Volume 83, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Whether the exceptionally low prevalence of () infection reported among Malays is also present among aborigines (the Orang Asli) living in northeastern Peninsular Malaysia is unknown. We studied asymptomatic Orang Asli from settlements situated 210 km from the city of Kota Bharu. The infection status was confirmed by a validated serology test. Nineteen percent of 480 Orang Asli tested positive for infection. The prevalence was 40.6% in the birth cohort of the 1940s and declined steadily in later cohorts to under 10% among 12–30 year olds. This may be related to the phases of relocation from the jungles into resettlement camps and ultimately into designated villages near rivers. The low prevalence pattern after the 1970s was probably partly a result of improvement in sanitation and hygiene practice in these villages but other unidentified factors may also be operating.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Uyub AM, Raj SM, Visvanathan R, Nazim M, Aiyar S, Anuar AK, , 1994. Helicobacter pylori infection in north-eastern peninsular Malaysia: evidence for an unusually low prevalence. Scand J Gastroenterol 29: 209213.[Crossref] [Google Scholar]
  2. Raj SM, Yap K, Haq JA, Singh S, Hamid A, , 2001. Further evidence for an exceptionally low prevalence of Helicobacter pylori infection among peptic ulcer patients in northeastern peninsular Malaysia. Trans R Soc Trop Med Hyg 95: 2427.[Crossref] [Google Scholar]
  3. Goh KL, Parasakthi N, , 2001. The racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial south-east Asian country. Eur J Gastroenterol Hepatol 13: 177183.[Crossref] [Google Scholar]
  4. Sasidharan S, Uyub AM, , 2009. Prevalence of Helicobacter pylori infection among asymptomatic healthy blood donors in northern peninsular Malaysia. Trans R Soc Trop Med Hyg 103: 395398.[Crossref] [Google Scholar]
  5. Sasidharan S, Uyub AM, Azlan AA, , 2008. Further evidence of ethnic and gender differences for Helicobacter pylori infection among endoscoped patients. Trans R Soc Trop Med Hyg 102: 12261232.[Crossref] [Google Scholar]
  6. Graham DY, Yamaoka Y, Malaty HM, , 2007. Thoughts about populations with unexpected low prevalences of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 101: 849851.[Crossref] [Google Scholar]
  7. Bonne C, Hartz H, Klerks JV, Posthuma JH, Radsma W, Tjokronegoro S, , 1938. Morphology of the stomach and gastric secretion in Malays and Chinese and the different incidence of gastric ulcer and cancer in these races. Am J Cancer 33: 265279. [Google Scholar]
  8. Tokudome S, Soeripto Triningsih FX, Anantha I, Suzuki S, Kuruki K, , 2005. Rare Helicobacter pylori infection as a factor for the very low stomach cancer incidence in Yogyakarta, Indonesia. Cancer Lett 219: 5761.[Crossref] [Google Scholar]
  9. Iskandar C, , 1976. Orang Asli: The Aboriginal Tribes of Peninsular Malaysia. Kuala Lumpur: Oxford University Press, 1011. [Google Scholar]
  10. Geoffrey B, Cynthia C, , 2002. Tribal Communities in the Malay World: Historical, Cultural and Social Perspectives. Singapore: Institute of Southeast Asian Studies, 7205. [Google Scholar]
  11. Laheij RJ, Straatman H, Jansen JB, Verbeek AL, , 1988. Evaluation of commercially available Helicobacter pylori serology kits: a review. J Clin Microbiol 36: 28032809. [Google Scholar]
  12. Raj SM, Lee YY, Choo KE, Noorizan AM, Zulkifli A, Radzi M, Ang SC, , 2008. Further observations in an area with an exceptionally low prevalence of Helicobacter pylori infection. Trans R Soc Trop Med Hyg 102: 11631166.[Crossref] [Google Scholar]
  13. Tay CY, Mitchell H, Dong Q, Goh KL, Dawes IW, Lan R, , 2009. Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population. BMC Microbiol 9: 126.[Crossref] [Google Scholar]
  14. Mohamed R, Hanafiah A, Rose IM, Manaf MR, Abdullah SA, Sagap I, van Belkam A, Yaacob JA, , 2009. Helicobacter pylori cagA gene variants in Malaysians of different ethnicity. Eur J Clin Microbiol Infect Dis 28: 865869.[Crossref] [Google Scholar]
  15. Colin N, , Center for Orang Asli Concerns, 1997. The Orang Asli of Peninsular Malaysia. Available at: http://www.magickriver.net/oa.htm. Accessed November 17, 2009. [Google Scholar]
  16. Nurgalieva ZZ, Malaty HM, Graham DY, Almuchambetova R, Machmudova A, Kapsultanova D, Osato MS, Hollinger FB, Zhangabylov A, , 2002. Helicobacter pylori infection in Kazakhstan: effect of water source and household hygiene. Am J Trop Med Hyg 67: 201206. [Google Scholar]
  17. Ahmed KS, Khan AA, Ahmed I, Tiwari SK, Habeeb A, Ahi JD, Abid Z, Ahmed N, Habibullah CM, , 2007. Impact of household hygiene and water source on the prevalence and transmission of Helicobacter pylori: a south Indian perspective. Singapore Med J 48: 543549. [Google Scholar]
  18. Zhang L, Eslick GD, Xia XH, Wu C, Phung N, Talley NJ, , 2009. Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol Alcohol 45: 16. [Google Scholar]

Data & Media loading...

  • Received : 19 Apr 2010
  • Accepted : 09 Aug 2010
  • Published online : 05 Nov 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error