Volume 83, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Guaroa virus (GROV) was first isolated from humans in Colombia in 1959. Subsequent isolates of the virus have been recovered from febrile patients and mosquitoes in Brazil, Colombia, and Panama; however, association of the virus with human disease has been unclear. As part of a study on the etiology of febrile illnesses in Peru and Bolivia, 14 GROV strains were isolated from patients with febrile illnesses, and 3 additional cases were confirmed by IgM seroconversion. The prevalence rate of GROV antibodies among Iquitos residents was 13%; the highest rates were among persons with occupations such as woodcutters, fisherman, and oil-field workers. Genetic characterization of representative GROV isolates indicated that strains from Peru and Bolivia form a monophyletic group that can be distinguished from strains isolated earlier in Brazil and Colombia. This study confirms GROV as a cause of febrile illness in tropical regions of Central and South America.


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  1. Groot H, Oya A, Bernal C, Barreto-Reyes P, , 1959. Guaroa virus, a new agent isolated in Colombia, South America. Am J Trop Med Hyg 8: 604609. [Google Scholar]
  2. Causey OR, Shope RE, Rodrigues Filho A, , 1962. Isolamento do virus Guaroa do figado por biopsia percutanea de um caso humano com paralisia. Rev Serv Espec Saude Pub 12: 5559. [Google Scholar]
  3. Causey OR, Causey CE, Maroja OM, Macedo DG, , 1961. The isolation of arthropod-borne viruses, including members of two hitherto undescribed serologic groups, in the Amazon region of Brazil. Am J Trop Med Hyg 10: 227249. [Google Scholar]
  4. Lee VH, Sanmartin C, , 1967. Isolations of Guaroa virus from Anopheles (Kerteszia) Neivai in the Pacific lowlands of Colombia. Am J Trop Med Hyg 16: 778781. [Google Scholar]
  5. Groot H, , 1964. Estudios sobre virus transmitidos por artropodos en Colombia. Rev Acad Colomb 12: 197217. [Google Scholar]
  6. Peralta PH, Shelokov A, , 1966. Isolation and characterization of arboviruses from Almirante, Republic of Panama. Am J Trop Med Hyg 15: 369378. [Google Scholar]
  7. Sun X, Fu S, Gong Z, Ge J, Meng W, Feng Y, Wang J, Zhai Y, Wang H, Nasci R, Tang Q, Liang G, , 2009. Distribution of arboviruses and mosquitoes in northwestern Yunnan Province, China. Vector Borne Zoonotic Dis 9: 623630.[Crossref] [Google Scholar]
  8. Vieira Cde M, Nunes MR, da Silva EV, Carvalho VL, Nunes Neto JP, Cruz AC, Casseb SM, Vasconcelos HB, Quaresma JA, Vasconcelos PF, , 2009. Full-length sequencing and genetic characterization of Breu Branco virus (Reoviridae, Orbivirus) and two related strains isolated from Anopheles mosquitoes. J Gen Virol 90: 21832190.[Crossref] [Google Scholar]
  9. Theiler M, Downs WG, , 1973. The Arthropod-Borne Viruses of Vertebrates. New Haven, CT: Yale University Press. [Google Scholar]
  10. Nichol ST, Beaty BJ, Elliott RM, Goldbach R, Plyusnin A, Schmaljohn CS, Tesh RB, Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, , 2005. Family Bunyaviridae. , eds. Virus Taxonomy. Eighth Report of the International Committee on Taxonomy of Viruses. San Diego, CA: Elsevier Academic Press, 695716. [Google Scholar]
