1921
Volume 83, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Critically ill patients with disseminated strongyloidiasis may not be candidates for oral treatment. We report four patients with disseminated strongyloidiasis, believed to be unable to absorb oral therapy, who were treated with ivermectin by rectal and/or subcutaneous administration. Obtaining subcutaneous ivermectin and dosing it appropriately is a challenge. These cases underscore the need for improved access to subcutaneous ivermectin and more pharmacological data to guide use of this treatment approach.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.10-0258
2010-10-05
2017-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/83/4/879.html?itemId=/content/journals/10.4269/ajtmh.2010.10-0258&mimeType=html&fmt=ahah

References

  1. Igual-Adell R, Oltra-Alcaraz C, Soler-Company E, Sánchez-Sánchez P, Matogo-Oyana J, Rodríguez-Calabuig D, , 2004. Efficacy and safety of ivermectin and thiabendazole in the treatment of Strongyloidiasis . Expert Opin Pharmacother 5: 26152619.[Crossref]
  2. Marti H, Haji JH, Savioli L, Chwaya HM, Mgeni AF, Ameir JS, Hatz C, , 1996. A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyoides stercoralis and other soil-transmitted helminth infections in children. Am J Trop Med Hyg 55: 477481.
  3. Igra-Siegman Y, Kapila R, Sen P, Kaminski ZC, Louria DB, , 1981. Syndrome of hyperinfection with Strongyloides stercoralis . Rev Infect Dis 3: 397407.[Crossref]
  4. Cruz T, Reboucas G, Rocha H, , 1966. Fatal Strongyloidiasis in patients receiving corticosteroids. N Engl J Med 275: 10931096.[Crossref]
  5. Chiodini PL, Reid AJ, Wiselka MJ, Firmin R, Fowerake J, , 2000. Parenteral ivermectin in Strongyloides hyperinfection. Lancet 355: 4344.[Crossref]
  6. Turner SA, Maclean D, Fleckenstein L, Greenaway C, , 2005. Parenteral administration of ivermectin in a patient with disseminated Strongyloidiasis . Am J Trop Med Hyg 73: 911914.
  7. Marty FM, Lowry CM, Rodriguez M, Milner D, Pieciak W, Sinha A, Fleckenstein L, Baden LR, , 2005. Treatment of human disseminated Strongyloidiasis with a parenteral veterinary formulation of ivermectin. Clin Infect Dis 41: e5e8.[Crossref]
  8. Hauber HP, Galle J, Chiodini PL, Rupp J, Birke R, Vollmer E, Zabel P, Lange C, , 2005. Fatal Outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin. Infection 33: 383386.[Crossref]
  9. Lichtenberger P, Rosa-Cunha I, Morris M, Nishida S, Akpinar E, Gaitan J, Tzakis A, Doblecki-Lewis S, , 2009. Hyperinfection Strongyloidiasis in a liver transplant recipient treated with parenteral ivermectin. Transpl Infect Dis 11: 137142.[Crossref]
  10. Pacanowski J, Santos MD, Roux A, Maignan C, Guillot J, Lavarde V, Cornet M, , 2005. Subcutaneous ivermectin as safe salvage treatment in Strongyloides stercoralis hyperinfection syndrome: a case report. Am J Trop Med Hyg 73: 122124.
  11. Leung V, Al-Rawahi GN, Frant J, Fleckenstein L, Bowie W, , 2008. Case report: failure of subcutaneous ivermectin in treating Stronygloides hyperinfection. Am J Trop Med Hyg 79: 853855.
  12. Miller MA, Church LW, Salgado CD, , 2008. Strongyloides hyperinfection: a treatment dilemma. Am J Med Sci 336: 358361.[Crossref]
  13. Grein J, Mathisen G, Donovan S, Fleckenstein L, , 2010. Serum ivermectin levels after enteral and subcutaneous administration for Strongyloides hyperinfection: a case report. Scandanavian Journal Infect Dis 42: 234236.[Crossref]
  14. Huston JM, Eachempati SR, Rodney JR, Cayci C, Fusco D, Mathew M, Shou J, Goldstein MJ, Kapur S, Barie PS, , 2009. Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotecogin alfa (activated) in a renal transplant recipient. Transpl Infect Dis 11: 227280.[Crossref]
  15. Tarr PE, Miele PS, Peregoy K, Smith M, Neva F, Lucey D, , 2003. Case report: rectal administration of ivermectin to a patient with Strongyloides hyperinfection syndrome. Am J Trop Med Hyg 68: 453455.
  16. Marcos LA, Terashima A, Dupont HL, Gotuzzo E, , 2008. Strongyloides hyperinfection syndrome: an emerging global infectious disease. Trans R Soc Trop Med Hyg 102: 314318.[Crossref]
  17. Qu Z, Kundu UR, Abadeer RA, Wanger A, , 2009. Strongyloides colitis is a lethal mimic of ulcerative colitis: the key morphologic differential diagnosis. Hum Pathol 40: 572577.[Crossref]
  18. Fardet L, Genereau T, Cabane J, Kettaneh A, , 2006. Severe strongyloidiasis in corticosteroid-treated patients. Clin Microbiol Infect 12: 945947.[Crossref]
  19. Boulware DR, Stauffer WM, Hendel-Paterson BR, Rocha JL, Seet RC, Summer AP, Nield LS, Supparatpinyo K, Chaiwarith R, Walker PF, , 2007. Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey. Am J Med 120: e1e8.[Crossref]
  20. Suputtamongkol Y, Kungpanichkul N, Silpasakorn S, Beeching NJ, , 2008. Efficacy and safety of a single-dose veterinary preparation of ivermectin versus 7 day high-dose albendazole for chronic strongyloidiasis. Int J Antimicrob Agents 31: 4649.[Crossref]
  21. Terashima A, Alvarez H, Tello R, Infante R, Freedman DO, Gotuzzo E, , 2002. Treatment failure in intestinal strongyloidiasis: an indicator of HTLV-I infection. Int J Infect Dis 6: 2830.[Crossref]
  22. Genta RM, , 1992. Dysregulation of strongyloidiasis: a new hypothesis. Clin Microbiol Rev 5: 345355.[Crossref]
  23. March Blatt J, Cantos G, , 2003. Evaluation of techniques for the diagnosis of Strongyloides stercoralis in human immunodeficiency virus (HIV) positive and HIV negative individuals in the city of Itajai, Brazil. Braz J Infect Dis 7: 402408.
  24. Campbell WC, Campbell WC, , 1989. Safety of ivermectin in target animals. , ed. Ivermectin and Abamectin. New York: Springer-Verlag, 157.[Crossref]
  25. Mansfield LS, Schad GA, , 1992. Ivermectin treatment of naturally acquired and experimentally induced Strongyloides stercoralis infections in dogs. J Am Vet Med Assoc 201: 726730.
  26. Stromectol. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050742s022lbl.pdf. Accessed March 8, 2010.
  27. Guzzo CA, Furtek CI, Porras AG, Chen C, Tipping R, Clineschmidt CM, Sciberras DG, Hseih JY, Lasseter KC, , 2002. Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol 42: 11221133.[Crossref]
  28. Satou T, Koga M, Koike K, Taka I, Nikaido T, , 2001. Nematocidal activities of thiabendazole and ivermectin against the larvae of Strongyloides ratti and S. venezuelensis . Vet Parasitol 99: 311322.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.10-0258
Loading
/content/journals/10.4269/ajtmh.2010.10-0258
Loading

Data & Media loading...

  • Received : 05 May 2010
  • Accepted : 02 Jul 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error