1921
Volume 83, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A prospective longitudinal study of in pregnant women was conducted in the rural village of Ngali II, where malaria is hyperendemic and individuals receive ~0.7 infectious mosquito bites/person/day throughout the year. Pregnant women ( = 60; 19 primigravidae, 41 multigravidae) were enrolled early in pregnancy (median 14 wk) and were followed monthly, with 38 women followed through term (5.7 ± 1.1 prenatal visits and delivery). The total number of times primigravidae were slide-positive during pregnancy was higher than multigravidae (3.3 ± 1.1 versus 1.3 ± 1.3 times; < 0.001), but no difference in the number of polymerase chain reaction-positive cases (4.6 ± 1.7 and 3.4 ± 1.7 times, = 0.106) or total genotypes they harbored (8.9 ± 3.2 and 7.0 ± 2.9) was found. Only 7.9% women developed symptomatic infections. All primigravidae and 38% multigravidae were placental malaria-positive at delivery ( = 0.009). Genotyping showed that 77% of placental parasites were acquired ≥ 30 wks in pregnancy. These results help identify the extent of malaria-associated changes women experience during pregnancy.

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References

  1. Brabin BJ, , 1983. An analysis of malaria in pregnancy in Africa. Bull World Health Organ 61: 10051016.
  2. McGregor IA, , 1984. Epidemiology, malaria and pregnancy. Am J Trop Med Hyg 33: 517525.
  3. Steketee RW, Nahlen BL, Parise ME, Menendez C, , 2001. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg 64: 2835.
  4. Mendendez C, , 1995. Malaria during pregnancy: a priority area of malaria research and control. Parasitol Today 11: 178183.[Crossref]
  5. Guyatt HL, Snow RW, , 2001. The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa. Am J Trop Med Hyg 64: 3644.
  6. Desai M, ter Kuile FO, Nosten F, McGready R, Asamoa K, Brabin B, Newman RD, , 2007. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis 7: 93104.[Crossref]
  7. Fried M, Duffy PE, , 1996. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science 272: 15021504.[Crossref]
  8. Duffy PE, Fried M, , 2003. Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Infect Immun 71: 66206623.[Crossref]
  9. Staalsoe T, Shulman CE, Bulmer JN, Kawuondo K, Marsh K, Hviid L, , 2004. Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet 363: 283289.[Crossref]
  10. Gilles HM, Lawson JB, Sibelas M, Voller A, Allan N, , 1969. Malaria, anaemia and pregnancy. Ann Trop Med Parasitol 63: 245260.[Crossref]
  11. Scott JA, , 1993. Identification of single specimens of the Anopheles gambiae complex by the polymerase chain reaction. Am J Trop Med Hyg 49: 520529.
  12. Favia GA, Della T, Bagayoko M, Lanfrncotti A, Sagnon NF, Tour YT, Coluzzi M, , 1997. Molecular identification of sympatric chromosomal forms of Anopheles gambiae and further evidence of their reproductive isolation. Insect Mol Biol 6: 377383.[Crossref]
  13. Wirtz RA, Zavala F, Charoenvit Y, Campbell GH, Burkot TR, Schneider I, Esser K, Beaudoin RL, Andre RG, , 1987. Comparative testing of Plasmodium falciparum sporozoite monoclonal antibodies for ELISA development. Bull World Health Organ 65: 3945.
  14. Basco LK, Ngane VF, Ndounga M, Same-Ekobo A, Youmba JC, Abodo RT, Soula G, , 2006. Molecular epidemiology of malaria in Cameroon. XXI. Baseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change. Am J Trop Med Hyg 75: 388395.
  15. Basco LK, Ringwald P, , 2007. Molecular epidemiology of malaria in Cameroon. XXIV. Trends of in vitro antimalarial drug responses in Yaounde, Cameroon. Am J Trop Med Hyg 76: 2026.
  16. Bulmer JN, Rasheed FN, Francis N, Morrison L, Greenwood BM, , 1993. Placental malaria. I. Pathological classification. Histopathol 22: 211218.[Crossref]
  17. Ismail MR, Ordi J, Menendez C, Ventura PJ, Aponte JJ, Kahigwa E, Hirt R, Cardesa A, Alonso PL, , 2000. Placental pathology in malaria: a histological, immunohistochemical, and quantitative study. Hum Pathol 31: 8593.[Crossref]
  18. Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN, , 1993. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol Biochem Parasitol 58: 283292.[Crossref]
  19. Walker-Abbey A, Djokam RR, Eno A, Leke RF, Titanji VP, Fogako J, Sama G, Thuita LH, Beardslee E, Snounou G, Zhou A, Taylor DW, , 2005. Malaria in pregnant Cameroonian women: the effect of age and gravidity on submicroscopic and mixed-species infections and multiple parasite genotypes. Am J Trop Med Hyg 72: 229235.
  20. Viriyakosol S, Siripoon N, Petcharapirat C, Petcharapirat P, Jarra W, Thaithong S, Brown KN, Snounou G, , 1995. Genotyping of Plasmodium falciparum isolates by the polymerase chain reaction and potential uses in epidemiological studies. Bull World Health Organ 73: 8595.
