1921
Volume 83, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Severe rhabdomyolysis (creatine phosphokinase = 29,400U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with . Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with infection showed no comorbidities. The pathogenesis is still unclear.

Although rhabdomyolysis is generally reported as a complication of malaria, leading to metabolic and renal complications, it has been reported in a patient with infection with myoadenylate deaminase deficiency. We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed infection.

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References

  1. Davis TM, Pongponratan E, Supanaranond W, Pukrittayakamee S, Helliwell T, Holloway P, White NJ, 1999. Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. Clin Infect Dis 29: 831835.[Crossref]
    [Google Scholar]
  2. Poels PJ, Dolmans WM, Gabreels FJ, 1993. Rhabdomyolysis associated with malaria tertiana in a patient with myoadenylate deaminase deficiency. Trop Geogr Med 45: 8386.
    [Google Scholar]
  3. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, Rosario VE, Thaithong S, Brown KN, 1993. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 61: 315320.[Crossref]
    [Google Scholar]
  4. Silva HJ, Goonetilleke AK, Senaratna N, Ramesh N, Jayawickrama US, Jayasinghe KS, Amarasekera LR, 1988. Skeletal muscle necrosis in severe falciparum malaria. Br Med J (Clin Res Ed) 296: 1039.[Crossref]
    [Google Scholar]
  5. Swash M, Schwartz MS, 1993. Malaria myositis. J Neurol Neurosurg Psychiatry 56: 1328.[Crossref]
    [Google Scholar]
  6. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, Kochar A, Khatri MP, Gupta V, 2009. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 80: 194198.
    [Google Scholar]
  7. Casado E, Gratacos J, Tolosa C, Martinez JM, Ojanguren I, Ariza A, Real J, Sanjuan A, Larrosa M, 2006. Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients. Ann Rheum Dis 65: 385390.[Crossref]
    [Google Scholar]
  8. Anstey NM, Russell B, Yeo TW, Price RN, 2009. The pathophysiology of vivax malaria. Trends Parasitol 25: 220227.[Crossref]
    [Google Scholar]
  9. Davis TM, Supanaranond W, Pukrittayakamee S, Holloway P, Chubb P, White NJ, 2000. Progression of skeletal muscle damage during treatment of severe falciparum malaria. Acta Trop 76: 271276.[Crossref]
    [Google Scholar]
  10. Knobloch K, Rossner D, Gossling T, Lichtenberg A, Richter M, Krettek C, 2005. Rhabdomyolysis after administration of diclofenac. Unfallchirurg 108: 415417.[Crossref]
    [Google Scholar]
  11. Delrio FG, Park Y, Herzlich B, Grob D, 1996. Case report: diclofenac-induced rhabdomyolysis. Am J Med Sci 312: 9597.
    [Google Scholar]
  12. Brazilian Ministry of Health, 2008. Epidemiology of Malaria in Brazil, 2007. Brasília: Ministério da Saúde.
    [Google Scholar]
  13. Lacerda MV, Alexandre MA, Santos PD, Arcanjo AR, Alecrim WD, Alecrim MG, 2004. Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon. Acta Trop 90: 187190.[Crossref]
    [Google Scholar]
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  • Received : 14 Jan 2010
  • Accepted : 16 Apr 2010
  • Published online : 05 Aug 2010
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