Volume 83, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Severe rhabdomyolysis (creatine phosphokinase = 29,400U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with . Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with infection showed no comorbidities. The pathogenesis is still unclear.

Although rhabdomyolysis is generally reported as a complication of malaria, leading to metabolic and renal complications, it has been reported in a patient with infection with myoadenylate deaminase deficiency. We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed infection.


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  • Received : 14 Jan 2010
  • Accepted : 16 Apr 2010

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