  21. Mockenhaupt FP, Rong B, Till H, Eggelte TA, Beck S, Gyasi-Sarpong C, Thompson WNA, Bienzle U, , 2000. Submicroscopic Plasmodium falciparum infections in pregnancy in Ghana. Trop Med Int Health 5: 167173.[Crossref]
  22. Mayengue PI, Rieth H, Khattab A, Issifou S, Kremsner PG, Klinkert MQ, Ntoumi F, , 2004. Submicroscopic Plasmodium falciparum infections and multiplicity of infection in matched peripheral, placental and umbilical cord blood samples from Gabonese women. Trop Med Int Health 9: 949958.[Crossref]
  23. Schleiermacher D, Rogier C, Spiegel A, Tall A, Trape JF, Mercereau-Puijalon O, , 2001. Increased multiplicity of Plasmodium falciparum infections and skewed distribution of individual msp1 and msp2 alleles during pregnancy in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Am J Trop Med Hyg 64: 303309.
  24. Beck S, Mockenhaupt FP, Bienzle U, Eggelte TA, Thompson WN, Stark K, , 2001. Multiplicity of Plasmodium falciparum infection in pregnancy. Am J Trop Med Hyg 65: 631636.
  25. Saute F, Menendez C, Mayor A, Aponte J, Gomez-Olive X, Dgedge M, Alonso P, , 2002. Malaria in pregnancy in rural Mozambique: the role of parity, submicroscopic and multiple Plasmodium falciparum infections. Trop Med Int Health 7: 1928.[Crossref]
  26. Qair SH, Shi PY, Goldman IF, Nahlen BL, Tibayrenc M, Lal AA, , 1998. Predicted and observed alleles of Plasmodium falciparum merozoite surface protein-1 (MSP-1), a potential malaria vaccine antigen. Mol Biochem Parasitol 92: 241252.[Crossref]
  27. Ferreira MU, Ribeiro WL, Tonon AP, Kawamoto F, Rich SM, , 2003. Sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-1 (MSP-1) of Plasmodium falciparum . Gene 304: 6575.[Crossref]
  28. Metselaar D, Van Thiel PM, , 1959. Classification of malaria. Trop Geogr Med 11: 157161. Available at: http://www.rollbackmalaria.org/.
  29. Shi YP, Sayed U, Qari SH, Roberts JM, Udhayakumar A, Oloo AJ, Hawley WA, Kaslow DC, Nahlen BL, Lal AA, , 1996. Natural immune response to the C-terminal 19-kilodalton domain of Plasmodium falciparum merozoite surface protein 1. Infect Immun 64: 27162723.
  30. Johnson AH, Leke RG, Mendell NR, Shon D, Suh YJ, Bomba-Nkolo D, Tchinda V, Kouontchou S, Thuita LW, van der Wel AM, Thomas A, Stowers A, Saul A, Zhou A, Taylor DW, Quakyi IA, , 2004. Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein. Infect Immun 72: 27622771.[Crossref]
  31. Polley SD, Mwangi T, Kocken CH, Thomas AW, Dutta S, Lanar DE, Remarrque E, Ross A, Williams TN, Mwambingu G, Lowe B, Conway DJ, Marsh K, , 2004. Human antibodies to recombinant protein constructs of Plasmodium falciparum apical membrane antigen 1 (AMA1) and their associations with protection from malaria. Vaccine 23: 718728.[Crossref]
  32. Zhou A, Megnekou R, Leke R, Fogako J, Metenou S, Trock B, Taylor DW, Leke RF, , 2002. Prevalence of Plasmodium falciparum infection in pregnant Cameroonian women. Am J Trop Med Hyg 67: 566570.
  33. Tako EA, Zhou A, Lohoue J, Leke R, Taylor DW, Leke RF, , 2005. Risk factors for placental malaria and its effect on pregnancy outcome in Yaounde, Cameroon. Am J Trop Med Hyg 72: 236242.
  34. Anchang-Kimbi JK, Achidi EA, Nkegoum B, Sverremark-Ekström E, Troye-Blomberg M, , 2009. Diagnostic comparison of malaria infection in peripheral blood, placental blood and placental biopsies in Cameroonian parturient women. Malar J 8: 126.[Crossref]
  35. Mokuolu OA, Falade CO, Orogade AA, Okafor HU, Adedoyin OT, Oguonu TA, Dada-Adegbola HO, Oguntayo OA, Ernest SK, Hamer DH, Callahan MV, , 2009. Malaria at parturition in Nigeria: current status and delivery outcome. Infect Dis Obstet Gynecol 473971, 7 pages.
  36. Nyaruhucha CN, Msuya JM, Ngowi B, Gimbi DM, , 2006. Maternal weight gain in second and third trimesters and their relationship with birth weights in Morogoro Municipality, Tanzania. Tanzan Health Res Bull 8: 4144.
  37. Möller B, Gebre-Medhin M, Lindmark G, , 1989. Maternal weight, weight gain and birthweight at term in the rural Tanzanian village of Ilula. Br J Obstet Gynaecol 96: 158166.[Crossref]
  38. Jansen AA, Kusin JA, Thiuri B, Lakhani SA, t Mannetje W, , 1984. Machakos project studies no. XXIV. Anthropometric changes during pregnancy in rural African women. Trop Geogr Med 36: 9197.
  39. Villamor E, Msamanga G, Spiegelman D, Peterson KE, Antelman G, Fawzi WW, , 2003. Pattern and predictors of weight gain during pregnancy among HIV-1-infected women from Tanzania. J Acquir Immune Defic Syndr 32: 560569.[Crossref]
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  • Received : 02 May 2010
  • Accepted : 22 Jul 2010

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