  11. Gentsch JR, Bishop DH, , 1978. Small viral RNA segment of bunyaviruses codes for viral nucleocapsid protein. J Virol 28: 417419. [Google Scholar]
  12. Gentsch JR, Bishop DHL, , 1979. M viral RNA segment of bunyaviruses codes for two glycoproteins, G1 and G2. J Virol 30: 767770. [Google Scholar]
  13. Calisher CH, Elliot RM, , 1996. History, classification and taxonomy of viruses in the family Bunyaviridae. , ed. The Bunyaviridae. New York: Plenum Press, 117.[Crossref] [Google Scholar]
  14. Whitman L, Shope RE, , 1962. The California complex of arthropod-borne viruses and its relationship to the Bunyamwera group through Guaroa virus. Am J Trop Med Hyg 11: 691696. [Google Scholar]
  15. Bishop DH, Pinheiro FP, , 1982. The molecular properties of bunyaviruses including Group C isolates and the genetic capabilities of bunyaviruses to form recombinants. , ed. International Symposium on Tropical Arboviruses and Haemorrhagic Fevers. Rio de Janeiro, Brazil: Academia Brasileira de Ciencias, 117133. [Google Scholar]
  16. Dunn EF, Pritlove DC, Elliott RM, , 1994. The S RNA genome segments of Batai, Cache Valley, Guaroa, Kairi, Lumbo, Main Drain and Northway bunyaviruses: sequence determination and analysis. J Gen Virol 75: 597608.[Crossref] [Google Scholar]
  17. Watts DM, Callahan J, Rossi C, Oberste MS, Roehrig JT, Wooster MT, Smith JF, Cropp CB, Gentrau EM, Karabatsos N, Gubler D, Hayes CG, , 1998. Venezuelan equine encephalitis febrile cases among humans in the Peruvian Amazon River region. Am J Trop Med Hyg 58: 3540. [Google Scholar]
  18. Morrison AC, Forshey BM, Notyce D, Astete H, Lopez V, Rocha C, Carrion R, Carey C, Eza D, Montgomery JM, Kochel TJ, , 2008. Venezuelan equine encephalitis virus in Iquitos, Peru: urban transmission of a sylvatic strain. PLoS Negl Trop Dis 2: e349.[Crossref] [Google Scholar]
  19. Aguilar PV, Greene IP, Coffey LL, Medina G, Moncayo AC, Anishchenko M, Ludwig GV, Turell MJ, O'Guinn ML, Lee J, Tesh RB, Watts DM, Russell KL, Hice C, Yanoviak S, Morrison AC, Klein TA, Dohm DJ, Guzman H, Travassos da Rosa AP, Guevara C, Kochel T, Olson J, Cabezas C, Weaver SC, , 2004. Endemic Venezuelan equine encephalitis in northern Peru. Emerg Infect Dis 10: 880888.[Crossref] [Google Scholar]
  20. Oberste MS, Weaver SC, Watts DM, Smith JF, , 1998. Identification and genetic analysis of Panama-genotype Venezuelan equine encephalitis virus subtype ID in Peru. Am J Trop Med Hyg 58: 4146. [Google Scholar]
  21. Watts DM, Lavera V, Callahan J, Rossi C, Oberste MS, Roehrig JT, Cropp CB, Karabatsos N, Smith JF, Gubler DJ, Wooster MT, Nelson WM, Hayes CG, , 1997. Venezuelan equine encephalitis and Oropouche virus infections among Peruvian army troops in the Amazon region of Peru. Am J Trop Med Hyg 56: 661667. [Google Scholar]
  22. Travassos da Rosa AP, Turell MJ, Watts DM, Powers AM, Vasconcelos PF, Jones JW, Klein TA, Dohm DJ, Shope RE, Degallier N, Popov VL, Russell KL, Weaver SC, Guzman H, Calampa C, Brault AC, Lemon AP, Tesh RB, , 2001. Trocara virus: a newly recognized Alphavirus (Togaviridae) isolated from mosquitoes in the Amazon Basin. Am J Trop Med Hyg 64: 9397. [Google Scholar]
