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Volume 83, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Cutaneous leishmaniasis caused by infection affected 172 (18.3%) of 938 Dutch military troops deployed in northern Afghanistan in 2005. The high attack rate was a result of initial insufficient availability of means of prevention and insufficient adherence to preventive measures. At presentation, the lymphatic system was involved in 24.8%. Treatment with intralesional injections of antimony with or without cryotherapy was satisfactory, but 19.5% of patients received secondary treatment with miltefosine. Six months after treatment, 128 (77.1%) of 166 treated patients were cured, 16 (9.6%) were lost to follow-up, and 22 (13.3%) already experienced cure at six weeks but were not seen at six months. Natural evolution played a role in this observational study, which showed cure of all patients seen at six months. In general, management of cutaneous leishmaniasis was feasible under field conditions.

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2010-12-06
2017-09-24
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References

  1. Reyburn H, Rowland M, Mohsen M, Khan B, Davies C, , 2003. The prolonged epidemic of anthroponotic cutaneous leishmaniasis in Kabul, Afghanistan: “bringing down the neighbourhood.” Trans R Soc Trop Med Hyg 97: 170176.[Crossref]
  2. Reithinger R, Mohsen M, Aadil K, Sidiqi M, Erasmus P, Coleman PG, , 2003. Anthroponotic cutaneous leishmaniasis, Kabul, Afghanistan. Emerg Infect Dis 9: 727729.[Crossref]
  3. Nadim A, Javadian E, Noushin MK, Nayil AK, , 1979. Epidemiology of cutaneous leishmaniasis in Afghanistan. Part I: zoonotic cutaneous leishmaniasis. Bull Soc Pathol Exot 72: 3135.
  4. Ahmad K, , 2002. War and gerbils compound Afghan leishmaniasis epidemic. Lancet Infect Dis 2: 268.[Crossref]
  5. Faulde M, Schrader J, Heyl G, Amirih M, , 2008. Differences in transmission seasons as an epidemiological tool for characterization of anthroponotic and zoonotic cutaneous leishmaniasis in northern Afghanistan. Acta Trop 105: 131138.[Crossref]
  6. Marfurt J, Nassereddin A, Niederweiser I, Jaffe CL, Beck HP, Felger I, , 2003. Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis. J Clin Microbiol 41: 31473153.[Crossref]
  7. van der Meide WF, Schoone GJ, Faber WR, Zeegelaar JE, de Vries HJ, Özbel Y, Lai A Fat RF, Coelho LI, Kassi M, Schallig HD, , 2005. Quantitative nucleic acid sequence–based assay as a new molecular tool for detection and quantification of Leishmania parasites in skin biopsy samples. J Clin Microbiol 43: 55605566.[Crossref]
  8. van Thiel PP, Leenstra T, Kager PA, de Vries HJ, van Vugt M, van der Meide WF, Bart A, Zeegelaar JE, van der Sluis AJ, Schallig HD, van Gool T, Faber WR, de Vries PJ, , 2010. Miltefosine treatment of Leishmania major infection: an observational study involving Dutch military personnel returning from northern Afghanistan. Clin Infect Dis 50: 8083.[Crossref]
  9. Wong T, Tam W, , 2004. Estimating SARS incubation period. Emerg Infect Dis 10: 15031504.[Crossref]
  10. Tam WW, Wong T, , 2007. Estimating incubation period with multiple contact days. Scand J Infect Dis 39: 607611.
  11. Faulde M, Schrader J, Heyl G, Amirih M, Hoerauf A, , 2008. Zoonotic cutaneous leishmaniasis outbreak in Mazar-e-Sharif, northern Afghanistan: an epidemiological evaluation. Int J Med Microbiol 298: 543550.[Crossref]
  12. Kubba R, El-Hassan AM, Al-Gindan Y, Omer AH, Kutty MK, Saeed MB, , 1987. Dissemination in cutaneous leishmaniasis. I. Subcutaneous nodules. Int J Dermatol 26: 300304.[Crossref]
  13. Kubba R, Al-Gindan Y, El-Hassan AM, Omer AH, Kutty MK, Saeed MB, , 1988. Dissemination in cutaneous leishmaniasis. II. Sattelite papules and subcutaneous induration. Int J Dermatol 27: 702706.[Crossref]
  14. Al-Gindan Y, Kubba R, El-Hassan AM, Omer AH, Kutty MK, Saeed MB, , 1989. Dissemination in cutaneous leishmaniasis. 3. Lymph node involvement. Int J Dermatol 28: 248254.[Crossref]
  15. Dowlati Y, , 1996. Cutaneous leishmaniasis: clinical aspects. Clin Dermatol 14: 425431.[Crossref]
  16. Elfari M, Schnur LF, Strelkova MV, Eisenberger CL, Jacobson RL, Greenblatt CL, Presber W, Schönian G, , 2005. Generic and biological diversity among populations of Leishmania major from Central Asia, the Middle East and Africa. Microbes Infect 7: 93103.[Crossref]
  17. Gaafar A, Fadl A, El Kadaro AY, El Hassan MM, Kemp M, Ismael AI, Morgos SA, El Hassan AM, , 1994. Sporothrichoid cutaneous leishmaniasis due to Leishmania major of different zymodemes in the Sudan and Saudi Arabia: a comparative study. Trans R Soc Trop Med Hyg 88: 552554.[Crossref]
  18. Faulde MK, Heyl G, Amirih ML, , 2006. Zoonotic cutaneous leishmaniasis, Afghanistan. Emerg Infect Dis 10: 16231624.[Crossref]
  19. Gonzalez U, Pinart M, Reveiz L, Alvar J, , 2008. Interventions for Old World cutaneous leishmaniasis. Cochrane Database Syst Rev CD005067. doi:10.1002/14651858.CD005067.pub3
  20. Kubba R, Al-Gindan Y, , 1989. Leishmaniasis. Dermatol Clin 89: 149159.
  21. Gaafar A, Ismail A, El Kadaro AY, Hashim E, Khalil EA, El Hassan AM, , 1996. Necrotizing and suppurative lymphadenitis in Leishmania major infections. Trop Med Int Health 1: 243249.[Crossref]
  22. Al-Gindan Y, Kubba R, Omer AH, El-Hassan AM, , 1988. Cryosurgery in old world cutaneous leishmaniasis. Br J Dermatol 118: 851854.[Crossref]
  23. Uzun S, Uslular A, Yücel A, Acar MA, Özpoyraz M, Memişsoğglu HR, , 1999. Cutaneous leishmaniasis: evaluation of 3074 cases in the Cukurova region of Turkey. Br J Dermatol 140: 347350.[Crossref]
  24. Uzun S, Durdu M, Culha G, Allahverdiyec AM, Memisoglu HR, , 2004. Clinical features, epidemiology and efficacy and safety of intralesional antimony treatment of cutaneous leishmaniasis: recent experience in Turkey. J Parasitol 90: 853859.[Crossref]
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  • Received : 04 Mar 2010
  • Accepted : 14 Jul 2010

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