1921
Volume 83, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Diarrhea is a major public health problem that affects the development of children. Anthropometric data were collected from 274 children with ( = 170) and without ( = 104) diarrhea. Stool specimens were analyzed by conventional culture, polymerase chain reaction for enteroaggregative (EAEC), , , , and species, and by enzyme-linked immunosorbent assay for fecal lactoferrin levels. About 50% of the study population was mildly to severely malnourished. Fecal lactoferrin levels were higher in children with diarrhea ( = 0.019). Children who had EAEC infection, with or without diarrhea, had high mean lactoferrin levels regardless of nutritional status. The EAEC and were associated with diarrhea ( = 0.048 and 0.011, respectively), and malnourished children who had diarrhea were often co-infected with both and EAEC. In conclusion, the use of DNA-biomarkers revealed that EAEC and were common intestinal pathogens in Accra, and that elevated lactoferrin was associated with diarrhea in this group of children.

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  • Received : 28 Dec 2009
  • Accepted : 06 Jul 2010
  • Published online : 05 Oct 2010

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