gool T, Dankert L, , 1995. Human microsporidiosis: clinical, diagnostic and therapeutic aspects of an increasing infection. Clin Microbiol Infect 1: 7585.[Crossref]
  5. Maartens G, , 2009. Common parasitic infections in the HIV-infected patient. CME 27: 262264.
  6. Tumwine JK, Kekitiinwa A, Nabukeera N, Akiyoshi DE, Buckholt MA, Tzipori S, , 2002. Enterocytozoon bieneusi among children with diarrhea attending Mulago Hospital in Uganda. Am J Trop Med Hyg 67: 299303.
  7. Slodkowicz-Kowalska A, Graczyk TK, Tamang L, Jedrzejewski S, Nowosad A, Zduniak P, Solarczyk P, Girouard AS, Majewska AC, , 2006. Microsporidian species known to infect humans are present in aquatic birds: implications for transmission via water. Appl Environ Microbiol 72: 45404544.[Crossref]
  8. Didier ES, Stovall ME, Green LC, Brindley PJ, Sestak K, Didier PJ, , 2004. Epidemiology of microsporidiosis: sources and modes of transmission. Vet Parasitol 126: 145166.[Crossref]
  9. Mayor A, Saute F, Aponte JJ, Almeda J, Gomez-Olive FX, Dgedge M, , 2003. Plasmodium falciparum multiple infections in Mozambique, its relation to other malariological indices and to prospective risk of malaria morbidity. Trop Med Int Health 8: 311.[Crossref]
  10. Saute F, Aponte J, Almeda J, Ascaso C, Abellana R, Vaz N, , 2003. Malaria in southern Mozambique: malariometric indicators and malaria case definition in Manhica district. Trans R Soc Trop Med Hyg 97: 661666.[Crossref]
  11. Saute F, Aponte J, Almeda J, Ascaso C, Vaz N, Dgedge M, , 2003. Malaria in southern Mozambique: incidence of clinical malaria in children living in a rural community in Manhica district. Trans R Soc Trop Med Hyg 97: 655660.[Crossref]
  12. Mabunda S, Aponte JJ, Tiago A, Alonso P, , 2009. A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings. Malar J 8: 74.[Crossref]
  13. Faladea C, Makangab M, Premjic Z, Ortmannd CE, Stockmeyerd M, de Palaciosd PI, , 2005. Efficacy and safety of artemether–lumefantrine (Coartem®) tablets (six-dose regimen) in African infants and children with acute, uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 99: 459467.[Crossref]
  14. Gardner TB, Hill DR, , 2001. Treatment of giardiasis. Clin Microbiol Rev 14: 114128.[Crossref]
  15. Stark D, Barratt JL, van Hal S, Marriott D, Harkness J, Ellis JT, , 2009. Clinical significance of enteric protozoa in the immunosuppressed human population. Clin Microbiol Rev 22: 634650.[Crossref]
  16. Weber R, Bryan RT, , 1994. Microsporidial infections in immunodeficient and immunocompetent patients. Clin Infect Dis 19: 517521.[Crossref]
  17. Lanternier F, Boutboul D, Menotti J, Chandesris MO, Sarfati C, Bruneel MF, Calmus Y, Mechai F, Viard JP, Lecuit M, Bougnoux ME, Lortholary O, , 2009. Microsporidiosis in solid organ transplant recipients: two Enterocytozoon bieneusi cases and review. Transpl Infect Dis 11: 8388.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.10-0305
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  • Received : 28 May 2010
  • Accepted : 16 Jul 2010

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