Volume 83, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Neurognathostomiasis is a rare but severe form of human gnathostomiasis. Diagnosis of neurognathostomiasis is made presumably by using clinical manifestations. Serologic tests for neurognathostomiasis are not widely available and limited. We studied 12 patients with diagnoses of neurognathostomiasis at Srinagarind Hospital, Khon Kaen University, Thailand. There were three types of neurognathostomiasis (five patients with intracerebral hemorrhage, one patient with subarachnoid hemorrhage, and six patients with myelitis). All patients were tested for antibodies against by an immunoblotting technique. The sensitivity and specificity of the 21-kD and 24-kD diagnostic bands were 83.3% and 100%, and 91.7% and 100%, respectively. The sensitivity, specificity, positive predictive value, and negative predictive value for the 21-kD and 24-kD diagnostic bands were all 100%. Both diagnostic bands are a helpful diagnostic tool for neuro gnathostomiasis and show good diagnostic properties.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Nawa Y, , 1991. Historical review and current status of gnathostomiasis in Asia. Southeast Asian J Trop Med Public Health 22: 217219. [Google Scholar]
  2. Ogata K, Nawa Y, Akahane H, Diaz Camacho SP, Lamothe-Argumedo R, Cruz-Reyes A, , 1998. Gnathostomiasis in Mexico. Am J Trop Med Hyg 58: 316318. [Google Scholar]
  3. Kraivichian K, Nuchprayoon S, Sitichalernchai P, Chaicumpa W, Yentakam S, , 2004. Treatment of cutaneous gnathostomiasis with ivermectin. Am J Trop Med Hyg 71: 623628. [Google Scholar]
  4. Brant-Zawadzki M, Wofsy CB, Schechter G, , 1982. CT-evidence of subarachnoid hemorrhage due to presumed gnathostomiasis. West J Med 137: 6567. [Google Scholar]
  5. Sawanyawisuth K, Chlebicki MP, Pratt E, Kanpittaya J, Intapan PM, , 2009. Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication. Trans R Soc Trop Med Hyg 103: 102104.[Crossref] [Google Scholar]
  6. Sithinamsuwan P, Chairangsaris P, , 2005. Images in clinical medicine. Gnathostomiasis—neuroimaging of larval migration. N Engl J Med 353: 188.[Crossref] [Google Scholar]
  7. Sawanyawisuth K, Tiamkao S, Nitinavakarn B, Dekumyoy P, Jitpimolmard S, , 2005. MR imaging findings in cauda equina gnathostomiasis. AJNR Am J Neuroradiol 26: 3942. [Google Scholar]
  8. Sawanyawisuth K, Tiamkao S, Kanpittaya J, Dekumyoy P, Jitpimolmard S, , 2004. MR imaging findings in cerebrospinal gnathostomiasis. AJNR Am J Neuroradiol 25: 446449. [Google Scholar]
  9. Boongird P, Phuapradit P, Siridej N, Chirachariyavej T, Chuahirun S, Vejjajiva A, , 1977. Neurological manifestations of gnathostomiasis. J Neurol Sci 31: 279291.[Crossref] [Google Scholar]
  10. Rusnak JM, Lucey DR, , 1993. Clinical gnathostomiasis: case report and review of the English language literature. Clin Infect Dis 16: 3350.[Crossref] [Google Scholar]
  11. Anantaphruti MT, Nuamtanong S, Dekumyoy P, , 2005. Diagnostic values of IgG4 in human gnathostomiasis. Trop Med Int Health 10: 10131021.[Crossref] [Google Scholar]
  12. Laummaunwai P, Sawanyawisuth K, Intapan PM, Chotmongkol V, Wongkham C, Maleewong W, , 2007. Evaluation of human IgG class and subclass antibodies to a 24 kDa antigenic component of Gnathostoma spinigerum for the serodiagnosis of gnathostomiasis. Parasitol Res 101: 703708.[Crossref] [Google Scholar]
  13. Tapchaisri P, Nopparatana C, Chaicumpa W, Setasuban P, , 1991. Specific antigen of Gnathostoma spinigerum for immunodiagnosis of human gnathostomiasis. Int J Parasitol 21: 315319.[Crossref] [Google Scholar]

Data & Media loading...

  • Received : 21 Feb 2010
  • Accepted : 10 Jun 2010
  • Published online : 05 Oct 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error