Volume 83, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Recent reports from animal models and from cross-sectional studies have suggested that host responses to anti- saliva antibodies may be related to delayed-type hypersensitivity to antigen. In a prospective cohort study, we evaluated 1,080 children from two endemic areas for visceral leishmaniasis (VL) by means of Kaplan-Meier analysis. The incidence rate of delayed-type hypersensitivity to antigen, measured at the 24th follow-up month, was higher among those reactive to saliva antibodies at the beginning of the study (0.0217 cases per person-month) than among those previously negative (0.0131 cases per person-month) ( value for the log-rank test = 0.0006). It seems that mounting an anti-saliva immune response helps the development of a cell-mediated anti- response.


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  • Received : 27 Mar 2010
  • Accepted : 14 Jul 2010
  • Published online : 05 Oct 2010

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