Volume 83, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Immune reconstitution inflammatory syndrome (IRIS) has become a frequent and potentially severe complication after initiation of following antiretroviral therapy (ART) in patients infected with human immunodeficiency virus (HIV). IRIS can unmask a previously clinically silent infection, such as tuberculosis, as recently described for infections. We describe a case in a patient from Côte d'Ivoire living in France in whom skin papular lesions developed after initiation of ART. These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy.


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  1. DeSimone JA, Pomerantz RJ, Babinchak TJ, 2000. Inflammatory reactions in HIV-1-infected persons after initiation of highly active antiretroviral therapy. Ann Intern Med 133: 447454.[Crossref]
    [Google Scholar]
  2. Ustianowski AP, Lawn SD, Lockwood DN, 2006. Interactions between HIV infection and leprosy: a paradox. Lancet Infect Dis 6: 350360.[Crossref]
    [Google Scholar]
  3. Batista MD, Porro AM, Maeda SM, Gomes EE, Yoshioka MC, Enokihara MM, Tomimori J, 2008. Leprosy reversal reaction as immune reconstitution inflammatory syndrome in patients with AIDS. Clin Infect Dis 46: e56e60.[Crossref]
    [Google Scholar]
  4. Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R, 2008. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 8: 516523.[Crossref]
    [Google Scholar]
  5. Bourgarit A, Carcelain G, Samri A, Parizot C, Lafaurie M, Abgrall S, Delcey V, Vicaut E, Sereni D, Autran B, 2009. Tuberculosis-associated immune restoration syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells. J Immunol 183: 39153923.[Crossref]
    [Google Scholar]
  6. Shelburne SA, Visnegarwala F, Darcourt J, Graviss EA, Giordano TP, White AC Jr, Hamill RJ, 2005. Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS 19: 399406.[Crossref]
    [Google Scholar]
  7. Couppie P, Domergue V, Clyti E, El Guedj M, Vaz T, Sainte-Marie D, Marty C, Nacher M, 2009. Increased incidence of leprosy following HAART initiation: a manifestation of the immune reconstitution disease. AIDS 23: 15991600.[Crossref]
    [Google Scholar]
  8. Lortholary O, Fontanet A, Memain N, Martin A, Sitbon K, Dromer F, 2005. Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France. AIDS 19: 10431049.[Crossref]
    [Google Scholar]
  9. Breton G, Adle-Biassette H, Therby A, Ramanoelina J, Choudat L, Bissuel F, Huerre M, Dromer F, Dupont B, Lortholary O, 2006. Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis. AIDS 20: 119121.[Crossref]
    [Google Scholar]

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  • Received : 01 Feb 2010
  • Accepted : 06 Mar 2010
  • Published online : 06 Jul 2010

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