1921
Volume 83, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Severe rhabdomyolysis (creatine phosphokinase = 29,400U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with . Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with infection showed no comorbidities. The pathogenesis is still unclear.

Although rhabdomyolysis is generally reported as a complication of malaria, leading to metabolic and renal complications, it has been reported in a patient with infection with myoadenylate deaminase deficiency. We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed infection.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.10-0027
2010-08-05
2017-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/83/2/271.html?itemId=/content/journals/10.4269/ajtmh.2010.10-0027&mimeType=html&fmt=ahah

References

  1. Davis TM, Pongponratan E, Supanaranond W, Pukrittayakamee S, Helliwell T, Holloway P, White NJ, , 1999. Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. Clin Infect Dis 29: 831835.[Crossref]
  2. Poels PJ, Dolmans WM, Gabreels FJ, , 1993. Rhabdomyolysis associated with malaria tertiana in a patient with myoadenylate deaminase deficiency. Trop Geogr Med 45: 8386.
  3. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, Rosario VE, Thaithong S, Brown KN, , 1993. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 61: 315320.[Crossref]
  4. Silva HJ, Goonetilleke AK, Senaratna N, Ramesh N, Jayawickrama US, Jayasinghe KS, Amarasekera LR, , 1988. Skeletal muscle necrosis in severe falciparum malaria. Br Med J (Clin Res Ed) 296: 1039.[Crossref]
  5. Swash M, Schwartz MS, , 1993. Malaria myositis. J Neurol Neurosurg Psychiatry 56: 1328.[Crossref]
  6. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, Kochar A, Khatri MP, Gupta V, , 2009. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 80: 194198.
  7. Casado E, Gratacos J, Tolosa C, Martinez JM, Ojanguren I, Ariza A, Real J, Sanjuan A, Larrosa M, , 2006. Antimalarial myopathy: an underdiagnosed complication? Prospective longitudinal study of 119 patients. Ann Rheum Dis 65: 385390.[Crossref]
  8. Anstey NM, Russell B, Yeo TW, Price RN, , 2009. The pathophysiology of vivax malaria. Trends Parasitol 25: 220227.[Crossref]
  9. Davis TM, Supanaranond W, Pukrittayakamee S, Holloway P, Chubb P, White NJ, , 2000. Progression of skeletal muscle damage during treatment of severe falciparum malaria. Acta Trop 76: 271276.[Crossref]
  10. Knobloch K, Rossner D, Gossling T, Lichtenberg A, Richter M, Krettek C, , 2005. Rhabdomyolysis after administration of diclofenac. Unfallchirurg 108: 415417.[Crossref]
  11. Delrio FG, Park Y, Herzlich B, Grob D, , 1996. Case report: diclofenac-induced rhabdomyolysis. Am J Med Sci 312: 9597.
  12. Brazilian Ministry of Health, 2008. Epidemiology of Malaria in Brazil, 2007. Brasília: Ministério da Saúde.
  13. Lacerda MV, Alexandre MA, Santos PD, Arcanjo AR, Alecrim WD, Alecrim MG, , 2004. Idiopathic thrombocytopenic purpura due to vivax malaria in the Brazilian Amazon. Acta Trop 90: 187190.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.10-0027
Loading
/content/journals/10.4269/ajtmh.2010.10-0027
Loading

Data & Media loading...

  • Received : 14 Jan 2010
  • Accepted : 16 Apr 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error