  23. Turell MJ, O'Guinn ML, Jones JW, Sardelis MR, Dohm DJ, Watts DM, Fernandez R, Travassos da Rosa A, Guzman H, Tesh R, Rossi CA, Ludwig V, Mangiafico JA, Kondig J, Wasieloski LP, Jr Pecor J, Zyzak M, Schoeler G, Mores CN, Calampa C, Lee JS, Klein TA, , 2005. Isolation of viruses from mosquitoes (Diptera: Culicidae) collected in the Amazon Basin region of Peru. J Med Entomol 42: 891898.[Crossref] [Google Scholar]
  24. Bowen MD, Trappier SG, Sanchez AJ, Meyer RF, Goldsmith CS, Zaki SR, Dunster LM, Peters CJ, Ksiazek TG, Nichol ST, , 2001. A reassortant bunyavirus isolated from acute hemorrhagic fever cases in Kenya and Somalia. Virology 291: 185190.[Crossref] [Google Scholar]
  25. Swofford DL, , 1998. PAUP* Phylogenetic Analysis Using Parsimony (*and Other Methods). Sunderland, MA: Sinauer Associates. [Google Scholar]
  26. Wilgenbusch JC, Swofford D, , 2003. Inferring evolutionary trees with PAUP*. Current Protocols in Bioinformatics, Chapter 6: Unit 6.4. Somerset, NJ: John Wiley & Sons, Inc. [Google Scholar]
  27. Aguilar PV, Robich RM, Turell MJ, O'Guinn ML, Klein TA, Huaman A, Guevara C, Rios Z, Tesh RB, Watts DM, Olson J, Weaver SC, , 2007. Endemic eastern equine encephalitis in the Amazon region of Peru. Am J Trop Med Hyg 76: 293298. [Google Scholar]
  28. Kondig JP, Turell MJ, Lee JS, O'Guinn ML, Wasieloski LP, Jr, 2007. Genetic analysis of South American eastern equine encephalomyelitis viruses isolated from mosquitoes collected in the Amazon Basin region of Peru. Am J Trop Med Hyg 76: 408416. [Google Scholar]
  29. Madalengoitia J, Flores W, Casals J, , 1973. Arbovirus antibody survey of sera from residents of eastern Peru. PAHO Bull 7: 2534. [Google Scholar]
  30. Yanoviak SP, Aguilar PV, Lounibos LP, Weaver SC, , 2005. Transmission of a Venezuelan equine encephalitis complex Alphavirus by Culex (Melanoconion) gnomatos (Diptera: Culicidae) in northeastern Peru. J Med Entomol 42: 404408. [Google Scholar]
  31. Pinheiro FP, Travassos da Rosa APA, Beran GW, , 1994. Guaroa and other Bunyamwera group fevers. , ed. Handbook of Zoonoses. Boca Raton, FL: CRC Press, 217218. [Google Scholar]
  32. Pinheiro FP, Travassos da Rosa APA, Freitas RB, Travassos da Rosa JFS, Vasconcelos PF, , 1986. Aspectos clinico-epidemiologicos dos arbovirus. Instituto Evandro Chagas: 50 anos de contribuicao as ciencias biologicas e a medicina tropical. Belem, Brazil: Fundacao Servicos de Saude Publica, 375408. [Google Scholar]
  33. Beaty BJ, Calisher CH, Shope RE, Schmidt NJ, Emmons EW, , 1989. Arboviruses. , eds. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Washington, DC: American Public Health Association, 797855. [Google Scholar]
  34. Vasconcelos PF, Travassos da Rosa AP, Rodrigues SG, Travassos da Rosa ES, Degallier N, Travassos da Rosa JF, , 2001. Inadequate management of natural ecosystem in the Brazilian Amazon region results in the emergence and reemergence of arboviruses. Cad Saude Publica 17 (Suppl): 155164.[Crossref] [Google Scholar]

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  • Received : 22 Feb 2010
  • Accepted : 11 May 2010
  • Published online : 07 Sep 2010

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